Poly(amido amine) dendrimers in oral delivery
Poly(amidoamine) (PAMAM) dendrimers have been extensively investigated for oral delivery applications due to their ability to translocate across the gastrointestinal epithelium. In this Review, we highlight recent advances in the evaluation of PAMAM dendrimers as oral drug delivery carriers. Specifi...
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| Veröffentlicht in: | Tissue barriers 2016-04, Vol.4 (2), p.e1173773-e1173773 |
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| container_title | Tissue barriers |
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| creator | Yellepeddi, Venkata K. Ghandehari, Hamidreza |
| description | Poly(amidoamine) (PAMAM) dendrimers have been extensively investigated for oral delivery applications due to their ability to translocate across the gastrointestinal epithelium. In this Review, we highlight recent advances in the evaluation of PAMAM dendrimers as oral drug delivery carriers. Specifically, toxicity, mechanisms of transepithelial transport, models of the intestinal epithelial barrier including isolated human intestinal tissue model, detection of dendrimers, and surface modification are discussed. We also highlight evaluation of various PAMAM dendrimer-drug conjugates for their ability to transport across gastrointestinal epithelium for improved oral bioavailability. In addition, current challenges and future trends for clinical translation of PAMAM dendrimers as carriers for oral delivery are discussed. |
| doi_str_mv | 10.1080/21688370.2016.1173773 |
| format | Article |
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In addition, current challenges and future trends for clinical translation of PAMAM dendrimers as carriers for oral delivery are discussed.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>bioavailability</subject><subject>Caco-2 monolayer</subject><subject>complexation</subject><subject>conjugation</subject><subject>cytotoxicity</subject><subject>Dendrimers - administration & dosage</subject><subject>Dendrimers - adverse effects</subject><subject>Dendrimers - chemistry</subject><subject>Dendrimers - pharmacokinetics</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>PAMAM dendrimers</subject><subject>permeability</subject><subject>Polyamines - chemistry</subject><subject>Review</subject><subject>translocation</subject><subject>ussing chamber</subject><issn>2168-8362</issn><issn>2168-8370</issn><issn>2168-8370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PAyEQhonR2Kb2J2h6rIetA9Nd8GI0jV-JiR70TFhgFbO7VGhr-u9l04_oRQ4wzLzzzuQh5JTChIKAC0YLIZDDhAEtJpRy5BwPSL_LZ13hcB8XrEeGMX5COoIVwKfHpMc45oLneZ9kL75ej1XjjB-lu7XnI2NbE1xjQxy5duSDqlOqdisb1ifkqFJ1tMPtOyBvd7evs4fs6fn-cXbzlOkcxSKzkBsOyASj3CAtMP2p5RrKslDWQAklp1pr1AhaQIGsRGRVyVQBJjcKB-Rq4ztflo012raLtIacp7VUWEuvnPxbad2HfPcrOb1MfHCaDMZbg-C_ljYuZOOitnWtWuuXUVIBdIqUQyfNN1IdfIzBVvsxFGRHW-5oy4623NJOfWe_d9x37dgmwfVG4NrKh0Z9-1AbuVDr2ocqqFa7KPH_GT_iYY3s</recordid><startdate>20160402</startdate><enddate>20160402</enddate><creator>Yellepeddi, Venkata K.</creator><creator>Ghandehari, Hamidreza</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160402</creationdate><title>Poly(amido amine) dendrimers in oral delivery</title><author>Yellepeddi, Venkata K. ; Ghandehari, Hamidreza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-e05d70328217d316305d1e7c0bb6aed0b0b71ccc3c30c80632b332fb2a60d5da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>bioavailability</topic><topic>Caco-2 monolayer</topic><topic>complexation</topic><topic>conjugation</topic><topic>cytotoxicity</topic><topic>Dendrimers - administration & dosage</topic><topic>Dendrimers - adverse effects</topic><topic>Dendrimers - chemistry</topic><topic>Dendrimers - pharmacokinetics</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>PAMAM dendrimers</topic><topic>permeability</topic><topic>Polyamines - chemistry</topic><topic>Review</topic><topic>translocation</topic><topic>ussing chamber</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yellepeddi, Venkata K.</creatorcontrib><creatorcontrib>Ghandehari, Hamidreza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Tissue barriers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yellepeddi, Venkata K.</au><au>Ghandehari, Hamidreza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Poly(amido amine) dendrimers in oral delivery</atitle><jtitle>Tissue barriers</jtitle><addtitle>Tissue Barriers</addtitle><date>2016-04-02</date><risdate>2016</risdate><volume>4</volume><issue>2</issue><spage>e1173773</spage><epage>e1173773</epage><pages>e1173773-e1173773</pages><issn>2168-8362</issn><issn>2168-8370</issn><eissn>2168-8370</eissn><abstract>Poly(amidoamine) (PAMAM) dendrimers have been extensively investigated for oral delivery applications due to their ability to translocate across the gastrointestinal epithelium. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Administration, Oral Animals bioavailability Caco-2 monolayer complexation conjugation cytotoxicity Dendrimers - administration & dosage Dendrimers - adverse effects Dendrimers - chemistry Dendrimers - pharmacokinetics Humans Intestinal Absorption PAMAM dendrimers permeability Polyamines - chemistry Review translocation ussing chamber |
| title | Poly(amido amine) dendrimers in oral delivery |
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