Effects of protein-coated nanofibers on conformation of gingival fibroblast spheroids: potential utility for connective tissue regeneration

Deep wounds in the gingiva caused by trauma or surgery require a rapid and robust healing of connective tissues. We propose utilizing gas-brushed nanofibers coated with collagen and fibrin for that purpose. Our hypotheses are that protein-coated nanofibers will: (i) attract and mobilize cells in var...

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Veröffentlicht in:	Biomedical materials (Bristol) 2018-01, Vol.13 (2), p.025006-025006
Hauptverfasser:	Kaufman, Gili, Whitescarver, Ryan A, Nunes, Laiz, Palmer, Xavier-Lewis, Skrtic, Drago, Tutak, Wojtek
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Coated Materials, Biocompatible - chemistry collagen Collagen Type I - metabolism Connective Tissue - pathology Extracellular Matrix - metabolism fibrin Fibroblasts - cytology Fibronectins - metabolism g-brush Gases Gingiva - cytology Gingiva - pathology gingival fibroblasts Matrix Metalloproteinase 2 - metabolism Mice Microscopy, Confocal Microscopy, Phase-Contrast Nanofibers - chemistry Polylactic Acid-Polyglycolic Acid Copolymer - chemistry protein-coated nanofibers Rats Regeneration spheroids Spheroids, Cellular Tensile Strength Tissue Engineering - methods Tissue Scaffolds - chemistry
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