The serine-threonine phosphatase calcineurin is a regulator of endothelial store-operated calcium entry

Disruption of the endothelium leads to increased permeability, allowing extravasation of macromolecules and other solutes from blood vessels. Calcium entry through a calcium-selective, store-operated calcium (SOC) channel, Isoc, contributes to barrier disruption. An understanding of the mechanisms s...

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Veröffentlicht in:	Pulmonary circulation 2014-03, Vol.4 (1), p.116-127
Hauptverfasser:	Vasauskas, Audrey A., Chen, Hairu, Wu, Songwei, Cioffi, Donna L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Calcium Cell membranes Endothelial cells Isoc Kinases Original Research Phosphatase Phosphatases Phosphorylation Physiological regulation Pulmonary arteries Pulmonary artery Small interfering RNA STIM1 stromal interaction molecule 1 T lymphocytes transient receptor potential TRPC
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