Collapse of redox homeostasis during aging and stress

Collapse of redox homeostasis during aging and stress

Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and...

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Veröffentlicht in:Molecular & cellular oncology 2016-03, Vol.3 (2), p.e1091060-e1091060
Hauptverfasser: Feleciano, Diogo R., Kirstein, Janine
Format: Artikel
Sprache:eng
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Chaperones
C.elegans
ER
proteostasis
redox homeostasis
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Beschreibung
Zusammenfassung:Coordination of the protein homeostasis network and redox states in eukaryotic cells is crucial for cellular and organismal fitness. By employing endogenous in vivo redox sensors we demonstrate that the redox state of the ER and cytosol is subject to profound changes upon proteotoxic challenges and during aging.
ISSN:2372-3556
2372-3548
2372-3556
DOI:10.1080/23723556.2015.1091060