Nonreplicative functions of the origin recognition complex
Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well. The majori...
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| Veröffentlicht in: | Nucleus (Austin, Tex.) Tex.), 2018-01, Vol.9 (1), p.460-473 |
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| creator | Popova, Varvara V. Brechalov, Alexander V. Georgieva, Sofia G. Kopytova, Daria V. |
| description | Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well. The majority of these functions, such as heterochromatin formation, chromosome condensation, and segregation are dependent on ORC-DNA interactions. Furthermore, ORC is involved in the control of cell division via its participation in centrosome duplication and cytokinesis. Recent findings have also demonstrated a direct interaction between ORC and mRNPs and highlighted an essential role of ORC in mRNA nuclear export. Along with the growth of evolutionary complexity of organisms, ORC complex functions become more elaborate and new functions of the ORC sub-complexes and individual subunits have emerged. |
| doi_str_mv | 10.1080/19491034.2018.1516484 |
| format | Article |
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Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well. The majority of these functions, such as heterochromatin formation, chromosome condensation, and segregation are dependent on ORC-DNA interactions. Furthermore, ORC is involved in the control of cell division via its participation in centrosome duplication and cytokinesis. Recent findings have also demonstrated a direct interaction between ORC and mRNPs and highlighted an essential role of ORC in mRNA nuclear export. 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Along with the growth of evolutionary complexity of organisms, ORC complex functions become more elaborate and new functions of the ORC sub-complexes and individual subunits have emerged.</description><subject>Animals</subject><subject>centrosomes</subject><subject>chromosome morphology</subject><subject>cohesin</subject><subject>cytokinesis</subject><subject>heterochromatin</subject><subject>HP1</subject><subject>Humans</subject><subject>mRNA export</subject><subject>mRNP</subject><subject>ORC</subject><subject>Origin recognition complex</subject><subject>Origin Recognition Complex - metabolism</subject><subject>physiological transport</subject><subject>Review</subject><subject>SIR</subject><subject>sister chromatids</subject><subject>TREX-2</subject><subject>yeasts</subject><issn>1949-1034</issn><issn>1949-1042</issn><issn>1949-1042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNqFUU1PGzEQtVARQYGfQLVHLgkz_tgPDhUVakulCC5wtryOHVzt2sHeQPPvcZQPtReYi0eeN2_mzSPkAmGKUMMVNrxBYHxKAespCix5zY_I6eZ_gsDpl0PO-Iicp_QHcnBegcATMmKATVkJfkqu74OPZtk5rQb3agq78npwwaci2GJ4NkWIbuF8EY0OC-82pUKHftmZv2fk2KoumfPdOyZPP3883t5NZg-_ft9-n020ABwmmqu2ahRQZkvkjW5balTVzBFaWkILuhaalVhZAU2pETS3VRZXsVoIOm8VG5NvW97lqu3NXBs_RNXJZXS9imsZlJP_V7x7lovwKkuaBTOeCS53BDG8rEwaZO-SNl2nvAmrJKmgnDKet_0civlySDHfdUzEFqpjSCkae9gIQW5cknuX5MYluXMp9339V86ha-9JBtxsAc7bEHv1FmI3l4NadyHaqLx2SbKPZ7wDNmug2w</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Popova, Varvara V.</creator><creator>Brechalov, Alexander V.</creator><creator>Georgieva, Sofia G.</creator><creator>Kopytova, Daria V.</creator><general>Taylor & Francis</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0540-4517</orcidid><orcidid>https://orcid.org/0000-0003-3665-0390</orcidid><orcidid>https://orcid.org/0000-0003-1086-6329</orcidid><orcidid>https://orcid.org/0000-0003-2726-1676</orcidid></search><sort><creationdate>20180101</creationdate><title>Nonreplicative functions of the origin recognition complex</title><author>Popova, Varvara V. ; Brechalov, Alexander V. ; Georgieva, Sofia G. ; Kopytova, Daria V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-c4ab79a023f6149cbb2ea79d10b260b0c85c3617f5096c10c4f7910738552dba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>centrosomes</topic><topic>chromosome morphology</topic><topic>cohesin</topic><topic>cytokinesis</topic><topic>heterochromatin</topic><topic>HP1</topic><topic>Humans</topic><topic>mRNA export</topic><topic>mRNP</topic><topic>ORC</topic><topic>Origin recognition complex</topic><topic>Origin Recognition Complex - metabolism</topic><topic>physiological transport</topic><topic>Review</topic><topic>SIR</topic><topic>sister chromatids</topic><topic>TREX-2</topic><topic>yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popova, Varvara V.</creatorcontrib><creatorcontrib>Brechalov, Alexander V.</creatorcontrib><creatorcontrib>Georgieva, Sofia G.</creatorcontrib><creatorcontrib>Kopytova, Daria V.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleus (Austin, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popova, Varvara V.</au><au>Brechalov, Alexander V.</au><au>Georgieva, Sofia G.</au><au>Kopytova, Daria V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonreplicative functions of the origin recognition complex</atitle><jtitle>Nucleus (Austin, Tex.)</jtitle><addtitle>Nucleus</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>9</volume><issue>1</issue><spage>460</spage><epage>473</epage><pages>460-473</pages><issn>1949-1034</issn><issn>1949-1042</issn><eissn>1949-1042</eissn><abstract>Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. 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| source | Taylor & Francis Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals centrosomes chromosome morphology cohesin cytokinesis heterochromatin HP1 Humans mRNA export mRNP ORC Origin recognition complex Origin Recognition Complex - metabolism physiological transport Review SIR sister chromatids TREX-2 yeasts |
| title | Nonreplicative functions of the origin recognition complex |
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