Changes of Metabolic Phenotype of Cardiac Progenitor Cells During Differentiation: Neutral Effect of Stimulation of AMP-Activated Protein Kinase

Cardiac progenitor cells (CPCs) in the adult mammalian heart, as well as exogenous CPCs injected at the border zone of infarcted tissue, display very low differentiation rate into cardiac myocytes and marginal repair capacity in the injured heart. Emerging evidence supports an obligatory metabolic s...

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Veröffentlicht in:	Stem cells and development 2019-11, Vol.28 (22), p.1498-1513
Hauptverfasser:	André, Emilie, De Pauw, Aurélia, Verdoy, Roxane, Brusa, Davide, Bouzin, Caroline, Timmermans, Aurélie, Bertrand, Luc, Balligand, Jean-Luc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxin-1 - genetics Cell Differentiation - drug effects Cell Proliferation - drug effects Gene Expression Regulation, Developmental - drug effects Glucose - metabolism Glucose Transporter Type 1 - genetics Glutamine - metabolism Glycolysis - drug effects Heart Injuries - genetics Heart Injuries - metabolism Heart Injuries - pathology Heart Injuries - therapy Humans Mice Mitochondria - drug effects Mitochondria - genetics Monocarboxylic Acid Transporters - genetics Muscle Proteins - genetics Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial Infarction - therapy Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Original Research Reports Oxidative Phosphorylation - drug effects Phosphofructokinase-2 - genetics Protein Kinases - genetics Pyrones - pharmacology Rats Resveratrol - pharmacology Thiophenes - pharmacology
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