HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection
The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classi...
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| Veröffentlicht in: | Human vaccines & immunotherapeutics 2019-08, Vol.15 (7-8), p.1920-1928 |
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| container_issue | 7-8 |
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| container_title | Human vaccines & immunotherapeutics |
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| creator | Timbang, Mary Roz Sim, Michael W. Bewley, Arnaud F. Farwell, D. Gregory Mantravadi, Avinash Moore, Michael G. |
| description | The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classic risk factors such as tobacco and alcohol use. Currently, there are no approved approaches for prevention and early detection of disease, thus leading many patients to present with advanced cancers requiring intense surgical or nonsurgical therapies resulting in significant side effects and cost to the health-care system. In this review, we outline the evolving epidemiology of HPV-related OPC. We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. Finally, we describe emerging techniques for identifying and screening those who may be at high risk for developing these tumors. |
| doi_str_mv | 10.1080/21645515.2019.1600985 |
| format | Article |
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We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. 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Gregory</creatorcontrib><creatorcontrib>Mantravadi, Avinash</creatorcontrib><creatorcontrib>Moore, Michael G.</creatorcontrib><title>HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection</title><title>Human vaccines & immunotherapeutics</title><addtitle>Hum Vaccin Immunother</addtitle><description>The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classic risk factors such as tobacco and alcohol use. Currently, there are no approved approaches for prevention and early detection of disease, thus leading many patients to present with advanced cancers requiring intense surgical or nonsurgical therapies resulting in significant side effects and cost to the health-care system. In this review, we outline the evolving epidemiology of HPV-related OPC. We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. Finally, we describe emerging techniques for identifying and screening those who may be at high risk for developing these tumors.</description><subject>Carcinoma, Squamous Cell - prevention & control</subject><subject>Carcinoma, Squamous Cell - virology</subject><subject>Cost of Illness</subject><subject>detection</subject><subject>Early Detection of Cancer</subject><subject>Head and Neck Neoplasms - prevention & control</subject><subject>Head and Neck Neoplasms - virology</subject><subject>HPV</subject><subject>Humans</subject><subject>Incidence</subject><subject>Oropharyngeal cancer</subject><subject>Oropharyngeal Neoplasms - prevention & control</subject><subject>Oropharyngeal Neoplasms - virology</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - prevention & control</subject><subject>Papillomavirus Vaccines - administration & dosage</subject><subject>prevention</subject><subject>Review</subject><subject>Risk Factors</subject><subject>screening</subject><subject>United States</subject><subject>vaccination</subject><issn>2164-5515</issn><issn>2164-554X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9Uk1v1DAQjRCIVqU_AeQjlyy2YzsJBwSqCq1UCQ6AuFn-GO-6ytrBTlr23-N0tyt6wZexZt57M6N5VfWa4BXBHX5HiWCcE76imPQrIjDuO_6sOl3yNefs1_Pjn_CT6jznW1xeiykT4mV10hDMMe_5afXn6tvPOsGgJrAopjhuVNqFNagBGRUMpPdIoQR3Hu5RDEjPyUJA0aFpA8j6DCoDUqFwxzGmaQ5-8pCRiwmNhQZh8oW2AEClYYcsTGCW3KvqhVNDhvNDPKt-fL78fnFV33z9cn3x6aY2vGFTbRqsTOeM49rphvZYd8TgjveE9m1Z3GiCLaeNII7xUmGCY-FAG8dU37q2Oauu97o2qls5Jr8tC8qovHxIxLSWKk3eDCA55Ybi1jjdMWaV1qy3xIiOka5t8IPWh73WOOstWFO2S2p4Ivq0EvxGruOdFG2Zi4gi8PYgkOLvGfIktz4bGAYVIM5ZUkp72lBGmwLle6hJMecE7tiGYLmYQD6aQC4mkAcTFN6bf2c8sh5PXgAf9wAfypW26j6mwcpJ7YaYXCo393kB_6_HX0ivwqc</recordid><startdate>20190803</startdate><enddate>20190803</enddate><creator>Timbang, Mary Roz</creator><creator>Sim, Michael W.</creator><creator>Bewley, Arnaud F.</creator><creator>Farwell, D. Gregory</creator><creator>Mantravadi, Avinash</creator><creator>Moore, Michael G.</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-8237-2873</orcidid></search><sort><creationdate>20190803</creationdate><title>HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection</title><author>Timbang, Mary Roz ; Sim, Michael W. ; Bewley, Arnaud F. ; Farwell, D. Gregory ; Mantravadi, Avinash ; Moore, Michael G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-c30ac8fcf5bfb3290b81c08591297160cb10d52361f451c046506febcf4a97f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Carcinoma, Squamous Cell - prevention & control</topic><topic>Carcinoma, Squamous Cell - virology</topic><topic>Cost of Illness</topic><topic>detection</topic><topic>Early Detection of Cancer</topic><topic>Head and Neck Neoplasms - prevention & control</topic><topic>Head and Neck Neoplasms - virology</topic><topic>HPV</topic><topic>Humans</topic><topic>Incidence</topic><topic>Oropharyngeal cancer</topic><topic>Oropharyngeal Neoplasms - prevention & control</topic><topic>Oropharyngeal Neoplasms - virology</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - prevention & control</topic><topic>Papillomavirus Vaccines - administration & dosage</topic><topic>prevention</topic><topic>Review</topic><topic>Risk Factors</topic><topic>screening</topic><topic>United States</topic><topic>vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Timbang, Mary Roz</creatorcontrib><creatorcontrib>Sim, Michael W.</creatorcontrib><creatorcontrib>Bewley, Arnaud F.</creatorcontrib><creatorcontrib>Farwell, D. 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| subjects | Carcinoma, Squamous Cell - prevention & control Carcinoma, Squamous Cell - virology Cost of Illness detection Early Detection of Cancer Head and Neck Neoplasms - prevention & control Head and Neck Neoplasms - virology HPV Humans Incidence Oropharyngeal cancer Oropharyngeal Neoplasms - prevention & control Oropharyngeal Neoplasms - virology Papillomaviridae - pathogenicity Papillomavirus Infections - complications Papillomavirus Infections - prevention & control Papillomavirus Vaccines - administration & dosage prevention Review Risk Factors screening United States vaccination |
| title | HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection |
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