Cerenkov luminescence and PET imaging of 90 Y: capabilities and limitations in small animal applications
The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence Y detection limit determined from con...
Gespeichert in:
| Veröffentlicht in: | Physics in medicine & biology 2020-03, Vol.65 (6), p.065006 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 6 |
| container_start_page | 065006 |
| container_title | Physics in medicine & biology |
| container_volume | 65 |
| creator | Mitchell, Gregory S Lloyd, P N Thomas Cherry, Simon R |
| description | The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and
Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence
Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for
Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the
Y detection limit is approximately 3 orders of magnitude higher at 10 µCi. |
| doi_str_mv | 10.1088/1361-6560/ab7502 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1088_1361_6560_ab7502</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>32045899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1119-9a928e7e49d771ccaa2b0cb0e56914f644ff0f71e13cb747b98e7cd7c7918e933</originalsourceid><addsrcrecordid>eNpNkM1OwzAQhC0EoqVw54T8AqHexIljbqgqP1IlOJQDp8h21sXgOFHcIvH2pAQqTrPamVmtPkIugV0DK8s5ZAUkRV6wudIiZ-kRmR5Wx__mCTmL8Z0xgDLlp2SSpYznpZRT8rbAHsNH-0n9rnEBo8FgkKpQ0-flmrpGbVzY0NZSyejrDTWqU9p5t3UYf1LeNW6rtq4NkbpAY6O8H4yhOEjXeWdG85ycWOUjXvzqjLzcLdeLh2T1dP-4uF0lBgBkIpVMSxTIZS0EGKNUqpnRDPNCArcF59YyKwAhM1pwoeWQNrUwQkKJMstmhI13Td_G2KOtun54pv-qgFV7aNWeSrWnUo3QhsrVWOl2usH6UPijlH0DL6poWA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Cerenkov luminescence and PET imaging of 90 Y: capabilities and limitations in small animal applications</title><source>MEDLINE</source><source>IOP Publishing Journals</source><source>Institute of Physics (IOP) Journals - HEAL-Link</source><creator>Mitchell, Gregory S ; Lloyd, P N Thomas ; Cherry, Simon R</creator><creatorcontrib>Mitchell, Gregory S ; Lloyd, P N Thomas ; Cherry, Simon R</creatorcontrib><description>The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and
Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence
Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for
Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the
Y detection limit is approximately 3 orders of magnitude higher at 10 µCi.</description><identifier>ISSN: 1361-6560</identifier><identifier>EISSN: 1361-6560</identifier><identifier>DOI: 10.1088/1361-6560/ab7502</identifier><identifier>PMID: 32045899</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Electrons ; Luminescence ; Mice ; Phantoms, Imaging ; Positron-Emission Tomography - methods ; Yttrium Radioisotopes</subject><ispartof>Physics in medicine & biology, 2020-03, Vol.65 (6), p.065006</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1119-9a928e7e49d771ccaa2b0cb0e56914f644ff0f71e13cb747b98e7cd7c7918e933</citedby><cites>FETCH-LOGICAL-c1119-9a928e7e49d771ccaa2b0cb0e56914f644ff0f71e13cb747b98e7cd7c7918e933</cites><orcidid>0000-0002-8276-1107 ; 0000-0002-0155-5644 ; 0000-0002-4271-8809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32045899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitchell, Gregory S</creatorcontrib><creatorcontrib>Lloyd, P N Thomas</creatorcontrib><creatorcontrib>Cherry, Simon R</creatorcontrib><title>Cerenkov luminescence and PET imaging of 90 Y: capabilities and limitations in small animal applications</title><title>Physics in medicine & biology</title><addtitle>Phys Med Biol</addtitle><description>The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and
Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence
Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for
Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the
Y detection limit is approximately 3 orders of magnitude higher at 10 µCi.</description><subject>Animals</subject><subject>Electrons</subject><subject>Luminescence</subject><subject>Mice</subject><subject>Phantoms, Imaging</subject><subject>Positron-Emission Tomography - methods</subject><subject>Yttrium Radioisotopes</subject><issn>1361-6560</issn><issn>1361-6560</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwzAQhC0EoqVw54T8AqHexIljbqgqP1IlOJQDp8h21sXgOFHcIvH2pAQqTrPamVmtPkIugV0DK8s5ZAUkRV6wudIiZ-kRmR5Wx__mCTmL8Z0xgDLlp2SSpYznpZRT8rbAHsNH-0n9rnEBo8FgkKpQ0-flmrpGbVzY0NZSyejrDTWqU9p5t3UYf1LeNW6rtq4NkbpAY6O8H4yhOEjXeWdG85ycWOUjXvzqjLzcLdeLh2T1dP-4uF0lBgBkIpVMSxTIZS0EGKNUqpnRDPNCArcF59YyKwAhM1pwoeWQNrUwQkKJMstmhI13Td_G2KOtun54pv-qgFV7aNWeSrWnUo3QhsrVWOl2usH6UPijlH0DL6poWA</recordid><startdate>20200320</startdate><enddate>20200320</enddate><creator>Mitchell, Gregory S</creator><creator>Lloyd, P N Thomas</creator><creator>Cherry, Simon R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-8276-1107</orcidid><orcidid>https://orcid.org/0000-0002-0155-5644</orcidid><orcidid>https://orcid.org/0000-0002-4271-8809</orcidid></search><sort><creationdate>20200320</creationdate><title>Cerenkov luminescence and PET imaging of 90 Y: capabilities and limitations in small animal applications</title><author>Mitchell, Gregory S ; Lloyd, P N Thomas ; Cherry, Simon R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1119-9a928e7e49d771ccaa2b0cb0e56914f644ff0f71e13cb747b98e7cd7c7918e933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Electrons</topic><topic>Luminescence</topic><topic>Mice</topic><topic>Phantoms, Imaging</topic><topic>Positron-Emission Tomography - methods</topic><topic>Yttrium Radioisotopes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchell, Gregory S</creatorcontrib><creatorcontrib>Lloyd, P N Thomas</creatorcontrib><creatorcontrib>Cherry, Simon R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Physics in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchell, Gregory S</au><au>Lloyd, P N Thomas</au><au>Cherry, Simon R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerenkov luminescence and PET imaging of 90 Y: capabilities and limitations in small animal applications</atitle><jtitle>Physics in medicine & biology</jtitle><addtitle>Phys Med Biol</addtitle><date>2020-03-20</date><risdate>2020</risdate><volume>65</volume><issue>6</issue><spage>065006</spage><pages>065006-</pages><issn>1361-6560</issn><eissn>1361-6560</eissn><abstract>The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and
Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence
Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for
Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the
Y detection limit is approximately 3 orders of magnitude higher at 10 µCi.</abstract><cop>England</cop><pmid>32045899</pmid><doi>10.1088/1361-6560/ab7502</doi><orcidid>https://orcid.org/0000-0002-8276-1107</orcidid><orcidid>https://orcid.org/0000-0002-0155-5644</orcidid><orcidid>https://orcid.org/0000-0002-4271-8809</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1361-6560 |
| ispartof | Physics in medicine & biology, 2020-03, Vol.65 (6), p.065006 |
| issn | 1361-6560 1361-6560 |
| language | eng |
| recordid | cdi_crossref_primary_10_1088_1361_6560_ab7502 |
| source | MEDLINE; IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | Animals Electrons Luminescence Mice Phantoms, Imaging Positron-Emission Tomography - methods Yttrium Radioisotopes |
| title | Cerenkov luminescence and PET imaging of 90 Y: capabilities and limitations in small animal applications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A11%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerenkov%20luminescence%20and%20PET%20imaging%20of%2090%20Y:%20capabilities%20and%20limitations%20in%20small%20animal%20applications&rft.jtitle=Physics%20in%20medicine%20&%20biology&rft.au=Mitchell,%20Gregory%20S&rft.date=2020-03-20&rft.volume=65&rft.issue=6&rft.spage=065006&rft.pages=065006-&rft.issn=1361-6560&rft.eissn=1361-6560&rft_id=info:doi/10.1088/1361-6560/ab7502&rft_dat=%3Cpubmed_cross%3E32045899%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/32045899&rfr_iscdi=true |