Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells
Radiotherapy is one of the most widely used treatments for therapy of malignant tumors, but resistance to radiation of hypoxic cells in tumor tissues is still a serious concern. Previous studies have demonstrated that silver nanoparticles (AgNPs) enhance the radiosensitivity of human glioma cells in...
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| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2018-01, Vol.46 (S3), p.922-930 |
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| creator | Liu, Zhujun Tan, Hongye Zhang, Xiaohong Chen, Feng Zhou, Zhuo Hu, Xiaodan Chang, Shuquan Liu, Peidang Zhang, Haiqian |
| description | Radiotherapy is one of the most widely used treatments for therapy of malignant tumors, but resistance to radiation of hypoxic cells in tumor tissues is still a serious concern. Previous studies have demonstrated that silver nanoparticles (AgNPs) enhance the radiosensitivity of human glioma cells in vitro, but the effect of AgNPs on hypoxic glioma cells has not been investigated in detail. The main purpose of this study is to evaluate the radiosensitizing efficacy of AgNPs on hypoxic glioma cells. The half maximal inhibitory concentration (IC50) values of AgNPs for the hypoxic U251 cells and C6 cells were 30.32 μg/mL and 27.53 μg/mL, respectively. The sensitization enhancement ratio (SER) demonstrated that AgNPs exhibit higher capacity in radiosensitization in hypoxic cells (U251: 1.78; C6: 1.84) than that in normoxic cells (U251: 1.34; C6: 1.45). The underlying mechanism of AgNPs' radiosensitization in hypoxic cells is through the promotion of apoptosis and enhanced destructive autophagy. There is evidence of crosstalk between apoptosis and autophagy in AgNPs-radiosensitized hypoxic cells where inhibition of autophagy results in decreased apoptosis. These findings suggest that AgNPs can be used as a highly effective nano-radiosensitizer for the treatment of hypoxic glioma. |
| doi_str_mv | 10.1080/21691401.2018.1518912 |
| format | Article |
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Previous studies have demonstrated that silver nanoparticles (AgNPs) enhance the radiosensitivity of human glioma cells in vitro, but the effect of AgNPs on hypoxic glioma cells has not been investigated in detail. The main purpose of this study is to evaluate the radiosensitizing efficacy of AgNPs on hypoxic glioma cells. The half maximal inhibitory concentration (IC50) values of AgNPs for the hypoxic U251 cells and C6 cells were 30.32 μg/mL and 27.53 μg/mL, respectively. The sensitization enhancement ratio (SER) demonstrated that AgNPs exhibit higher capacity in radiosensitization in hypoxic cells (U251: 1.78; C6: 1.84) than that in normoxic cells (U251: 1.34; C6: 1.45). The underlying mechanism of AgNPs' radiosensitization in hypoxic cells is through the promotion of apoptosis and enhanced destructive autophagy. There is evidence of crosstalk between apoptosis and autophagy in AgNPs-radiosensitized hypoxic cells where inhibition of autophagy results in decreased apoptosis. These findings suggest that AgNPs can be used as a highly effective nano-radiosensitizer for the treatment of hypoxic glioma.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.1080/21691401.2018.1518912</identifier><identifier>PMID: 30307330</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Apoptosis ; Autophagy ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Brain Neoplasms - radiotherapy ; Brain tumors ; Cell Hypoxia - drug effects ; Cell Hypoxia - radiation effects ; Cell Line, Tumor ; Cell Survival - drug effects ; Cell Survival - radiation effects ; Crosstalk ; Glioma - metabolism ; Glioma - pathology ; Glioma - radiotherapy ; Glioma cells ; Humans ; Hypoxia ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - therapeutic use ; Nanoparticles ; Phagocytosis ; Radiation therapy ; Radiation tolerance ; Radiation-Sensitizing Agents - chemistry ; Radiation-Sensitizing Agents - pharmacology ; Radiosensitivity ; Radiosensitization ; Radiotherapy ; Silver ; Silver - chemistry ; Silver - pharmacology ; silver nanoparticles ; Tumors ; X-Rays</subject><ispartof>Artificial cells, nanomedicine, and biotechnology, 2018-01, Vol.46 (S3), p.922-930</ispartof><rights>2018 Informa UK Limited, trading as Taylor & Francis Group 2018</rights><rights>2018 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-23fedbd572e7bc1658f9a08b4d5f4614202dd9243ef2594071092f799416a6e23</citedby><cites>FETCH-LOGICAL-c507t-23fedbd572e7bc1658f9a08b4d5f4614202dd9243ef2594071092f799416a6e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30307330$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Zhujun</creatorcontrib><creatorcontrib>Tan, Hongye</creatorcontrib><creatorcontrib>Zhang, Xiaohong</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Zhou, Zhuo</creatorcontrib><creatorcontrib>Hu, Xiaodan</creatorcontrib><creatorcontrib>Chang, Shuquan</creatorcontrib><creatorcontrib>Liu, Peidang</creatorcontrib><creatorcontrib>Zhang, Haiqian</creatorcontrib><title>Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells</title><title>Artificial cells, nanomedicine, and biotechnology</title><addtitle>Artif Cells Nanomed Biotechnol</addtitle><description>Radiotherapy is one of the most widely used treatments for therapy of malignant tumors, but resistance to radiation of hypoxic cells in tumor tissues is still a serious concern. Previous studies have demonstrated that silver nanoparticles (AgNPs) enhance the radiosensitivity of human glioma cells in vitro, but the effect of AgNPs on hypoxic glioma cells has not been investigated in detail. The main purpose of this study is to evaluate the radiosensitizing efficacy of AgNPs on hypoxic glioma cells. The half maximal inhibitory concentration (IC50) values of AgNPs for the hypoxic U251 cells and C6 cells were 30.32 μg/mL and 27.53 μg/mL, respectively. The sensitization enhancement ratio (SER) demonstrated that AgNPs exhibit higher capacity in radiosensitization in hypoxic cells (U251: 1.78; C6: 1.84) than that in normoxic cells (U251: 1.34; C6: 1.45). The underlying mechanism of AgNPs' radiosensitization in hypoxic cells is through the promotion of apoptosis and enhanced destructive autophagy. There is evidence of crosstalk between apoptosis and autophagy in AgNPs-radiosensitized hypoxic cells where inhibition of autophagy results in decreased apoptosis. These findings suggest that AgNPs can be used as a highly effective nano-radiosensitizer for the treatment of hypoxic glioma.</description><subject>Apoptosis</subject><subject>Autophagy</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain tumors</subject><subject>Cell Hypoxia - drug effects</subject><subject>Cell Hypoxia - radiation effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Cell Survival - radiation effects</subject><subject>Crosstalk</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Glioma - radiotherapy</subject><subject>Glioma cells</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Nanoparticles</subject><subject>Phagocytosis</subject><subject>Radiation therapy</subject><subject>Radiation tolerance</subject><subject>Radiation-Sensitizing Agents - chemistry</subject><subject>Radiation-Sensitizing Agents - pharmacology</subject><subject>Radiosensitivity</subject><subject>Radiosensitization</subject><subject>Radiotherapy</subject><subject>Silver</subject><subject>Silver - chemistry</subject><subject>Silver - pharmacology</subject><subject>silver nanoparticles</subject><subject>Tumors</subject><subject>X-Rays</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9vFCEUx4nR2Kb2T9CQePGyK48fA9w0TbVNmnipiTfCMODSzMAIs9b572Wz2x48yAXy8nnvffMBobdAtkAU-Uih08AJbCkBtQUBSgN9gc4P9Q1w-PHy-U3gDF3W-kDaUdBJwV-jM0YYkYyRc3R_nXY2OT_5tOAccLFDzMvOFzuv2IcQnXUr7ldc4_jbF5xsyrMtS3SjrzgmvFvn_Cc6_HOMebLY-XGsb9CrYMfqL0_3Bfr-5fr-6mZz9-3r7dXnu40TRC4byoIf-kFI6mXvoBMqaEtUzwcReAecEjoMmnLmAxWaEwlE0yC15tDZzlN2gT4c584l_9r7upgp1kMCm3zeV0MBFCNKctHQ9_-gD3lfUkvXKCUbqHTXKHGkXMm1Fh_MXOJky2qAmIN582TeHMybk_nW9-40fd9PfnjuevLcgE9HIKaQy2QfcxkHs9h1zCWU9gGxGvb_HX8BsViQ8Q</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Liu, Zhujun</creator><creator>Tan, Hongye</creator><creator>Zhang, Xiaohong</creator><creator>Chen, Feng</creator><creator>Zhou, Zhuo</creator><creator>Hu, Xiaodan</creator><creator>Chang, Shuquan</creator><creator>Liu, Peidang</creator><creator>Zhang, Haiqian</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180101</creationdate><title>Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells</title><author>Liu, Zhujun ; Tan, Hongye ; Zhang, Xiaohong ; Chen, Feng ; Zhou, Zhuo ; Hu, Xiaodan ; Chang, Shuquan ; Liu, Peidang ; Zhang, Haiqian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-23fedbd572e7bc1658f9a08b4d5f4614202dd9243ef2594071092f799416a6e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Apoptosis</topic><topic>Autophagy</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain tumors</topic><topic>Cell Hypoxia - drug effects</topic><topic>Cell Hypoxia - radiation effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Cell Survival - radiation effects</topic><topic>Crosstalk</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Glioma - radiotherapy</topic><topic>Glioma cells</topic><topic>Humans</topic><topic>Hypoxia</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>Nanoparticles</topic><topic>Phagocytosis</topic><topic>Radiation therapy</topic><topic>Radiation tolerance</topic><topic>Radiation-Sensitizing Agents - chemistry</topic><topic>Radiation-Sensitizing Agents - pharmacology</topic><topic>Radiosensitivity</topic><topic>Radiosensitization</topic><topic>Radiotherapy</topic><topic>Silver</topic><topic>Silver - chemistry</topic><topic>Silver - pharmacology</topic><topic>silver nanoparticles</topic><topic>Tumors</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Zhujun</creatorcontrib><creatorcontrib>Tan, Hongye</creatorcontrib><creatorcontrib>Zhang, Xiaohong</creatorcontrib><creatorcontrib>Chen, Feng</creatorcontrib><creatorcontrib>Zhou, Zhuo</creatorcontrib><creatorcontrib>Hu, Xiaodan</creatorcontrib><creatorcontrib>Chang, Shuquan</creatorcontrib><creatorcontrib>Liu, Peidang</creatorcontrib><creatorcontrib>Zhang, Haiqian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Zhujun</au><au>Tan, Hongye</au><au>Zhang, Xiaohong</au><au>Chen, Feng</au><au>Zhou, Zhuo</au><au>Hu, Xiaodan</au><au>Chang, Shuquan</au><au>Liu, Peidang</au><au>Zhang, Haiqian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>46</volume><issue>S3</issue><spage>922</spage><epage>930</epage><pages>922-930</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>Radiotherapy is one of the most widely used treatments for therapy of malignant tumors, but resistance to radiation of hypoxic cells in tumor tissues is still a serious concern. Previous studies have demonstrated that silver nanoparticles (AgNPs) enhance the radiosensitivity of human glioma cells in vitro, but the effect of AgNPs on hypoxic glioma cells has not been investigated in detail. The main purpose of this study is to evaluate the radiosensitizing efficacy of AgNPs on hypoxic glioma cells. The half maximal inhibitory concentration (IC50) values of AgNPs for the hypoxic U251 cells and C6 cells were 30.32 μg/mL and 27.53 μg/mL, respectively. The sensitization enhancement ratio (SER) demonstrated that AgNPs exhibit higher capacity in radiosensitization in hypoxic cells (U251: 1.78; C6: 1.84) than that in normoxic cells (U251: 1.34; C6: 1.45). The underlying mechanism of AgNPs' radiosensitization in hypoxic cells is through the promotion of apoptosis and enhanced destructive autophagy. There is evidence of crosstalk between apoptosis and autophagy in AgNPs-radiosensitized hypoxic cells where inhibition of autophagy results in decreased apoptosis. These findings suggest that AgNPs can be used as a highly effective nano-radiosensitizer for the treatment of hypoxic glioma.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>30307330</pmid><doi>10.1080/21691401.2018.1518912</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Apoptosis Autophagy Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Brain tumors Cell Hypoxia - drug effects Cell Hypoxia - radiation effects Cell Line, Tumor Cell Survival - drug effects Cell Survival - radiation effects Crosstalk Glioma - metabolism Glioma - pathology Glioma - radiotherapy Glioma cells Humans Hypoxia Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use Nanoparticles Phagocytosis Radiation therapy Radiation tolerance Radiation-Sensitizing Agents - chemistry Radiation-Sensitizing Agents - pharmacology Radiosensitivity Radiosensitization Radiotherapy Silver Silver - chemistry Silver - pharmacology silver nanoparticles Tumors X-Rays |
| title | Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells |
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