ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION
LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57...
Gespeichert in:
| Veröffentlicht in: | Immunopharmacology and immunotoxicology 2001-01, Vol.23 (3), p.307-319 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 319 |
|---|---|
| container_issue | 3 |
| container_start_page | 307 |
| container_title | Immunopharmacology and immunotoxicology |
| container_volume | 23 |
| creator | Liang, Bailin Jiang, Shuguang Zhang, Zhen Inserra, Paula Lee, Jeongmin Solkoff, David Watson, Ronald R. |
| description | LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL 6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment. |
| doi_str_mv | 10.1081/IPH-100107332 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1081_IPH_100107332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18212189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-86c7bc1941d4a29553930e4696a8f5e18b20b331066da103711228ed0a5ee9833</originalsourceid><addsrcrecordid>eNqF0c1v0zAYB2ALgVgZHLkiX-CW4dfOh80t6pzVIh9TmyDtFLmJo3VKm2K3Qvvvl9DCxGHiZMl-3g_5h9BHIFdAOHxVtwsPCAESMUZfoRkEjHo0APYazQgX1GMiYhfonXMPoxIRCd6iC4BQ-ISyGdrHeak8lSdpnGVxWSzvsEwSOS9XuEhwuZDF7eIuTVUuv-GsuK7SuFRFPr2pLKtyiZMqn09XK3xdLVV-g7PpkDiV1XeZqRj_UMtqhccJ8rd7j950unfmw_m8RFUiy_nCS4sbNY9Tr_H96ODxsInWDQgfWl9TEQRMMGL8UISad4EBvqZkzRiQMGw1EBYBUMpNS3RgjOCMXaIvp757O_w8GneotxvXmL7XOzMcXR1R6gPx4b8QOAUKXIzQO8HGDs5Z09V7u9lq-1gDqacs6jGL-m8Wo_90bnxcb037rM-fP4LPZ6Bdo_vO6l2zcc-OcR7RcBrMT26z6wa71b8G27f1QT_2g_1TxF7aIfqn9N7o_nDfaGvqh-Fod2MCL2z_BA6pqmo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18212189</pqid></control><display><type>article</type><title>ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Access via Taylor & Francis</source><creator>Liang, Bailin ; Jiang, Shuguang ; Zhang, Zhen ; Inserra, Paula ; Lee, Jeongmin ; Solkoff, David ; Watson, Ronald R.</creator><creatorcontrib>Liang, Bailin ; Jiang, Shuguang ; Zhang, Zhen ; Inserra, Paula ; Lee, Jeongmin ; Solkoff, David ; Watson, Ronald R.</creatorcontrib><description>LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL 6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.</description><identifier>ISSN: 0892-3973</identifier><identifier>EISSN: 1532-2513</identifier><identifier>DOI: 10.1081/IPH-100107332</identifier><identifier>PMID: 11694023</identifier><identifier>CODEN: IITOEF</identifier><language>eng</language><publisher>Monticello, NY: Informa UK Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Apoptosis ; Apoptosis - drug effects ; B-Lymphocytes - drug effects ; B-Lymphocytes - immunology ; B-Lymphocytes - pathology ; Biological and medical sciences ; Bones, joints and connective tissue. Antiinflammatory agents ; Cytokine ; Cytokines - biosynthesis ; Female ; Immune dysfunction ; Leukemia Virus, Murine ; Leukemia, Experimental - drug therapy ; Leukemia, Experimental - immunology ; Leukemia, Experimental - pathology ; Lymphocyte Activation - drug effects ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Murine leukemia virus ; Murine retrovirus ; Pharmacology. Drug treatments ; Retroviridae Infections - drug therapy ; Retroviridae Infections - immunology ; Retroviridae Infections - pathology ; Spleen - drug effects ; Spleen - immunology ; Spleen - pathology ; T and B cell proliferation ; T-Lymphocytes - drug effects ; T-Lymphocytes - immunology ; T-Lymphocytes - pathology ; theophylline ; Theophylline - pharmacology ; Tumor Virus Infections - drug therapy ; Tumor Virus Infections - immunology ; Tumor Virus Infections - pathology</subject><ispartof>Immunopharmacology and immunotoxicology, 2001-01, Vol.23 (3), p.307-319</ispartof><rights>2001 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2001</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-86c7bc1941d4a29553930e4696a8f5e18b20b331066da103711228ed0a5ee9833</citedby><cites>FETCH-LOGICAL-c447t-86c7bc1941d4a29553930e4696a8f5e18b20b331066da103711228ed0a5ee9833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/IPH-100107332$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/IPH-100107332$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,59652,59758,60441,60547,61226,61261,61407,61442</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13887269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11694023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Bailin</creatorcontrib><creatorcontrib>Jiang, Shuguang</creatorcontrib><creatorcontrib>Zhang, Zhen</creatorcontrib><creatorcontrib>Inserra, Paula</creatorcontrib><creatorcontrib>Lee, Jeongmin</creatorcontrib><creatorcontrib>Solkoff, David</creatorcontrib><creatorcontrib>Watson, Ronald R.</creatorcontrib><title>ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION</title><title>Immunopharmacology and immunotoxicology</title><addtitle>Immunopharmacol Immunotoxicol</addtitle><description>LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL 6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Cytokine</subject><subject>Cytokines - biosynthesis</subject><subject>Female</subject><subject>Immune dysfunction</subject><subject>Leukemia Virus, Murine</subject><subject>Leukemia, Experimental - drug therapy</subject><subject>Leukemia, Experimental - immunology</subject><subject>Leukemia, Experimental - pathology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Murine leukemia virus</subject><subject>Murine retrovirus</subject><subject>Pharmacology. Drug treatments</subject><subject>Retroviridae Infections - drug therapy</subject><subject>Retroviridae Infections - immunology</subject><subject>Retroviridae Infections - pathology</subject><subject>Spleen - drug effects</subject><subject>Spleen - immunology</subject><subject>Spleen - pathology</subject><subject>T and B cell proliferation</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - pathology</subject><subject>theophylline</subject><subject>Theophylline - pharmacology</subject><subject>Tumor Virus Infections - drug therapy</subject><subject>Tumor Virus Infections - immunology</subject><subject>Tumor Virus Infections - pathology</subject><issn>0892-3973</issn><issn>1532-2513</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1v0zAYB2ALgVgZHLkiX-CW4dfOh80t6pzVIh9TmyDtFLmJo3VKm2K3Qvvvl9DCxGHiZMl-3g_5h9BHIFdAOHxVtwsPCAESMUZfoRkEjHo0APYazQgX1GMiYhfonXMPoxIRCd6iC4BQ-ISyGdrHeak8lSdpnGVxWSzvsEwSOS9XuEhwuZDF7eIuTVUuv-GsuK7SuFRFPr2pLKtyiZMqn09XK3xdLVV-g7PpkDiV1XeZqRj_UMtqhccJ8rd7j950unfmw_m8RFUiy_nCS4sbNY9Tr_H96ODxsInWDQgfWl9TEQRMMGL8UISad4EBvqZkzRiQMGw1EBYBUMpNS3RgjOCMXaIvp757O_w8GneotxvXmL7XOzMcXR1R6gPx4b8QOAUKXIzQO8HGDs5Z09V7u9lq-1gDqacs6jGL-m8Wo_90bnxcb037rM-fP4LPZ6Bdo_vO6l2zcc-OcR7RcBrMT26z6wa71b8G27f1QT_2g_1TxF7aIfqn9N7o_nDfaGvqh-Fod2MCL2z_BA6pqmo</recordid><startdate>20010101</startdate><enddate>20010101</enddate><creator>Liang, Bailin</creator><creator>Jiang, Shuguang</creator><creator>Zhang, Zhen</creator><creator>Inserra, Paula</creator><creator>Lee, Jeongmin</creator><creator>Solkoff, David</creator><creator>Watson, Ronald R.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010101</creationdate><title>ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION</title><author>Liang, Bailin ; Jiang, Shuguang ; Zhang, Zhen ; Inserra, Paula ; Lee, Jeongmin ; Solkoff, David ; Watson, Ronald R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-86c7bc1941d4a29553930e4696a8f5e18b20b331066da103711228ed0a5ee9833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Bones, joints and connective tissue. Antiinflammatory agents</topic><topic>Cytokine</topic><topic>Cytokines - biosynthesis</topic><topic>Female</topic><topic>Immune dysfunction</topic><topic>Leukemia Virus, Murine</topic><topic>Leukemia, Experimental - drug therapy</topic><topic>Leukemia, Experimental - immunology</topic><topic>Leukemia, Experimental - pathology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Murine leukemia virus</topic><topic>Murine retrovirus</topic><topic>Pharmacology. Drug treatments</topic><topic>Retroviridae Infections - drug therapy</topic><topic>Retroviridae Infections - immunology</topic><topic>Retroviridae Infections - pathology</topic><topic>Spleen - drug effects</topic><topic>Spleen - immunology</topic><topic>Spleen - pathology</topic><topic>T and B cell proliferation</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - pathology</topic><topic>theophylline</topic><topic>Theophylline - pharmacology</topic><topic>Tumor Virus Infections - drug therapy</topic><topic>Tumor Virus Infections - immunology</topic><topic>Tumor Virus Infections - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Bailin</creatorcontrib><creatorcontrib>Jiang, Shuguang</creatorcontrib><creatorcontrib>Zhang, Zhen</creatorcontrib><creatorcontrib>Inserra, Paula</creatorcontrib><creatorcontrib>Lee, Jeongmin</creatorcontrib><creatorcontrib>Solkoff, David</creatorcontrib><creatorcontrib>Watson, Ronald R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunopharmacology and immunotoxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Bailin</au><au>Jiang, Shuguang</au><au>Zhang, Zhen</au><au>Inserra, Paula</au><au>Lee, Jeongmin</au><au>Solkoff, David</au><au>Watson, Ronald R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION</atitle><jtitle>Immunopharmacology and immunotoxicology</jtitle><addtitle>Immunopharmacol Immunotoxicol</addtitle><date>2001-01-01</date><risdate>2001</risdate><volume>23</volume><issue>3</issue><spage>307</spage><epage>319</epage><pages>307-319</pages><issn>0892-3973</issn><eissn>1532-2513</eissn><coden>IITOEF</coden><abstract>LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL 6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.</abstract><cop>Monticello, NY</cop><pub>Informa UK Ltd</pub><pmid>11694023</pmid><doi>10.1081/IPH-100107332</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0892-3973 |
| ispartof | Immunopharmacology and immunotoxicology, 2001-01, Vol.23 (3), p.307-319 |
| issn | 0892-3973 1532-2513 |
| language | eng |
| recordid | cdi_crossref_primary_10_1081_IPH_100107332 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Access via Taylor & Francis |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Apoptosis Apoptosis - drug effects B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - pathology Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cytokine Cytokines - biosynthesis Female Immune dysfunction Leukemia Virus, Murine Leukemia, Experimental - drug therapy Leukemia, Experimental - immunology Leukemia, Experimental - pathology Lymphocyte Activation - drug effects Medical sciences Mice Mice, Inbred C57BL Murine leukemia virus Murine retrovirus Pharmacology. Drug treatments Retroviridae Infections - drug therapy Retroviridae Infections - immunology Retroviridae Infections - pathology Spleen - drug effects Spleen - immunology Spleen - pathology T and B cell proliferation T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - pathology theophylline Theophylline - pharmacology Tumor Virus Infections - drug therapy Tumor Virus Infections - immunology Tumor Virus Infections - pathology |
| title | ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T00%3A46%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=ANTI-INFLAMMATORY%20EFFECTS%20OF%20THEOPHYLLINE:%20MODULATION%20OF%20IMMUNE%20FUNCTIONS%20DURING%20MURINE%20LEUKEMIA%20VIRUS%20INFECTION&rft.jtitle=Immunopharmacology%20and%20immunotoxicology&rft.au=Liang,%20Bailin&rft.date=2001-01-01&rft.volume=23&rft.issue=3&rft.spage=307&rft.epage=319&rft.pages=307-319&rft.issn=0892-3973&rft.eissn=1532-2513&rft.coden=IITOEF&rft_id=info:doi/10.1081/IPH-100107332&rft_dat=%3Cproquest_cross%3E18212189%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=18212189&rft_id=info:pmid/11694023&rfr_iscdi=true |