A Nifedipine Coground Mixture with Sodium Deoxycholate. II. Dissolution Characteristics and Stability

Nifedipine is a poorly water soluble drug that demonstrates low bioavailability. In a previous study, a coground mixture of nifedipine with sodium deoxycholate (DCNa), a bile salt, immediately produced colloidal particles when dispersed in water. In this study, the effect of the weight fraction of D...

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Veröffentlicht in:	Drug development and industrial pharmacy 2001-01, Vol.27 (9), p.951-958
Hauptverfasser:	Suzuki, Hideshi, Ogawa, Masahiro, Hironaka, Kenji, Ito, Kunio, Sunada, Hisakazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, High Pressure Liquid Coground mixture Colloidal particle Crystallization Deoxycholic Acid - chemistry Drug Compounding Drug Stability Drug Storage General pharmacology Humidity Medical sciences Nifedipine Nifedipine - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Sodium deoxycholate Solubility X-Ray Diffraction
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