Pre- and Postoperative Aminoacidemia in Breast Cancer: A Study vs. Matched Healthy Subjects
Various alterations of aminoacidemia have been described during breast cancer. The aim of this study was first to establish the specific modifications of plasma-free amino acid concentrations by a comparative study of 19 patients with mammary tumors and 18 healthy volunteers, and, second, to determi...
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| Veröffentlicht in: | Cancer investigation 2004, Vol.22 (2), p.203-210 |
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| container_title | Cancer investigation |
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| creator | Minet-Quinard, Régine Van Praagh, Isabelle Kwiatkowski, Fabrice Beaujon, Guy Feillel, Viviane Beaufrère, Bernard Bargnoux, Pierre-Jean Cynober, Luc Vasson, Marie-Paule |
| description | Various alterations of aminoacidemia have been described during breast cancer. The aim of this study was first to establish the specific modifications of plasma-free amino acid concentrations by a comparative study of 19 patients with mammary tumors and 18 healthy volunteers, and, second, to determine the evolution of aminoacidemia after surgical tumor removal. Aminoacidemia was determined the day before (D0), and then five days, one month (M1), and six months after surgical removal of the tumor, and a single determination was performed in control subjects. Plasma levels (µmol L) of serine and glutamate were higher in cancer-bearing women at D0 (respectively, 124 ± 3 and 68 ± 7) than in healthy volunteers (respectively, 110 ± 6 and 48 ± 5). Surgical tumor removal induced a normalization of aminoacidemia (in µmol L at D5: serine: 114 ± 4; at M1: glutamate: 55 ± 6 Non Significant (NS) from values of healthy subjects). Among the various patterns reported for breast cancer, we confirm one of those described by Cascino in 1995, and we show that these levels revert to normal after tumor surgical removal. |
| doi_str_mv | 10.1081/CNV-120030208 |
| format | Article |
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The aim of this study was first to establish the specific modifications of plasma-free amino acid concentrations by a comparative study of 19 patients with mammary tumors and 18 healthy volunteers, and, second, to determine the evolution of aminoacidemia after surgical tumor removal. Aminoacidemia was determined the day before (D0), and then five days, one month (M1), and six months after surgical removal of the tumor, and a single determination was performed in control subjects. Plasma levels (µmol L) of serine and glutamate were higher in cancer-bearing women at D0 (respectively, 124 ± 3 and 68 ± 7) than in healthy volunteers (respectively, 110 ± 6 and 48 ± 5). Surgical tumor removal induced a normalization of aminoacidemia (in µmol L at D5: serine: 114 ± 4; at M1: glutamate: 55 ± 6 Non Significant (NS) from values of healthy subjects). Among the various patterns reported for breast cancer, we confirm one of those described by Cascino in 1995, and we show that these levels revert to normal after tumor surgical removal.</description><identifier>ISSN: 0735-7907</identifier><identifier>EISSN: 1532-4192</identifier><identifier>DOI: 10.1081/CNV-120030208</identifier><identifier>PMID: 15199602</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Aged ; Amino Acids - blood ; Amino Acids - metabolism ; Aminoacidemia ; Breast cancer ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Case-Control Studies ; Female ; Humans ; Middle Aged ; Post operative ; Preoperative ; Reference Values ; Time Factors</subject><ispartof>Cancer investigation, 2004, Vol.22 (2), p.203-210</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-5bc079a85811ad838c3e46f5d3320eadd98418c1d2ed0d711d2a1cc147d7524b3</citedby><cites>FETCH-LOGICAL-c386t-5bc079a85811ad838c3e46f5d3320eadd98418c1d2ed0d711d2a1cc147d7524b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1081/CNV-120030208$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1081/CNV-120030208$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15199602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minet-Quinard, Régine</creatorcontrib><creatorcontrib>Van Praagh, Isabelle</creatorcontrib><creatorcontrib>Kwiatkowski, Fabrice</creatorcontrib><creatorcontrib>Beaujon, Guy</creatorcontrib><creatorcontrib>Feillel, Viviane</creatorcontrib><creatorcontrib>Beaufrère, Bernard</creatorcontrib><creatorcontrib>Bargnoux, Pierre-Jean</creatorcontrib><creatorcontrib>Cynober, Luc</creatorcontrib><creatorcontrib>Vasson, Marie-Paule</creatorcontrib><title>Pre- and Postoperative Aminoacidemia in Breast Cancer: A Study vs. Matched Healthy Subjects</title><title>Cancer investigation</title><addtitle>Cancer Invest</addtitle><description>Various alterations of aminoacidemia have been described during breast cancer. The aim of this study was first to establish the specific modifications of plasma-free amino acid concentrations by a comparative study of 19 patients with mammary tumors and 18 healthy volunteers, and, second, to determine the evolution of aminoacidemia after surgical tumor removal. Aminoacidemia was determined the day before (D0), and then five days, one month (M1), and six months after surgical removal of the tumor, and a single determination was performed in control subjects. Plasma levels (µmol L) of serine and glutamate were higher in cancer-bearing women at D0 (respectively, 124 ± 3 and 68 ± 7) than in healthy volunteers (respectively, 110 ± 6 and 48 ± 5). Surgical tumor removal induced a normalization of aminoacidemia (in µmol L at D5: serine: 114 ± 4; at M1: glutamate: 55 ± 6 Non Significant (NS) from values of healthy subjects). Among the various patterns reported for breast cancer, we confirm one of those described by Cascino in 1995, and we show that these levels revert to normal after tumor surgical removal.</description><subject>Adult</subject><subject>Aged</subject><subject>Amino Acids - blood</subject><subject>Amino Acids - metabolism</subject><subject>Aminoacidemia</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Post operative</subject><subject>Preoperative</subject><subject>Reference Values</subject><subject>Time Factors</subject><issn>0735-7907</issn><issn>1532-4192</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFuEzEQQC0EomnhyBX5xG2Lx96NvdxCBBSpQKUCFw7WxJ5VHO2ug-0tyt-zJRGIQ08zhzdPo8fYCxCXIAy8Xn_-XoEUQgkpzCO2gEbJqoZWPmYLoVVT6VboM3ae804IMFI3T9kZNNC2SyEX7MdNoorj6PlNzCXuKWEJd8RXQxgjuuBpCMjDyN8mwlz4GkdH6Q1f8dsy-QO_y5f8Exa3Jc-vCPuyPfDbabMjV_Iz9qTDPtPz07xg396_-7q-qq6_fPi4Xl1XTpllqZqNE7pF0xgA9EYZp6hedo1XSgpC71tTg3HgJXnhNcwLgnNQa68bWW_UBXt19O5T_DlRLnYI2VHf40hxylZLIWetnMHqCLoUc07U2X0KA6aDBWHva9q5pv1bc-ZfnsTTZiD_jz7lmwFzBMLYxTTgr5h6bwse-pi6NKcK2aqH3Pq_0-2feA4T2V2c0jgHe-Cr37hUkx0</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>Minet-Quinard, Régine</creator><creator>Van Praagh, Isabelle</creator><creator>Kwiatkowski, Fabrice</creator><creator>Beaujon, Guy</creator><creator>Feillel, Viviane</creator><creator>Beaufrère, Bernard</creator><creator>Bargnoux, Pierre-Jean</creator><creator>Cynober, Luc</creator><creator>Vasson, Marie-Paule</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2004</creationdate><title>Pre- and Postoperative Aminoacidemia in Breast Cancer: A Study vs. Matched Healthy Subjects</title><author>Minet-Quinard, Régine ; Van Praagh, Isabelle ; Kwiatkowski, Fabrice ; Beaujon, Guy ; Feillel, Viviane ; Beaufrère, Bernard ; Bargnoux, Pierre-Jean ; Cynober, Luc ; Vasson, Marie-Paule</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-5bc079a85811ad838c3e46f5d3320eadd98418c1d2ed0d711d2a1cc147d7524b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amino Acids - blood</topic><topic>Amino Acids - metabolism</topic><topic>Aminoacidemia</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Post operative</topic><topic>Preoperative</topic><topic>Reference Values</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Minet-Quinard, Régine</creatorcontrib><creatorcontrib>Van Praagh, Isabelle</creatorcontrib><creatorcontrib>Kwiatkowski, Fabrice</creatorcontrib><creatorcontrib>Beaujon, Guy</creatorcontrib><creatorcontrib>Feillel, Viviane</creatorcontrib><creatorcontrib>Beaufrère, Bernard</creatorcontrib><creatorcontrib>Bargnoux, Pierre-Jean</creatorcontrib><creatorcontrib>Cynober, Luc</creatorcontrib><creatorcontrib>Vasson, Marie-Paule</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Minet-Quinard, Régine</au><au>Van Praagh, Isabelle</au><au>Kwiatkowski, Fabrice</au><au>Beaujon, Guy</au><au>Feillel, Viviane</au><au>Beaufrère, Bernard</au><au>Bargnoux, Pierre-Jean</au><au>Cynober, Luc</au><au>Vasson, Marie-Paule</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pre- and Postoperative Aminoacidemia in Breast Cancer: A Study vs. Matched Healthy Subjects</atitle><jtitle>Cancer investigation</jtitle><addtitle>Cancer Invest</addtitle><date>2004</date><risdate>2004</risdate><volume>22</volume><issue>2</issue><spage>203</spage><epage>210</epage><pages>203-210</pages><issn>0735-7907</issn><eissn>1532-4192</eissn><abstract>Various alterations of aminoacidemia have been described during breast cancer. The aim of this study was first to establish the specific modifications of plasma-free amino acid concentrations by a comparative study of 19 patients with mammary tumors and 18 healthy volunteers, and, second, to determine the evolution of aminoacidemia after surgical tumor removal. Aminoacidemia was determined the day before (D0), and then five days, one month (M1), and six months after surgical removal of the tumor, and a single determination was performed in control subjects. Plasma levels (µmol L) of serine and glutamate were higher in cancer-bearing women at D0 (respectively, 124 ± 3 and 68 ± 7) than in healthy volunteers (respectively, 110 ± 6 and 48 ± 5). Surgical tumor removal induced a normalization of aminoacidemia (in µmol L at D5: serine: 114 ± 4; at M1: glutamate: 55 ± 6 Non Significant (NS) from values of healthy subjects). Among the various patterns reported for breast cancer, we confirm one of those described by Cascino in 1995, and we show that these levels revert to normal after tumor surgical removal.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>15199602</pmid><doi>10.1081/CNV-120030208</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Amino Acids - blood Amino Acids - metabolism Aminoacidemia Breast cancer Breast Neoplasms - pathology Breast Neoplasms - surgery Case-Control Studies Female Humans Middle Aged Post operative Preoperative Reference Values Time Factors |
| title | Pre- and Postoperative Aminoacidemia in Breast Cancer: A Study vs. Matched Healthy Subjects |
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