Impaired proliferation and migration of HUVEC and melanoma cells by human anti-FGF2 mAbs derived from a murine hybridoma by guided selection

Disadvantages of using murine monoclonal antibodies (mAb) in human therapy, such as immunogenicity response, led to the development of technologies to transform murine antibodies into human antibodies. The murine anti-FGF2 3F12E7 mAb was proposed as a promising agent to treat metastatic melanoma tum...

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Veröffentlicht in:	Bioengineered 2023-12, Vol.14 (1), p.2252667-2252667
Hauptverfasser:	Georg Magalhães, Carolina, Ploeger Mansueli, Carla, Manieri, Tânia Maria, Quintilio, Wagner, Garbuio, Angélica, de Jesus Marinho, Juan, de Moraes, Jane Zveiter, Tsuruta, Lilian Rumi, Moro, Ana Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibody humanization fibroblast growth factor 2 fragment antigen-binding guided selection phage display
Online-Zugang:	Volltext
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