A Randomized Factorial Trial Comparing 4 Treatment Regimens in Treatment-Naive HIV-Infected Persons with AIDS and/or a CD4 Cell Count <200 Cells/μL in South Africa

Few randomized trials comparing antiretroviral therapy (ART) regimens have been conducted in resource-limited settings. In the Republic of South Africa, antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals >14 years old with a CD4 cell count

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Veröffentlicht in:	The Journal of infectious diseases 2010-11, Vol.202 (10), p.1529-1537
Hauptverfasser:	Ratsela, Andrew, Polis, Michael, Dhlomo, Sibongiseni, Emery, Sean, Grandits, Greg, Khabo, Paul, Khanyile, Thandeka, Komati, Stephanus, Neaton, James D, Naidoo, Lionel Chris David, Magongoa, Daphne, Qolohle, Duma
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - complications Acquired Immunodeficiency Syndrome - drug therapy Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - virology Adult Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Benzoxazines - therapeutic use Biological and medical sciences CD4 Lymphocyte Count Didanosine - adverse effects Didanosine - therapeutic use Drug Therapy, Combination Female HIV - genetics Human viral diseases Humans Infectious diseases Lamivudine - adverse effects Lamivudine - therapeutic use Lopinavir Male Medical sciences Pyrimidinones - therapeutic use Ritonavir - therapeutic use RNA, Viral - blood South Africa Stavudine - adverse effects Stavudine - therapeutic use Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Zidovudine - adverse effects Zidovudine - therapeutic use
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Beschreibung
Zusammenfassung:	Few randomized trials comparing antiretroviral therapy (ART) regimens have been conducted in resource-limited settings. In the Republic of South Africa, antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals >14 years old with a CD4 cell count
ISSN:	0022-1899 1537-6613
DOI:	10.1086/656718