Redox signaling-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells

The regulation of cytokine gene transcription and biosynthesis involves the reduction-oxidation (redox)-sensitive nuclear factor-kappaB (NF-kappaB), whose activation is mediated by an upstream kinase that regulates the phosphorylation of inhibitory-kappaB (IkappaB). It was hypothesized that lipopoly...

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Veröffentlicht in:	Antioxidants & redox signaling 2002-02, Vol.4 (1), p.179-193
Hauptverfasser:	Haddad, John J, Land, Stephen C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - pharmacology Carmustine - pharmacology Cells, Cultured Cytokines - biosynthesis DNA-Binding Proteins - metabolism Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Glutathione - metabolism I-kappa B Proteins Lipopolysaccharides - metabolism NF-kappa B - metabolism NF-KappaB Inhibitor alpha Oxidation-Reduction Phosphorylation Pulmonary Alveoli - cytology Rats Rats, Sprague-Dawley Signal Transduction
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