Immune priming and induction of tertiary lymphoid structures in a cord-blood humanized mouse model of gastrointestinal stromal tumor

Gastrointestinal stromal tumors (GISTs) harbor diverse immune cell populations but so far immunotherapy in patients has been disappointing. Here, we established cord blood humanized mouse models of localized and disseminated GIST to explore the remodeling of the tumor environment for improved immuno...

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Veröffentlicht in:	Oncoimmunology 2024-12, Vol.13 (1), p.2406576
Hauptverfasser:	He, Bo, Dymond, Larissa, Wood, Kira H., Bastow, Edward R., Satiaputra, Jiulia, Li, Ji, Johansson-Percival, Anna, Hamzah, Juliana, Kumarasinghe, M. Priyanthi, Ballal, Mohammed, Foo, Jonathan, Johansson, Mikael, Ee, Hooi C., White, Scott W., Winteringham, Louise, Ganss, Ruth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Disease Models, Animal Fetal Blood - cytology Gastrointestinal Neoplasms - immunology Gastrointestinal Neoplasms - pathology Gastrointestinal Neoplasms - therapy Gastrointestinal Stromal Tumors - immunology Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - therapy Gastrointestinal tumor (GIST) humanized mice Humans Immunotherapy - methods LIGHT (TNFS14) Mice Neovascularization, Pathologic - immunology Neovascularization, Pathologic - pathology Original Research tertiary lymphoid structures (TLS) Tertiary Lymphoid Structures - immunology Tertiary Lymphoid Structures - pathology Tumor Microenvironment - immunology Tumor Necrosis Factor Ligand Superfamily Member 14 - genetics Tumor Necrosis Factor Ligand Superfamily Member 14 - metabolism vascular targeting Xenograft Model Antitumor Assays
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