ASSESSING PREGNANCY RISKS OF AZOLE ANTIFUNGALS USING A HIGH THROUGHPUT AROMATASE INHIBITION ASSAY

Human aromatase (CYP19) converts C19 androgens to aromatic C18 estrogenic steroids. Its activity is critical for early and mid pregnancy maintenance and in regulating parturition in late pregnancy. Past studies have utilized placental microsome tritiated water release assay to assess drug-hormone in...

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Veröffentlicht in:	Endocrine research 2002-01, Vol.28 (3), p.129-140
Hauptverfasser:	Kragie, Laura, Turner, Stephanie D., Patten, Christopher J., Crespi, Charles L., Stresser, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antifungal Agents - adverse effects Aromatase Inhibitors Baculoviridae Female Humans Imidazoles - adverse effects Inhibitory Concentration 50 Insecta Microsomes - enzymology Placenta - enzymology Pregnancy - drug effects Pregnancy - metabolism
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