HBs antigen and mannose loading on the surface of iron oxide nanoparticles in order to immuno-targeting: fabrication, characterization, cellular and humoral immunoassay

Mannosylation of nanovaccine is an appropriate strategy for targeting the mannose receptors on DCs. Here, HBsAg and mannose loaded on the surface of iron oxide nanoparticles to increases HBsAg vaccine potency. Nanoparticles are made by co-precipitation method and bonded to the HBsAg and mannose by c...

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Veröffentlicht in:	Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2019-12, Vol.47 (1), p.1543-1558
Hauptverfasser:	Rezaei, Mahsa, Hosseini, Seyed Nezamedin, Khavari-Nejad, Ramazan Ali, Najafi, Farhood, Mahdavi, Mehdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigenicity Antigens Cell Proliferation - drug effects Cell Survival - drug effects Chemical bonds Cytokines Cytokines - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Drug Carriers - chemistry Drug Carriers - toxicity Female Ferric Compounds - chemistry Gene expression HEK293 Cells Hepatitis B surface antigen Hepatitis B Surface Antigens - chemistry Hepatitis B Surface Antigens - pharmacology Humans immune responses Immunity, Cellular - drug effects Immunity, Humoral - drug effects Immunization immuno-targeting Immunoassay Immunoglobulin G Immunoglobulin G - metabolism Interleukin 12 Interleukin 2 Interleukin 4 Interleukin 6 Iron oxide nanoparticle Iron oxides Lymphocytes Lymphocytes - cytology Lymphocytes - drug effects Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mannose Mannose - chemistry Mannose receptors Mice Mice, Inbred BALB C Nanoparticles Organic chemistry Physicochemical properties Receptors Structural integrity Toxicity Tumor necrosis factor-α Vaccines Vaccines - chemistry Vaccines - pharmacology Zeta potential γ-Interferon
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