Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy

Emerging evidence suggests that NLRP3 inflammasome provides a link between colitis-associated colorectal cancer and inflammatory bowel diseases. Autophagy is induced in macrophages by AMPK activation and regulates NLRP3 inflammasome to maintain intracellular homeostasis. Here we report that a small-...

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Veröffentlicht in:	Oncoimmunology 2018-01, Vol.7 (1), p.e1375640
Hauptverfasser:	Zhao, Yue, Guo, Qinglong, Zhao, Kai, Zhou, Yuxin, Li, Wenjun, Pan, Chuyue, Qiang, Lei, Li, Zhiyu, Lu, Na
Format:	Artikel
Sprache:	eng
Schlagworte:	autophagy colitis colitis-associated colorectal cancer GL-V9 NLRP3 inflammasome Original Research
Online-Zugang:	Volltext
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