STRUCTURAL BIOLOGY AND FUNCTION OF SOLUTE TRANSPORTERS: IMPLICATIONS FOR IDENTIFYING AND DESIGNING SUBSTRATES
Solute carrier (SLC) proteins have critical physiological roles in nutrient transport and may be utilized as a mechanism to increase drug absorption. However, we have little understanding of these proteins at the molecular level due to the absence of high-resolution crystal structures. Numerous effo...
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| Veröffentlicht in: | Drug metabolism reviews 2002-01, Vol.34 (4), p.709-750 |
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| container_title | Drug metabolism reviews |
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| creator | Zhang, Eric Y. Knipp, Gregory T. Ekins, Sean Swaan, Peter W. |
| description | Solute carrier (SLC) proteins have critical physiological roles in nutrient transport and may be utilized as a mechanism to increase drug absorption. However, we have little understanding of these proteins at the molecular level due to the absence of high-resolution crystal structures. Numerous efforts have been made in characterizing the peptide transporter (PepT1) and the apical sodium dependent bile acid transporter (ASBT) that are important for both their native transporter function as well as targets to increase absorption and act as therapeutic targets. In vitro and computational approaches have been applied to gain some insight into these transporters with some success. This represents an opportunity for optimizing molecules as substrates for the solute transporters and providing a further screening system for drug discovery. Clearly the future growth in knowledge of SLC function will be led by integrated in vitro and in silico approaches. |
| doi_str_mv | 10.1081/DMR-120015692 |
| format | Article |
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Psychology ; Humans ; Membrane and intracellular transports ; Membrane Transport Proteins - chemical synthesis ; Membrane Transport Proteins - chemistry ; Membrane Transport Proteins - physiology ; Molecular and cellular biology ; Molecular Sequence Data ; P-glycoprotein ; Peptide transport ; Structure activity</subject><ispartof>Drug metabolism reviews, 2002-01, Vol.34 (4), p.709-750</ispartof><rights>2002 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2002</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-48c8ab63a699bc47196f30c167fb82e183092c40bb9e43c2ab466c93e2695c503</citedby><cites>FETCH-LOGICAL-c416t-48c8ab63a699bc47196f30c167fb82e183092c40bb9e43c2ab466c93e2695c503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/DMR-120015692$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/DMR-120015692$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,59646,59752,60435,60541,61220,61255,61401,61436</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14375220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12487148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Eric Y.</creatorcontrib><creatorcontrib>Knipp, Gregory T.</creatorcontrib><creatorcontrib>Ekins, Sean</creatorcontrib><creatorcontrib>Swaan, Peter W.</creatorcontrib><title>STRUCTURAL BIOLOGY AND FUNCTION OF SOLUTE TRANSPORTERS: IMPLICATIONS FOR IDENTIFYING AND DESIGNING SUBSTRATES</title><title>Drug metabolism reviews</title><addtitle>Drug Metab Rev</addtitle><description>Solute carrier (SLC) proteins have critical physiological roles in nutrient transport and may be utilized as a mechanism to increase drug absorption. However, we have little understanding of these proteins at the molecular level due to the absence of high-resolution crystal structures. Numerous efforts have been made in characterizing the peptide transporter (PepT1) and the apical sodium dependent bile acid transporter (ASBT) that are important for both their native transporter function as well as targets to increase absorption and act as therapeutic targets. In vitro and computational approaches have been applied to gain some insight into these transporters with some success. This represents an opportunity for optimizing molecules as substrates for the solute transporters and providing a further screening system for drug discovery. Clearly the future growth in knowledge of SLC function will be led by integrated in vitro and in silico approaches.</description><subject>Amino Acid Sequence - physiology</subject><subject>Animals</subject><subject>Bile acid</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - chemical synthesis</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - physiology</subject><subject>Cell physiology</subject><subject>Drug Design</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Membrane and intracellular transports</subject><subject>Membrane Transport Proteins - chemical synthesis</subject><subject>Membrane Transport Proteins - chemistry</subject><subject>Membrane Transport Proteins - physiology</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>P-glycoprotein</subject><subject>Peptide transport</subject><subject>Structure activity</subject><issn>0360-2532</issn><issn>1097-9883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtv2zAURomiReMkHbsWWtpNLV_io5tiS64ARQr0GDIRFEMhDiQrJW0E-feVa7dBhkwXFzj3ux8OAJ8R_I6gQD9W11WIMIQoYhK_AwsEJQ-lEOQ9WEDCYIgjgs_AufcPM4RlxD-CM4Sp4IiKBRjrpmqXTVvFeXCVlXm5vg3iYhWkbbFssrIIyjSoy7xtkqCp4qK-KasmqeqfQXZ9k2fL-MDUQVpWQbZKiiZLb7Ni_TdhldTZujhsdXs1f4mbpL4EH3o9ePvpNC9AmybN8lc4_53D8tBQxHYhFUbojhHNpOwM5UiynkCDGO87gS0SBEpsKOw6aSkxWHeUMSOJxUxGJoLkAnw75j666ffe-p0aN97YYdBbO-294pgLwrmcwfAIGjd572yvHt1m1O5ZIagOftXsV_33O_NfTsH7brR3L_RJ6Ax8PQHaGz30Tm_Nxr9wlPAI40NDceQ2235yo36a3HCndvp5mNy_I_JWB_7q9N7qYXdvtLPqYdq77Sz2jfZ_APRPnW4</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Zhang, Eric Y.</creator><creator>Knipp, Gregory T.</creator><creator>Ekins, Sean</creator><creator>Swaan, Peter W.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Informa Healthcare</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>STRUCTURAL BIOLOGY AND FUNCTION OF SOLUTE TRANSPORTERS: IMPLICATIONS FOR IDENTIFYING AND DESIGNING SUBSTRATES</title><author>Zhang, Eric Y. ; Knipp, Gregory T. ; Ekins, Sean ; Swaan, Peter W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-48c8ab63a699bc47196f30c167fb82e183092c40bb9e43c2ab466c93e2695c503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Amino Acid Sequence - physiology</topic><topic>Animals</topic><topic>Bile acid</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - chemical synthesis</topic><topic>Carrier Proteins - chemistry</topic><topic>Carrier Proteins - physiology</topic><topic>Cell physiology</topic><topic>Drug Design</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Membrane and intracellular transports</topic><topic>Membrane Transport Proteins - chemical synthesis</topic><topic>Membrane Transport Proteins - chemistry</topic><topic>Membrane Transport Proteins - physiology</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>P-glycoprotein</topic><topic>Peptide transport</topic><topic>Structure activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Eric Y.</creatorcontrib><creatorcontrib>Knipp, Gregory T.</creatorcontrib><creatorcontrib>Ekins, Sean</creatorcontrib><creatorcontrib>Swaan, Peter W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug metabolism reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Eric Y.</au><au>Knipp, Gregory T.</au><au>Ekins, Sean</au><au>Swaan, Peter W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STRUCTURAL BIOLOGY AND FUNCTION OF SOLUTE TRANSPORTERS: IMPLICATIONS FOR IDENTIFYING AND DESIGNING SUBSTRATES</atitle><jtitle>Drug metabolism reviews</jtitle><addtitle>Drug Metab Rev</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>34</volume><issue>4</issue><spage>709</spage><epage>750</epage><pages>709-750</pages><issn>0360-2532</issn><eissn>1097-9883</eissn><coden>DMTRAR</coden><abstract>Solute carrier (SLC) proteins have critical physiological roles in nutrient transport and may be utilized as a mechanism to increase drug absorption. However, we have little understanding of these proteins at the molecular level due to the absence of high-resolution crystal structures. Numerous efforts have been made in characterizing the peptide transporter (PepT1) and the apical sodium dependent bile acid transporter (ASBT) that are important for both their native transporter function as well as targets to increase absorption and act as therapeutic targets. In vitro and computational approaches have been applied to gain some insight into these transporters with some success. This represents an opportunity for optimizing molecules as substrates for the solute transporters and providing a further screening system for drug discovery. Clearly the future growth in knowledge of SLC function will be led by integrated in vitro and in silico approaches.</abstract><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>12487148</pmid><doi>10.1081/DMR-120015692</doi><tpages>42</tpages></addata></record> |
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| identifier | ISSN: 0360-2532 |
| ispartof | Drug metabolism reviews, 2002-01, Vol.34 (4), p.709-750 |
| issn | 0360-2532 1097-9883 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Amino Acid Sequence - physiology Animals Bile acid Biological and medical sciences Carrier Proteins - chemical synthesis Carrier Proteins - chemistry Carrier Proteins - physiology Cell physiology Drug Design Fundamental and applied biological sciences. Psychology Humans Membrane and intracellular transports Membrane Transport Proteins - chemical synthesis Membrane Transport Proteins - chemistry Membrane Transport Proteins - physiology Molecular and cellular biology Molecular Sequence Data P-glycoprotein Peptide transport Structure activity |
| title | STRUCTURAL BIOLOGY AND FUNCTION OF SOLUTE TRANSPORTERS: IMPLICATIONS FOR IDENTIFYING AND DESIGNING SUBSTRATES |
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