ZNF768: controlling cellular senescence and proliferation with ten fingers
We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senescence, while its overexpression allows cells to bypa...
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| Veröffentlicht in: | Molecular & cellular oncology 2021-11, Vol.8 (6), p.1985930-1985930 |
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| container_end_page | 1985930 |
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| container_issue | 6 |
| container_start_page | 1985930 |
| container_title | Molecular & cellular oncology |
| container_volume | 8 |
| creator | Villot, Romain Poirier, Audrey Devillers, Romain Kolnoguz, Aliona Elowe, Sabine Manem, Venkata S. K. Joubert, Philippe Mallette, Frédérick A. Laplante, Mathieu |
| description | We recently identified Zinc-finger protein 768 (ZNF768) as a novel transcription factor controlling cell fate decision downstream of Rat sarcoma virus (RAS). We showed that ZNF768 depletion impairs cell cycle progression and triggers cellular senescence, while its overexpression allows cells to bypass oncogene-induced senescence. Elevated ZNF768 levels is common in tumors, suggesting that ZNF768 may help to escape cellular senescence, sustain proliferation and promote malignant transformation. Here, we discuss these recent findings and highlight key questions emerging from our work. |
| doi_str_mv | 10.1080/23723556.2021.1985930 |
| format | Article |
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| title | ZNF768: controlling cellular senescence and proliferation with ten fingers |
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