Reprogramming the immunosuppressive tumor microenvironment results in successful clearance of tumors resistant to radiation therapy and anti-PD-1/PD-L1

Despite breakthroughs in immune checkpoint inhibitors (ICI), the majority of tumors, including those poorly infiltrated by CD8+ T cells or heavily infiltrated by immunosuppressive immune effector cells, are unlikely to result in clinically meaningful tumor responses. Radiation therapy (RT) has been...

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Veröffentlicht in:	Oncoimmunology 2023-12, Vol.12 (1), p.2223094-2223094
Hauptverfasser:	Mukherjee, Debayan, Romano, Erminia, Walshaw, Richard, Zeef, Leo A. H., Banyard, Antonia, Kitcatt, Stephen J., Cheadle, Eleanor J., Tuomela, Karoliina, Pendharkar, Swati, Al-Deka, Aws, Salerno, Beatrice, Raby, Sophie, Mills, Ian G., Honeychurch, Jamie, Illidge, Tim M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Combined Modality Therapy Humans immune Checkpoints immunotherapy Male Original Research Radiotherapy Signal Transduction T-Lymphocytes, Regulatory - metabolism Tregs Tumor Microenvironment Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - radiotherapy
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