Claudin-18.2 as a therapeutic target in cancers: cumulative findings from basic research and clinical trials

Claudins are major components of tight junctions that maintain cell polarity and intercellular adhesion. The dynamics of claudins in cancer cells have attracted attention as a therapeutic target. During carcinogenesis, claudin expression is generally downregulated; however, overexpression of claudin...

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Veröffentlicht in:	Tissue barriers 2022-01, Vol.10 (1), p.1967080
Hauptverfasser:	Kyuno, Daisuke, Takasawa, Akira, Takasawa, Kumi, Ono, Yusuke, Aoyama, Tomoyuki, Magara, Kazufumi, Nakamori, Yuna, Takemasa, Ichiro, Osanai, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer Carcinogenesis - metabolism Cell Adhesion Molecules - metabolism claudin-18.2 Claudins - metabolism Humans Neoplasms - drug therapy Neoplasms - metabolism Review Tight junction Tight Junctions - metabolism zolbetuximab
Online-Zugang:	Volltext
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