An InDel in Phospholipase-C-B-1 Is Linked with Euthyroid Multinodular Goiter

Background: Euthyroid multinodular goiter (MNG) is common, but little is known about the genetic variations conferring predisposition. Previously, a family with MNG of adolescent onset was reported in which some family members developed papillary thyroid carcinomas (PTC). Methods: Genome-wide linkag...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2018-07, Vol.28 (7), p.891-901
Hauptverfasser:	Bakhsh, Ameen D., Ladas, Ioannis, Hamshere, Marian L., Bullock, Martyn, Kirov, George, Zhang, Lei, Taylor, Peter N., Gregory, John W., Scott-Coombes, David, Völzke, Henry, Teumer, Alexander, Mantripragada, Kiran, Williams, E. Dillwyn, Clifton-Bligh, Roderick J., Williams, Nigel M., Ludgate, Marian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult DNA Copy Number Variations Female Genetic Linkage Genetic Predisposition to Disease Goiter, Nodular - genetics Goiter, Nodular - pathology Haplotypes Humans Introns - genetics Male Middle Aged Pedigree Phospholipase C beta - genetics Thyroid Cancer and Nodules Thyroid Gland - pathology Thyroidectomy
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