Cytotoxicity of novel hybrid composite materials for making bone fracture plates

Bone fracture plates are usually made from steel or titanium, which are much stiffer than cortical bone. This may cause bone "stress shielding" (i.e., bone resorption leading to plate loosening) and delayed fracture healing (i.e., fracture motion is less than needed to stimulate callus for...

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Veröffentlicht in:Biomedical materials (Bristol) 2024-07, Vol.19 (4), p.41001
Hauptverfasser: Bihari, Aurelia, Gee, Aaron, Bougherara, Habiba, Brzozowski, Pawel, Lawendy, Abdel-Rahman, Schemitsch, Emil H, Zdero, Radovan
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container_issue 4
container_start_page 41001
container_title Biomedical materials (Bristol)
container_volume 19
creator Bihari, Aurelia
Gee, Aaron
Bougherara, Habiba
Brzozowski, Pawel
Lawendy, Abdel-Rahman
Schemitsch, Emil H
Zdero, Radovan
description Bone fracture plates are usually made from steel or titanium, which are much stiffer than cortical bone. This may cause bone "stress shielding" (i.e., bone resorption leading to plate loosening) and delayed fracture healing (i.e., fracture motion is less than needed to stimulate callus formation at the fracture). Thus, the authors previously designed, fabricated, and mechanically tested novel "hybrid" composites made from inorganic and organic materials as potential bone fracture plates that are more flexible to reduce these negative effects. This is the first study to measure the cytotoxicity of these composites via the survival of rat cells. Cubes of carbon fiber/flax fiber/epoxy and glass fiber/flax fiber/epoxy had better cell survival vs. Kevlar fiber/flax fiber/epoxy (57% and 58% vs. 50%). Layers and powders made of carbon fiber/epoxy and glass fiber/epoxy had higher cell survival than Kevlar fiber/epoxy (96-100% and 100% vs. 39-90%). The presence of flax fibers usually decreased cell survival. Thus, carbon and glass fiber composites (with or without flax fibers), but not Kevlar fiber composites (with or without flax fibers), may potentially be used for bone fracture plates.
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subjects bone fracture
composites
cytotoxicity
hybrid
plates
title Cytotoxicity of novel hybrid composite materials for making bone fracture plates
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