Surface colonized silver nano particles over chitosan poly-electrolyte micro-spheres and their multi-functional behavior

Chitosan/tripolyphosphate polyelectrolyte (TPP) microspheres, decorated and surface functionalized with silver nanoparticles (NPs) of average diameter of 15 nm, were synthesized following a simple two-step procedure. These Ag NP-functionalized polyelectrolyte microspheres (Ag-CSPMs) are found to be...

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Veröffentlicht in:	Materials research express 2018-02, Vol.5 (2), p.25032
Hauptverfasser:	Prakash, B, Asha, S, Ananth, A Nimrodh, Vanithakumari, G, Okram, G S, Jose, Sujin P, Rajan, M A Jothi
Format:	Artikel
Sprache:	eng
Schlagworte:	antibacterial properties chitosan cytotoxicity reactive oxygen species silver nanoparticles theranostics
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description	Chitosan/tripolyphosphate polyelectrolyte (TPP) microspheres, decorated and surface functionalized with silver nanoparticles (NPs) of average diameter of 15 nm, were synthesized following a simple two-step procedure. These Ag NP-functionalized polyelectrolyte microspheres (Ag-CSPMs) are found to be biocompatible and enhancing the reactive oxygen species in curcumin with excellent anti-bacterial activity for selected Gram-positive and negative bacterial strains, making them much attractive relative to bare surface counterparts; the well-stabilized silver NPs do not form any agglomerations on the surface of the chitosan microspheres. They also show excellent cytotoxic behavior towards MCF7 cell lines, showing a half-maximal inhibitory concentration (IC50) of 32 g ml−1. Therefore, Ag-CSPMs exhibit multi-functional ability having potential towards theranostics applications.
doi_str_mv	10.1088/2053-1591/aaa3c6
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Res. Express</addtitle><date>2018-02-23</date><risdate>2018</risdate><volume>5</volume><issue>2</issue><spage>25032</spage><pages>25032-</pages><issn>2053-1591</issn><eissn>2053-1591</eissn><abstract>Chitosan/tripolyphosphate polyelectrolyte (TPP) microspheres, decorated and surface functionalized with silver nanoparticles (NPs) of average diameter of 15 nm, were synthesized following a simple two-step procedure. These Ag NP-functionalized polyelectrolyte microspheres (Ag-CSPMs) are found to be biocompatible and enhancing the reactive oxygen species in curcumin with excellent anti-bacterial activity for selected Gram-positive and negative bacterial strains, making them much attractive relative to bare surface counterparts; the well-stabilized silver NPs do not form any agglomerations on the surface of the chitosan microspheres. They also show excellent cytotoxic behavior towards MCF7 cell lines, showing a half-maximal inhibitory concentration (IC50) of 32 g ml−1. 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subjects	antibacterial properties chitosan cytotoxicity reactive oxygen species silver nanoparticles theranostics
title	Surface colonized silver nano particles over chitosan poly-electrolyte micro-spheres and their multi-functional behavior
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