Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells)
The extensive relevance of nanoparticles arouses the requirement for manufacturing although the predictable technique are frequently perilous and energy saving. In the current study, zinc oxide nanoparticles manufactured from Allium cepa avert UVB radiation interceded irritation in human epidermal k...
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| creator | Wu, Fenglian Chen, Yanxin Li, Guoliang Zhu, Donglai Wang, Lianying Wang, Jiaxin |
| description | The extensive relevance of nanoparticles arouses the requirement for manufacturing although the predictable technique are frequently perilous and energy saving. In the current study, zinc oxide nanoparticles manufactured from Allium cepa avert UVB radiation interceded irritation in human epidermal keratinocytes (HaCaT cells). In the current study, the zinc oxide nanoparticles (ZnO-NPs) was synthesized from the extract of A. cepa. The optimized ZnO-NPs hence attained and was enumerated and exemplified by UV visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscope (SEM) and EDAX impending analysis. In addition, amalgamated ZnO-NPs were experienced for cell viability (MTT), formation of reactive oxygen species (ROS), apoptosis, and antioxidant and lipid peroxidation (TBARS) levels. Also, we explored the effect of A. cepa ZnO-NPs in molecular level by evaluating the inflammatory and apoptotic markers, in which ZnO-NPs reinstated the interleukins 6, 10 and related signaling molecules like iNOS, COX-2 levels. Ultimately, ZnO-NPs induce apoptotic markers (Bax, Bcl-2) and also recommended that ZnO-NPs might aggravate cancer cell apoptosis in HaCaT cells. |
| doi_str_mv | 10.1080/21691401.2019.1642905 |
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In the current study, zinc oxide nanoparticles manufactured from Allium cepa avert UVB radiation interceded irritation in human epidermal keratinocytes (HaCaT cells). In the current study, the zinc oxide nanoparticles (ZnO-NPs) was synthesized from the extract of A. cepa. The optimized ZnO-NPs hence attained and was enumerated and exemplified by UV visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscope (SEM) and EDAX impending analysis. In addition, amalgamated ZnO-NPs were experienced for cell viability (MTT), formation of reactive oxygen species (ROS), apoptosis, and antioxidant and lipid peroxidation (TBARS) levels. Also, we explored the effect of A. cepa ZnO-NPs in molecular level by evaluating the inflammatory and apoptotic markers, in which ZnO-NPs reinstated the interleukins 6, 10 and related signaling molecules like iNOS, COX-2 levels. Ultimately, ZnO-NPs induce apoptotic markers (Bax, Bcl-2) and also recommended that ZnO-NPs might aggravate cancer cell apoptosis in HaCaT cells.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.1080/21691401.2019.1642905</identifier><identifier>PMID: 31456420</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Allium cepa ; Animals ; Antioxidants ; Apoptosis ; Bcl-2 protein ; Cell Line ; Cell viability ; Cyclooxygenase-2 ; Energy conservation ; Epidermis - metabolism ; Fourier analysis ; Fourier transforms ; HaCaT cells: Allium cepa ; Humans ; Inflammation ; Inflammation - etiology ; Inflammation - metabolism ; Inflammation - pathology ; Inflammation - prevention & control ; Infrared spectroscopy ; Interleukins ; Intracellular Space - drug effects ; Intracellular Space - metabolism ; Intracellular Space - radiation effects ; Irritation ; Keratinocytes ; Keratinocytes - cytology ; Keratinocytes - drug effects ; Keratinocytes - metabolism ; Keratinocytes - radiation effects ; Levels ; Lipid peroxidation ; Lipids ; Markers ; Membrane Potential, Mitochondrial - drug effects ; Nanoparticles ; Nitric-oxide synthase ; Onions - metabolism ; Radiation-Protective Agents - chemistry ; Radiation-Protective Agents - metabolism ; Radiation-Protective Agents - pharmacology ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Scanning electron microscopy ; Spectrum analysis ; Synthesis ; Thiobarbituric Acid Reactive Substances - metabolism ; Transmission electron microscopy ; Ultraviolet radiation ; Ultraviolet Rays - adverse effects ; X-ray diffraction ; Zinc oxide ; Zinc Oxide - chemistry ; Zinc Oxide - metabolism ; Zinc Oxide - pharmacology ; Zinc oxide nanoparticles ; Zinc oxides</subject><ispartof>Artificial cells, nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.3548-3558</ispartof><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group 2019</rights><rights>2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-fba29c422c3f07cb4124f039ae25dfb2e6f1ed2cf7a5e0b121772b960d2684f03</citedby><cites>FETCH-LOGICAL-c507t-fba29c422c3f07cb4124f039ae25dfb2e6f1ed2cf7a5e0b121772b960d2684f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,2096,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31456420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Fenglian</creatorcontrib><creatorcontrib>Chen, Yanxin</creatorcontrib><creatorcontrib>Li, Guoliang</creatorcontrib><creatorcontrib>Zhu, Donglai</creatorcontrib><creatorcontrib>Wang, Lianying</creatorcontrib><creatorcontrib>Wang, Jiaxin</creatorcontrib><title>Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells)</title><title>Artificial cells, nanomedicine, and biotechnology</title><addtitle>Artif Cells Nanomed Biotechnol</addtitle><description>The extensive relevance of nanoparticles arouses the requirement for manufacturing although the predictable technique are frequently perilous and energy saving. In the current study, zinc oxide nanoparticles manufactured from Allium cepa avert UVB radiation interceded irritation in human epidermal keratinocytes (HaCaT cells). In the current study, the zinc oxide nanoparticles (ZnO-NPs) was synthesized from the extract of A. cepa. The optimized ZnO-NPs hence attained and was enumerated and exemplified by UV visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscope (SEM) and EDAX impending analysis. In addition, amalgamated ZnO-NPs were experienced for cell viability (MTT), formation of reactive oxygen species (ROS), apoptosis, and antioxidant and lipid peroxidation (TBARS) levels. Also, we explored the effect of A. cepa ZnO-NPs in molecular level by evaluating the inflammatory and apoptotic markers, in which ZnO-NPs reinstated the interleukins 6, 10 and related signaling molecules like iNOS, COX-2 levels. Ultimately, ZnO-NPs induce apoptotic markers (Bax, Bcl-2) and also recommended that ZnO-NPs might aggravate cancer cell apoptosis in HaCaT cells.</description><subject>Allium cepa</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Bcl-2 protein</subject><subject>Cell Line</subject><subject>Cell viability</subject><subject>Cyclooxygenase-2</subject><subject>Energy conservation</subject><subject>Epidermis - metabolism</subject><subject>Fourier analysis</subject><subject>Fourier transforms</subject><subject>HaCaT cells: Allium cepa</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - etiology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Inflammation - prevention & control</subject><subject>Infrared spectroscopy</subject><subject>Interleukins</subject><subject>Intracellular Space - drug effects</subject><subject>Intracellular Space - metabolism</subject><subject>Intracellular Space - radiation effects</subject><subject>Irritation</subject><subject>Keratinocytes</subject><subject>Keratinocytes - cytology</subject><subject>Keratinocytes - drug effects</subject><subject>Keratinocytes - metabolism</subject><subject>Keratinocytes - radiation effects</subject><subject>Levels</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Markers</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Nanoparticles</subject><subject>Nitric-oxide synthase</subject><subject>Onions - metabolism</subject><subject>Radiation-Protective Agents - chemistry</subject><subject>Radiation-Protective Agents - metabolism</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Synthesis</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Transmission electron microscopy</subject><subject>Ultraviolet radiation</subject><subject>Ultraviolet Rays - adverse effects</subject><subject>X-ray diffraction</subject><subject>Zinc oxide</subject><subject>Zinc Oxide - chemistry</subject><subject>Zinc Oxide - metabolism</subject><subject>Zinc Oxide - pharmacology</subject><subject>Zinc oxide nanoparticles</subject><subject>Zinc oxides</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9Uk1v1DAQjRCIVqU_AWSJSzls8TjO1412BbRSJS4tQlysiTOmXhI72Amw_Av-MQ673QMHfLE1fvOex-9l2XPg58Br_lpA2YDkcC44NOdQStHw4lF2vNRXIOHT48OZw1F2GuOGp1VDWRXyaXaUgyxSEz_Ofn-2TjP_03bEHDo_Ypis7imyuHXTPUX7izpmgh_YRd_beWCaRmRjoO_kpsjuPl6ygJ3FyXrHBlpOqcE60-Mw7KrWsft5QMdoTDJhwJ59pZDunNfbKUmdXeEabxNz38dXz7InBvtIp_v9JLt79_Z2fbW6-fD-en1xs9IFr6aVaVE0Wgqhc8Mr3UoQ0vC8QRJFZ1pBpQHqhDYVFsRbEFBVom1K3omyXpAn2fWOt_O4UWOwA4at8mjV34IPX9T-LxRyWUtNBZRJBHjbQEG5gFa3JGsOdeI623GNwX-bKU5qsHEZBx35OSohaqhlXQpI0Jf_QDd-Di5NqkReiLxuyiZPqGKH0sHHGMgcHghcLRFQDxFQSwTUPgKp78WefW6TGYeuB8MT4M0OkBzyyYofPvSdmnDb-2ACOm1jAv9X4w-0GMB5</recordid><startdate>201912</startdate><enddate>201912</enddate><creator>Wu, Fenglian</creator><creator>Chen, Yanxin</creator><creator>Li, Guoliang</creator><creator>Zhu, Donglai</creator><creator>Wang, Lianying</creator><creator>Wang, Jiaxin</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>201912</creationdate><title>Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells)</title><author>Wu, Fenglian ; Chen, Yanxin ; Li, Guoliang ; Zhu, Donglai ; Wang, Lianying ; Wang, Jiaxin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-fba29c422c3f07cb4124f039ae25dfb2e6f1ed2cf7a5e0b121772b960d2684f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Allium cepa</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Apoptosis</topic><topic>Bcl-2 protein</topic><topic>Cell Line</topic><topic>Cell viability</topic><topic>Cyclooxygenase-2</topic><topic>Energy conservation</topic><topic>Epidermis - metabolism</topic><topic>Fourier analysis</topic><topic>Fourier transforms</topic><topic>HaCaT cells: Allium cepa</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - etiology</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Inflammation - prevention & control</topic><topic>Infrared spectroscopy</topic><topic>Interleukins</topic><topic>Intracellular Space - drug effects</topic><topic>Intracellular Space - metabolism</topic><topic>Intracellular Space - radiation effects</topic><topic>Irritation</topic><topic>Keratinocytes</topic><topic>Keratinocytes - cytology</topic><topic>Keratinocytes - drug effects</topic><topic>Keratinocytes - metabolism</topic><topic>Keratinocytes - radiation effects</topic><topic>Levels</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Markers</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Nanoparticles</topic><topic>Nitric-oxide synthase</topic><topic>Onions - metabolism</topic><topic>Radiation-Protective Agents - chemistry</topic><topic>Radiation-Protective Agents - metabolism</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Scanning electron microscopy</topic><topic>Spectrum analysis</topic><topic>Synthesis</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Transmission electron microscopy</topic><topic>Ultraviolet radiation</topic><topic>Ultraviolet Rays - adverse effects</topic><topic>X-ray diffraction</topic><topic>Zinc oxide</topic><topic>Zinc Oxide - chemistry</topic><topic>Zinc Oxide - metabolism</topic><topic>Zinc Oxide - pharmacology</topic><topic>Zinc oxide nanoparticles</topic><topic>Zinc oxides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Fenglian</creatorcontrib><creatorcontrib>Chen, Yanxin</creatorcontrib><creatorcontrib>Li, Guoliang</creatorcontrib><creatorcontrib>Zhu, Donglai</creatorcontrib><creatorcontrib>Wang, Lianying</creatorcontrib><creatorcontrib>Wang, Jiaxin</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Fenglian</au><au>Chen, Yanxin</au><au>Li, Guoliang</au><au>Zhu, Donglai</au><au>Wang, Lianying</au><au>Wang, Jiaxin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells)</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2019-12</date><risdate>2019</risdate><volume>47</volume><issue>1</issue><spage>3548</spage><epage>3558</epage><pages>3548-3558</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>The extensive relevance of nanoparticles arouses the requirement for manufacturing although the predictable technique are frequently perilous and energy saving. In the current study, zinc oxide nanoparticles manufactured from Allium cepa avert UVB radiation interceded irritation in human epidermal keratinocytes (HaCaT cells). In the current study, the zinc oxide nanoparticles (ZnO-NPs) was synthesized from the extract of A. cepa. The optimized ZnO-NPs hence attained and was enumerated and exemplified by UV visible spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), scanning electron microscope (SEM) and EDAX impending analysis. In addition, amalgamated ZnO-NPs were experienced for cell viability (MTT), formation of reactive oxygen species (ROS), apoptosis, and antioxidant and lipid peroxidation (TBARS) levels. Also, we explored the effect of A. cepa ZnO-NPs in molecular level by evaluating the inflammatory and apoptotic markers, in which ZnO-NPs reinstated the interleukins 6, 10 and related signaling molecules like iNOS, COX-2 levels. Ultimately, ZnO-NPs induce apoptotic markers (Bax, Bcl-2) and also recommended that ZnO-NPs might aggravate cancer cell apoptosis in HaCaT cells.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>31456420</pmid><doi>10.1080/21691401.2019.1642905</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Allium cepa Animals Antioxidants Apoptosis Bcl-2 protein Cell Line Cell viability Cyclooxygenase-2 Energy conservation Epidermis - metabolism Fourier analysis Fourier transforms HaCaT cells: Allium cepa Humans Inflammation Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Infrared spectroscopy Interleukins Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - radiation effects Irritation Keratinocytes Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - radiation effects Levels Lipid peroxidation Lipids Markers Membrane Potential, Mitochondrial - drug effects Nanoparticles Nitric-oxide synthase Onions - metabolism Radiation-Protective Agents - chemistry Radiation-Protective Agents - metabolism Radiation-Protective Agents - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Scanning electron microscopy Spectrum analysis Synthesis Thiobarbituric Acid Reactive Substances - metabolism Transmission electron microscopy Ultraviolet radiation Ultraviolet Rays - adverse effects X-ray diffraction Zinc oxide Zinc Oxide - chemistry Zinc Oxide - metabolism Zinc Oxide - pharmacology Zinc oxide nanoparticles Zinc oxides |
| title | Zinc oxide nanoparticles synthesized from Allium cepa prevents UVB radiation mediated inflammation in human epidermal keratinocytes (HaCaT cells) |
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