Collapse of redox homeostasis during aging and stress

Collapse of redox homeostasis during aging and stress

Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Molecular & cellular oncology 2016-03, Vol.3 (2), p.e1091060-e1091060
Hauptverfasser: Feleciano, Diogo R., Kirstein, Janine
Format: Artikel
Sprache:eng
Schlagworte:
Author's View
Chaperones
C.elegans
ER
proteostasis
redox homeostasis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page e1091060
container_issue 2
container_start_page e1091060
container_title Molecular & cellular oncology
container_volume 3
creator Feleciano, Diogo R.
Kirstein, Janine
description Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and during aging.
doi_str_mv 10.1080/23723556.2015.1091060
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1080_23723556_2015_1091060</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1797874385</sourcerecordid><originalsourceid>FETCH-LOGICAL-c468t-8de51bc955caa29a7556967b0222127e114d3f5580399ce180117a9e58129aa23</originalsourceid><addsrcrecordid>eNp9kE1PwzAMhiMEYtPYTwD1yKUjTpomuSDQxJc0iQuco6xNt6C2GUkH7N-Tsg2NCxfHsh-_dl6EzgFPAAt8RSgnlLF8QjCwWJKAc3yEhn097RvHB_kAjUN4wziiRBBgp2hAOMUiBzJEbOrqWq-CSVyVeFO6r2TpGuNCp4MNSbn2tl0kevET2zIJnTchnKGTStfBjHfvCL3e371MH9PZ88PT9HaWFlkuulSUhsG8kIwVWhOpebxG5nyOCSFAuAHISloxJjCVsjAgMADX0jABkdaEjtD1Vne1njemLEzbeV2rlbeN9hvltFV_O61dqoX7UJnEjEoRBS53At69r03oVGNDYeKXW-PWQQGXXPCMChZRtkUL70LwpvpdA1j1rqu966p3Xe1cj3MXhzf-Tu09jsDNFrBt5XyjP52vS9XpTe185XVb2KDo_zu-AZH5kBs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1797874385</pqid></control><display><type>article</type><title>Collapse of redox homeostasis during aging and stress</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Feleciano, Diogo R. ; Kirstein, Janine</creator><creatorcontrib>Feleciano, Diogo R. ; Kirstein, Janine</creatorcontrib><description>Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and during aging.</description><identifier>ISSN: 2372-3556</identifier><identifier>ISSN: 2372-3548</identifier><identifier>EISSN: 2372-3556</identifier><identifier>DOI: 10.1080/23723556.2015.1091060</identifier><identifier>PMID: 27308612</identifier><language>eng</language><publisher>United States: Taylor &amp; Francis</publisher><subject>Author's View ; Chaperones; C.elegans; ER; proteostasis; redox homeostasis</subject><ispartof>Molecular &amp; cellular oncology, 2016-03, Vol.3 (2), p.e1091060-e1091060</ispartof><rights>2016 Taylor &amp; Francis Group, LLC 2016</rights><rights>2016 Taylor &amp; Francis Group, LLC 2016 Taylor &amp; Francis Group, LLC</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-8de51bc955caa29a7556967b0222127e114d3f5580399ce180117a9e58129aa23</citedby><cites>FETCH-LOGICAL-c468t-8de51bc955caa29a7556967b0222127e114d3f5580399ce180117a9e58129aa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905398/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905398/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27308612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feleciano, Diogo R.</creatorcontrib><creatorcontrib>Kirstein, Janine</creatorcontrib><title>Collapse of redox homeostasis during aging and stress</title><title>Molecular &amp; cellular oncology</title><addtitle>Mol Cell Oncol</addtitle><description>Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and during aging.</description><subject>Author's View</subject><subject>Chaperones; C.elegans; ER; proteostasis; redox homeostasis</subject><issn>2372-3556</issn><issn>2372-3548</issn><issn>2372-3556</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhiMEYtPYTwD1yKUjTpomuSDQxJc0iQuco6xNt6C2GUkH7N-Tsg2NCxfHsh-_dl6EzgFPAAt8RSgnlLF8QjCwWJKAc3yEhn097RvHB_kAjUN4wziiRBBgp2hAOMUiBzJEbOrqWq-CSVyVeFO6r2TpGuNCp4MNSbn2tl0kevET2zIJnTchnKGTStfBjHfvCL3e371MH9PZ88PT9HaWFlkuulSUhsG8kIwVWhOpebxG5nyOCSFAuAHISloxJjCVsjAgMADX0jABkdaEjtD1Vne1njemLEzbeV2rlbeN9hvltFV_O61dqoX7UJnEjEoRBS53At69r03oVGNDYeKXW-PWQQGXXPCMChZRtkUL70LwpvpdA1j1rqu966p3Xe1cj3MXhzf-Tu09jsDNFrBt5XyjP52vS9XpTe185XVb2KDo_zu-AZH5kBs</recordid><startdate>20160303</startdate><enddate>20160303</enddate><creator>Feleciano, Diogo R.</creator><creator>Kirstein, Janine</creator><general>Taylor &amp; Francis</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160303</creationdate><title>Collapse of redox homeostasis during aging and stress</title><author>Feleciano, Diogo R. ; Kirstein, Janine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-8de51bc955caa29a7556967b0222127e114d3f5580399ce180117a9e58129aa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Author's View</topic><topic>Chaperones; C.elegans; ER; proteostasis; redox homeostasis</topic><toplevel>online_resources</toplevel><creatorcontrib>Feleciano, Diogo R.</creatorcontrib><creatorcontrib>Kirstein, Janine</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecular &amp; cellular oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feleciano, Diogo R.</au><au>Kirstein, Janine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collapse of redox homeostasis during aging and stress</atitle><jtitle>Molecular &amp; cellular oncology</jtitle><addtitle>Mol Cell Oncol</addtitle><date>2016-03-03</date><risdate>2016</risdate><volume>3</volume><issue>2</issue><spage>e1091060</spage><epage>e1091060</epage><pages>e1091060-e1091060</pages><issn>2372-3556</issn><issn>2372-3548</issn><eissn>2372-3556</eissn><abstract>Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and during aging.</abstract><cop>United States</cop><pub>Taylor &amp; Francis</pub><pmid>27308612</pmid><doi>10.1080/23723556.2015.1091060</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2372-3556
ispartof Molecular & cellular oncology, 2016-03, Vol.3 (2), p.e1091060-e1091060
issn 2372-3556
2372-3548
2372-3556
language eng
recordid cdi_crossref_primary_10_1080_23723556_2015_1091060
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central
subjects Author's View
Chaperones
C.elegans
ER
proteostasis
redox homeostasis
title Collapse of redox homeostasis during aging and stress
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T00%3A04%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Collapse%20of%20redox%20homeostasis%20during%20aging%20and%20stress&rft.jtitle=Molecular%20&%20cellular%20oncology&rft.au=Feleciano,%20Diogo%20R.&rft.date=2016-03-03&rft.volume=3&rft.issue=2&rft.spage=e1091060&rft.epage=e1091060&rft.pages=e1091060-e1091060&rft.issn=2372-3556&rft.eissn=2372-3556&rft_id=info:doi/10.1080/23723556.2015.1091060&rft_dat=%3Cproquest_cross%3E1797874385%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1797874385&rft_id=info:pmid/27308612&rfr_iscdi=true