In Vitro Release Behavior of Toremifene Citrate from Sol-Gel Processed Sintered Silica Xerogels
Factors affecting the adsorption and desorption of toremifene citrate (TC) on sintered silica xerogels were investigated in vitro. TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1999-01, Vol.25 (8), p.955-959 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Ahola, Manja Kortesuo, Pirjo Kangasniemi, Ilkka Kiesvaara, Juha Yli-Urpo, Antti |
| description | Factors affecting the adsorption and desorption of toremifene citrate (TC) on sintered silica xerogels were investigated in vitro. TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results support the conclusion that large pore size results in highest drug adsorption. Adsorption of TC was most effective in xerogels sintered at 700°C and containing the largest pores and lowest specific surface area of the silica xerogels studied in the adsorption tests. The release of TC from the xerogel matrix was linear with respect to the square root of time. The release of TC from the grains was very rapid for the first 5 hr, followed by a slower release. All drug was released from the grains, and 60% to 80% was released from the disks in 24 hr. All drug-silica xerogel formulations showed sustained in vitro release profiles. |
| doi_str_mv | 10.1081/DDC-100102257 |
| format | Article |
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TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results support the conclusion that large pore size results in highest drug adsorption. Adsorption of TC was most effective in xerogels sintered at 700°C and containing the largest pores and lowest specific surface area of the silica xerogels studied in the adsorption tests. The release of TC from the xerogel matrix was linear with respect to the square root of time. The release of TC from the grains was very rapid for the first 5 hr, followed by a slower release. All drug was released from the grains, and 60% to 80% was released from the disks in 24 hr. All drug-silica xerogel formulations showed sustained in vitro release profiles.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.1081/DDC-100102257</identifier><identifier>PMID: 10434140</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Adsorption ; Antineoplastic Agents, Hormonal - administration & dosage ; Biological and medical sciences ; Crystallization ; Drug Carriers ; Estrogen Antagonists - administration & dosage ; Gels ; General pharmacology ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results support the conclusion that large pore size results in highest drug adsorption. Adsorption of TC was most effective in xerogels sintered at 700°C and containing the largest pores and lowest specific surface area of the silica xerogels studied in the adsorption tests. The release of TC from the xerogel matrix was linear with respect to the square root of time. The release of TC from the grains was very rapid for the first 5 hr, followed by a slower release. All drug was released from the grains, and 60% to 80% was released from the disks in 24 hr. All drug-silica xerogel formulations showed sustained in vitro release profiles.</description><subject>Adsorption</subject><subject>Antineoplastic Agents, Hormonal - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Crystallization</subject><subject>Drug Carriers</subject><subject>Estrogen Antagonists - administration & dosage</subject><subject>Gels</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Porosity</subject><subject>Silicon Dioxide</subject><subject>Solubility</subject><subject>Spectrophotometry, Infrared</subject><subject>Surface Properties</subject><subject>Toremifene - administration & dosage</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1v1DAQBmALUdFl4cgV-YC4hdpxnKyPsP2gUiUQLYibNXHGrCsnLuNsq_57DLt8HXqyD8-8Hr-MvZDijRQreXR8vK6kEFLUte4esYXUtah019aP2UKoVlVGNPqQPc35uqjaaP2EHUrRqEY2YsHs-cS_hJkS_4QRISN_hxu4DYl48vwqEY7B44R8XRDMyD2lkV-mWJ1h5B8pOcwZB34Zphnp1yUGB_wrUvqGMT9jBx5ixuf7c8k-n55crd9XFx_OztdvLyrXSD1XqpeiBz-gkQJd57XRXvRNbZSpvZMgjFn1oKCX6P2gBhhM61sj2r58qNNOLdnrXe4Npe9bzLMdQ3YYI0yYttm2xiipW1FgtYOOUs6E3t5QGIHurRT2Z6O2NGr_NFr8y33wth9x-EfvKizg1R5AdhA9weRC_utMiSqPL9lqx8LkE41wlygOdob7mOj3jHpohe6_0Q1CnDcOCO112tJUen1g-R-FQaHu</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Ahola, Manja</creator><creator>Kortesuo, Pirjo</creator><creator>Kangasniemi, Ilkka</creator><creator>Kiesvaara, Juha</creator><creator>Yli-Urpo, Antti</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990101</creationdate><title>In Vitro Release Behavior of Toremifene Citrate from Sol-Gel Processed Sintered Silica Xerogels</title><author>Ahola, Manja ; Kortesuo, Pirjo ; Kangasniemi, Ilkka ; Kiesvaara, Juha ; Yli-Urpo, Antti</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-3b10bafde910ec7f595f0b429392fc1a0998ba3ab1effd3dad96f6906b95575c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adsorption</topic><topic>Antineoplastic Agents, Hormonal - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Crystallization</topic><topic>Drug Carriers</topic><topic>Estrogen Antagonists - administration & dosage</topic><topic>Gels</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Porosity</topic><topic>Silicon Dioxide</topic><topic>Solubility</topic><topic>Spectrophotometry, Infrared</topic><topic>Surface Properties</topic><topic>Toremifene - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahola, Manja</creatorcontrib><creatorcontrib>Kortesuo, Pirjo</creatorcontrib><creatorcontrib>Kangasniemi, Ilkka</creatorcontrib><creatorcontrib>Kiesvaara, Juha</creatorcontrib><creatorcontrib>Yli-Urpo, Antti</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahola, Manja</au><au>Kortesuo, Pirjo</au><au>Kangasniemi, Ilkka</au><au>Kiesvaara, Juha</au><au>Yli-Urpo, Antti</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Release Behavior of Toremifene Citrate from Sol-Gel Processed Sintered Silica Xerogels</atitle><jtitle>Drug development and industrial pharmacy</jtitle><addtitle>Drug Dev Ind Pharm</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>25</volume><issue>8</issue><spage>955</spage><epage>959</epage><pages>955-959</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Factors affecting the adsorption and desorption of toremifene citrate (TC) on sintered silica xerogels were investigated in vitro. TC was attached onto sol-gel processed sintered silica xerogel grains or disks by adsorption. The adsorption of TC on the surface of silica was pH dependent. The results support the conclusion that large pore size results in highest drug adsorption. Adsorption of TC was most effective in xerogels sintered at 700°C and containing the largest pores and lowest specific surface area of the silica xerogels studied in the adsorption tests. The release of TC from the xerogel matrix was linear with respect to the square root of time. The release of TC from the grains was very rapid for the first 5 hr, followed by a slower release. All drug was released from the grains, and 60% to 80% was released from the disks in 24 hr. All drug-silica xerogel formulations showed sustained in vitro release profiles.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><pmid>10434140</pmid><doi>10.1081/DDC-100102257</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9045 |
| ispartof | Drug development and industrial pharmacy, 1999-01, Vol.25 (8), p.955-959 |
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| language | eng |
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| source | MEDLINE; Business Source Complete; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adsorption Antineoplastic Agents, Hormonal - administration & dosage Biological and medical sciences Crystallization Drug Carriers Estrogen Antagonists - administration & dosage Gels General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Silicon Dioxide Solubility Spectrophotometry, Infrared Surface Properties Toremifene - administration & dosage |
| title | In Vitro Release Behavior of Toremifene Citrate from Sol-Gel Processed Sintered Silica Xerogels |
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