The Concerted Action of Type 2 and Type 3 Deiodinases Regulates the Cell Cycle and Survival of Basal Cell Carcinoma Cells

Background: Thyroid hormones (THs) mediate pleiotropic cellular processes involved in metabolism, cellular proliferation, and differentiation. The intracellular hormonal environment can be tailored by the type 1 and 2 deiodinase enzymes D2 and D3, which catalyze TH activation and inactivation respec...

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Veröffentlicht in:	Thyroid (New York, N.Y.) N.Y.), 2017-04, Vol.27 (4), p.567-576
Hauptverfasser:	Miro, Caterina, Ambrosio, Raffaele, De Stefano, Maria Angela, Di Girolamo, Daniela, Di Cicco, Emery, Cicatiello, Annunziata Gaetana, Mancino, Giuseppina, Porcelli, Tommaso, Raia, Maddalena, Del Vecchio, Luigi, Salvatore, Domenico, Dentice, Monica
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - genetics Carcinoma, Basal Cell - genetics Carcinoma, Basal Cell - metabolism Cell Cycle - genetics Cell Death - genetics Cell Survival - genetics CRISPR-Cas Systems Cyclin D1 Flow Cytometry G1 Phase Cell Cycle Checkpoints - genetics Iodide Peroxidase - genetics Iodothyronine Deiodinase Type II Mice Mice, Transgenic Mutagenesis, Site-Directed Skin Neoplasms - genetics Skin Neoplasms - metabolism Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action Thyroid Hormones - metabolism
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