Drug compound screening in single and integrated multi-organoid body-on-a-chip systems

Current practices in drug development have led to therapeutic compounds being approved for widespread use in humans, only to be later withdrawn due to unanticipated toxicity. These occurrences are largely the result of erroneous data generated by in vivo and in vitro preclinical models that do not a...

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Veröffentlicht in:Biofabrication 2020-02, Vol.12 (2), p.025017
Hauptverfasser: Skardal, Aleksander, Aleman, Julio, Forsythe, Steven, Rajan, Shiny, Murphy, Sean, Devarasetty, Mahesh, Pourhabibi Zarandi, Nima, Nzou, Goodwell, Wicks, Robert, Sadri-Ardekani, Hooman, Bishop, Colin, Soker, Shay, Hall, Adam, Shupe, Thomas, Atala, Anthony
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Sprache:eng
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