Nimesulide-Modified Gum Karaya Solid Mixtures: Preparation, Characterization, and Formulation Development

Abstract Solid mixtures of nimesulide (NS) and modified gum karaya (MGK) were prepared to improve the dissolution rate of NS. The effect of drug-carrier ratio on dissolution rate of NS was investigated by preparing the solid mixtures of different ratios by cogrinding method. Solid mixtures were also...

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Veröffentlicht in:	Drug development and industrial pharmacy 2003-01, Vol.29 (8), p.855-864
Hauptverfasser:	Murali Mohan Babu, G. V., Ravi Kumar, N., Himasankar, K., Seshasayana, A., Ramana Murthy, K. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Pharmaceutic - chemistry Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Calorimetry, Differential Scanning Chemistry, Pharmaceutical Dissolution enhancement General pharmacology Karaya Gum - chemistry Medical sciences Modified gum karaya Nimesulide Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solid mixtures Solubility Sulfonamides - administration & dosage Sulfonamides - chemistry Tablets X-Ray Diffraction
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