BAY-885, a mitogen-activated protein kinase kinase 5 inhibitor, induces apoptosis by regulating the endoplasmic reticulum stress/Mcl-1/Bim pathway in breast cancer cells

The mitogen-activated protein kinase kinase 5 (MEK5)/extracellular signal-regulated kinase 5 (ERK5) axis has been reported to promote tumorigenesis in breast cancer (BC). Therefore, targeting the MEK5/ERK5 axis is a potential strategy against BC. BAY-885 is a novel inhibitor of ERK5; however, to dat...

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Veröffentlicht in:	Bioengineered 2022-05, Vol.13 (5), p.12888-12898
Hauptverfasser:	Wang, Lei, Ji, Xiaochun, Mao, Chenxiao, Yu, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis Regulatory Proteins - metabolism BAY-885 Breast cancer Breast Neoplasms - metabolism Endoplasmic Reticulum Stress ERK5 Female Humans MAP Kinase Kinase 5 - genetics MAP Kinase Kinase 5 - metabolism mcl-1 Research Paper
Online-Zugang:	Volltext
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