Zn 2+ -loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma
Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the le...
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| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2018-11, Vol.46 (sup2), p.912-920 |
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| container_title | Artificial cells, nanomedicine, and biotechnology |
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| creator | Yu, Huibin Ke, Hongqin Chen, Tu Li, Xing Tan, Shenglong Zhou, Lei Wang, Shenqi |
| description | Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn
loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn
-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn
concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with chitosan. In addition, the adsorbent shows better selectivity and storage stability and could be a potential adsorbent to treat prostate cancer. |
| doi_str_mv | 10.1080/21691401.2018.1473411 |
| format | Article |
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loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn
-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn
concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with chitosan. In addition, the adsorbent shows better selectivity and storage stability and could be a potential adsorbent to treat prostate cancer.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.1080/21691401.2018.1473411</identifier><identifier>PMID: 29774753</identifier><language>eng</language><publisher>England</publisher><ispartof>Artificial cells, nanomedicine, and biotechnology, 2018-11, Vol.46 (sup2), p.912-920</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1213-d9faa7ceffbecf46f6ac108888bcef1b9165420e92825f73d90f6ea6ed692f903</citedby><cites>FETCH-LOGICAL-c1213-d9faa7ceffbecf46f6ac108888bcef1b9165420e92825f73d90f6ea6ed692f903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29774753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Huibin</creatorcontrib><creatorcontrib>Ke, Hongqin</creatorcontrib><creatorcontrib>Chen, Tu</creatorcontrib><creatorcontrib>Li, Xing</creatorcontrib><creatorcontrib>Tan, Shenglong</creatorcontrib><creatorcontrib>Zhou, Lei</creatorcontrib><creatorcontrib>Wang, Shenqi</creatorcontrib><title>Zn 2+ -loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma</title><title>Artificial cells, nanomedicine, and biotechnology</title><addtitle>Artif Cells Nanomed Biotechnol</addtitle><description>Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn
loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn
-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn
concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with chitosan. In addition, the adsorbent shows better selectivity and storage stability and could be a potential adsorbent to treat prostate cancer.</description><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNo9kMtqwzAQRUVpaUKaT2jRvjjVyLJsLUvoCwLdtFC6MbI1alz8QnICCfTfK5PHbGbmDmcWh5BbYAtgGXvgIBUIBgvOIFuASGMBcEGmYx6BgK_L88xgQube_7JQGcg0EddkwlWaijSJp-Tvu6X8nkZ1pw0aWmJdb-rOIy1QG0_9oIuqrvbhVOxoua6GzuuW6tbQ3mGvXThsK02tQ9xjZNyuan-o7Rx12HTbcVlvmkAM6AM6oOtapFVL-1r7Rt-QK6trj_Njn5HP56eP5Wu0en95Wz6uohI4xJFRVuu0RGsLLK2QVuoyeAhVhBAKBTIRnKHiGU9sGhvFrEQt0UjFrWLxjCSHv6XrvHdo895VjXa7HFg-Gs1PRvPRaH40Gri7A9dvigbNmTr5i_8Bo6dzfA</recordid><startdate>20181105</startdate><enddate>20181105</enddate><creator>Yu, Huibin</creator><creator>Ke, Hongqin</creator><creator>Chen, Tu</creator><creator>Li, Xing</creator><creator>Tan, Shenglong</creator><creator>Zhou, Lei</creator><creator>Wang, Shenqi</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20181105</creationdate><title>Zn 2+ -loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma</title><author>Yu, Huibin ; Ke, Hongqin ; Chen, Tu ; Li, Xing ; Tan, Shenglong ; Zhou, Lei ; Wang, Shenqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1213-d9faa7ceffbecf46f6ac108888bcef1b9165420e92825f73d90f6ea6ed692f903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Huibin</creatorcontrib><creatorcontrib>Ke, Hongqin</creatorcontrib><creatorcontrib>Chen, Tu</creatorcontrib><creatorcontrib>Li, Xing</creatorcontrib><creatorcontrib>Tan, Shenglong</creatorcontrib><creatorcontrib>Zhou, Lei</creatorcontrib><creatorcontrib>Wang, Shenqi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Huibin</au><au>Ke, Hongqin</au><au>Chen, Tu</au><au>Li, Xing</au><au>Tan, Shenglong</au><au>Zhou, Lei</au><au>Wang, Shenqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zn 2+ -loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2018-11-05</date><risdate>2018</risdate><volume>46</volume><issue>sup2</issue><spage>912</spage><epage>920</epage><pages>912-920</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>Hemoperfusion using metal ion affinity adsorbent is a promising method to remove human testosterone in plasma. Due to the leakage of metal ion from the adsorbents, there is no metal ion affinity adsorbent for hemoperfusion. In this study, chitosan was used to coat the adsorbent for preventing the leakage of Zn
loaded. Meanwhile, freeze-drying method was used to enhance adsorption capacity of Zn
-loaded cellulose beads for testosterone. The results indicate that after the adsorbent was coated by 0.02% chitosan solution, the highest adsorption percentage reached 48%, during adsorption, the Zn
concentration in plasma did not increase; the adsorption capacity of the adsorbent can be significantly enhanced by freeze-drying. The results may be caused by porosity of the adsorbent enlarged via freeze-drying and improved stability by coating with chitosan. In addition, the adsorbent shows better selectivity and storage stability and could be a potential adsorbent to treat prostate cancer.</abstract><cop>England</cop><pmid>29774753</pmid><doi>10.1080/21691401.2018.1473411</doi><tpages>9</tpages></addata></record> |
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| source | Alma/SFX Local Collection |
| title | Zn 2+ -loaded cellulose beads stabilized by chitosan and prepared via freeze-drying for removing human testosterone in plasma |
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