Abnormalities in gut virome signatures linked with cognitive impairment in older adults
Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to...
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| Veröffentlicht in: | Gut microbes 2024-12, Vol.16 (1), p.2431648 |
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| creator | James, Adewale S. Adil, Noorul A. Goltz, Dayna Tangudu, Divyani Chaudhari, Diptaraj S. Shukla, Rohit Kumar, Vivek Kumar, Ambuj Masternak, Michal M. Holland, Peter Labyak, Corinne Golden, Adam Dangiolo, Mariana Arikawa, Andrea Y. Kociolek, Judyta Fraser, Amoy Williams, Cynthia Agronin, Marc Aymat, Mariolga Jain, Shalini Yadav, Hariom |
| description | Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets (n = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs. 70s vs. 80+ years of age) in older adults. We observed that the predominant virome signature was enriched with bacteriophages, which change considerably with aging continuum. Analyses of interactions between phages and the host bacteriome suggest that lytic or temperate relationships change distinctly across the aging continuum, as well as cognitive impairment. Interestingly, the phage-bacteriome-metabolome interactions develop unique patterns that are distinctly linked to aging and cognitive dysfunction in older adults. The phage-bacteriome interactions affect bacterial metabolic pathways, potentially impacting older adults' health, including the risk of cognitive decline and dementia. Further comprehension of these studies could provide opportunities to target the microbiome by developing phage therapies to improve aging and brain health in older adults. |
| doi_str_mv | 10.1080/19490976.2024.2431648 |
| format | Article |
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However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets (n = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs. 70s vs. 80+ years of age) in older adults. We observed that the predominant virome signature was enriched with bacteriophages, which change considerably with aging continuum. Analyses of interactions between phages and the host bacteriome suggest that lytic or temperate relationships change distinctly across the aging continuum, as well as cognitive impairment. Interestingly, the phage-bacteriome-metabolome interactions develop unique patterns that are distinctly linked to aging and cognitive dysfunction in older adults. The phage-bacteriome interactions affect bacterial metabolic pathways, potentially impacting older adults' health, including the risk of cognitive decline and dementia. Further comprehension of these studies could provide opportunities to target the microbiome by developing phage therapies to improve aging and brain health in older adults.</description><identifier>ISSN: 1949-0976</identifier><identifier>ISSN: 1949-0984</identifier><identifier>EISSN: 1949-0984</identifier><identifier>DOI: 10.1080/19490976.2024.2431648</identifier><identifier>PMID: 39676708</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Bacteria - classification ; Bacteria - genetics ; Bacteria - isolation & purification ; Bacteria - metabolism ; Bacteria - virology ; Bacteriophages - classification ; Bacteriophages - genetics ; Bacteriophages - isolation & purification ; cognition ; Cognitive Dysfunction - microbiology ; Cognitive Dysfunction - virology ; dementia ; Female ; Gastrointestinal Microbiome ; gut ; Humans ; Male ; Metabolome ; microbiome ; Middle Aged ; phage ; Pilot Projects ; Research Paper ; Virome</subject><ispartof>Gut microbes, 2024-12, Vol.16 (1), p.2431648</ispartof><rights>2024 The Author(s). Published with license by Taylor & Francis Group, LLC. 2024</rights><rights>2024 The Author(s). Published with license by Taylor & Francis Group, LLC. 2024 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-f86b4b18fafac52e0d63eabcc34685928f7370aa368e3daa2397ecd505ebf6843</cites><orcidid>0000-0001-8794-0748 ; 0000-0003-3276-8914 ; 0000-0003-4504-1597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651276/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651276/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,27481,27903,27904,53769,53771,59119,59120</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39676708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>James, Adewale S.</creatorcontrib><creatorcontrib>Adil, Noorul A.</creatorcontrib><creatorcontrib>Goltz, Dayna</creatorcontrib><creatorcontrib>Tangudu, Divyani</creatorcontrib><creatorcontrib>Chaudhari, Diptaraj S.</creatorcontrib><creatorcontrib>Shukla, Rohit</creatorcontrib><creatorcontrib>Kumar, Vivek</creatorcontrib><creatorcontrib>Kumar, Ambuj</creatorcontrib><creatorcontrib>Masternak, Michal M.</creatorcontrib><creatorcontrib>Holland, Peter</creatorcontrib><creatorcontrib>Labyak, Corinne</creatorcontrib><creatorcontrib>Golden, Adam</creatorcontrib><creatorcontrib>Dangiolo, Mariana</creatorcontrib><creatorcontrib>Arikawa, Andrea Y.</creatorcontrib><creatorcontrib>Kociolek, Judyta</creatorcontrib><creatorcontrib>Fraser, Amoy</creatorcontrib><creatorcontrib>Williams, Cynthia</creatorcontrib><creatorcontrib>Agronin, Marc</creatorcontrib><creatorcontrib>Aymat, Mariolga</creatorcontrib><creatorcontrib>Jain, Shalini</creatorcontrib><creatorcontrib>Yadav, Hariom</creatorcontrib><title>Abnormalities in gut virome signatures linked with cognitive impairment in older adults</title><title>Gut microbes</title><addtitle>Gut Microbes</addtitle><description>Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets (n = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs. 70s vs. 80+ years of age) in older adults. We observed that the predominant virome signature was enriched with bacteriophages, which change considerably with aging continuum. Analyses of interactions between phages and the host bacteriome suggest that lytic or temperate relationships change distinctly across the aging continuum, as well as cognitive impairment. Interestingly, the phage-bacteriome-metabolome interactions develop unique patterns that are distinctly linked to aging and cognitive dysfunction in older adults. The phage-bacteriome interactions affect bacterial metabolic pathways, potentially impacting older adults' health, including the risk of cognitive decline and dementia. Further comprehension of these studies could provide opportunities to target the microbiome by developing phage therapies to improve aging and brain health in older adults.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Bacteria - classification</subject><subject>Bacteria - genetics</subject><subject>Bacteria - isolation & purification</subject><subject>Bacteria - metabolism</subject><subject>Bacteria - virology</subject><subject>Bacteriophages - classification</subject><subject>Bacteriophages - genetics</subject><subject>Bacteriophages - isolation & purification</subject><subject>cognition</subject><subject>Cognitive Dysfunction - microbiology</subject><subject>Cognitive Dysfunction - virology</subject><subject>dementia</subject><subject>Female</subject><subject>Gastrointestinal Microbiome</subject><subject>gut</subject><subject>Humans</subject><subject>Male</subject><subject>Metabolome</subject><subject>microbiome</subject><subject>Middle Aged</subject><subject>phage</subject><subject>Pilot Projects</subject><subject>Research Paper</subject><subject>Virome</subject><issn>1949-0976</issn><issn>1949-0984</issn><issn>1949-0984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU1v1DAQhiMEolXpTwDlyGUXO3Zs5wRVVUqlSlxAHK3x19bFsRc72ar_Hqe7XdELvtiaeeedGT9N8x6jNUYCfcIDHdDA2bpDHV13lGBGxavmdImv0CDo6-Obs5PmvJR7VA-lHDHytjkhA-OMI3Ha_LpQMeURgp-8La2P7Wae2p3PabRt8ZsI05xrIvj425r2wU93rU6bWOU72_pxCz6PNk5LZQrG5hbMHKbyrnnjIBR7frjPmp9fr35cflvdfr--uby4XWnC2LRygimqsHDgQPedRYYRC0prQpnoh044TjgCIExYYgA6MnCrTY96qxwTlJw1N3tfk-BebrMfIT_KBF4-BVLeSMiT18FKGJRyijpkCFBnlHC046J-HHfaKK6q1-e913ZWozW6rpUhvDB9mYn-Tm7STmLMetxxVh0-Hhxy-jPbMsnRF21DgGjTXCTBda0FHanSfi_VOZWSrTv2wUgukOUzZLlAlgfIte7Dv0Meq56RVsGXvcBHt5B9SDkYOcFjSNlliNovc_y3x18GM7mp</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>James, Adewale S.</creator><creator>Adil, Noorul A.</creator><creator>Goltz, Dayna</creator><creator>Tangudu, Divyani</creator><creator>Chaudhari, Diptaraj S.</creator><creator>Shukla, Rohit</creator><creator>Kumar, Vivek</creator><creator>Kumar, Ambuj</creator><creator>Masternak, Michal M.</creator><creator>Holland, Peter</creator><creator>Labyak, Corinne</creator><creator>Golden, Adam</creator><creator>Dangiolo, Mariana</creator><creator>Arikawa, Andrea Y.</creator><creator>Kociolek, Judyta</creator><creator>Fraser, Amoy</creator><creator>Williams, Cynthia</creator><creator>Agronin, Marc</creator><creator>Aymat, Mariolga</creator><creator>Jain, Shalini</creator><creator>Yadav, Hariom</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8794-0748</orcidid><orcidid>https://orcid.org/0000-0003-3276-8914</orcidid><orcidid>https://orcid.org/0000-0003-4504-1597</orcidid></search><sort><creationdate>20241231</creationdate><title>Abnormalities in gut virome signatures linked with cognitive impairment in older adults</title><author>James, Adewale S. ; Adil, Noorul A. ; Goltz, Dayna ; Tangudu, Divyani ; Chaudhari, Diptaraj S. ; Shukla, Rohit ; Kumar, Vivek ; Kumar, Ambuj ; Masternak, Michal M. ; Holland, Peter ; Labyak, Corinne ; Golden, Adam ; Dangiolo, Mariana ; Arikawa, Andrea Y. ; Kociolek, Judyta ; Fraser, Amoy ; Williams, Cynthia ; Agronin, Marc ; Aymat, Mariolga ; Jain, Shalini ; Yadav, Hariom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-f86b4b18fafac52e0d63eabcc34685928f7370aa368e3daa2397ecd505ebf6843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Bacteria - classification</topic><topic>Bacteria - genetics</topic><topic>Bacteria - isolation & purification</topic><topic>Bacteria - metabolism</topic><topic>Bacteria - virology</topic><topic>Bacteriophages - classification</topic><topic>Bacteriophages - genetics</topic><topic>Bacteriophages - isolation & purification</topic><topic>cognition</topic><topic>Cognitive Dysfunction - microbiology</topic><topic>Cognitive Dysfunction - virology</topic><topic>dementia</topic><topic>Female</topic><topic>Gastrointestinal Microbiome</topic><topic>gut</topic><topic>Humans</topic><topic>Male</topic><topic>Metabolome</topic><topic>microbiome</topic><topic>Middle Aged</topic><topic>phage</topic><topic>Pilot Projects</topic><topic>Research Paper</topic><topic>Virome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>James, Adewale S.</creatorcontrib><creatorcontrib>Adil, Noorul A.</creatorcontrib><creatorcontrib>Goltz, Dayna</creatorcontrib><creatorcontrib>Tangudu, Divyani</creatorcontrib><creatorcontrib>Chaudhari, Diptaraj S.</creatorcontrib><creatorcontrib>Shukla, Rohit</creatorcontrib><creatorcontrib>Kumar, Vivek</creatorcontrib><creatorcontrib>Kumar, Ambuj</creatorcontrib><creatorcontrib>Masternak, Michal M.</creatorcontrib><creatorcontrib>Holland, Peter</creatorcontrib><creatorcontrib>Labyak, Corinne</creatorcontrib><creatorcontrib>Golden, Adam</creatorcontrib><creatorcontrib>Dangiolo, Mariana</creatorcontrib><creatorcontrib>Arikawa, Andrea Y.</creatorcontrib><creatorcontrib>Kociolek, Judyta</creatorcontrib><creatorcontrib>Fraser, Amoy</creatorcontrib><creatorcontrib>Williams, Cynthia</creatorcontrib><creatorcontrib>Agronin, Marc</creatorcontrib><creatorcontrib>Aymat, Mariolga</creatorcontrib><creatorcontrib>Jain, Shalini</creatorcontrib><creatorcontrib>Yadav, Hariom</creatorcontrib><collection>Taylor & Francis Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Gut microbes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>James, Adewale S.</au><au>Adil, Noorul A.</au><au>Goltz, Dayna</au><au>Tangudu, Divyani</au><au>Chaudhari, Diptaraj S.</au><au>Shukla, Rohit</au><au>Kumar, Vivek</au><au>Kumar, Ambuj</au><au>Masternak, Michal M.</au><au>Holland, Peter</au><au>Labyak, Corinne</au><au>Golden, Adam</au><au>Dangiolo, Mariana</au><au>Arikawa, Andrea Y.</au><au>Kociolek, Judyta</au><au>Fraser, Amoy</au><au>Williams, Cynthia</au><au>Agronin, Marc</au><au>Aymat, Mariolga</au><au>Jain, Shalini</au><au>Yadav, Hariom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormalities in gut virome signatures linked with cognitive impairment in older adults</atitle><jtitle>Gut microbes</jtitle><addtitle>Gut Microbes</addtitle><date>2024-12-31</date><risdate>2024</risdate><volume>16</volume><issue>1</issue><spage>2431648</spage><pages>2431648-</pages><issn>1949-0976</issn><issn>1949-0984</issn><eissn>1949-0984</eissn><abstract>Multiple emerging lines of evidence indicate that the microbiome contributes to aging and cognitive health. However, the roles of distinct microbial components, such as viruses (virome) and their interactions with bacteria (bacteriome), as well as their metabolic pathways (metabolome) in relation to aging and cognitive function, remain poorly understood. Here, we present proof-of-concept results from a pilot study using datasets (n = 176) from the Microbiome in Aging Gut and Brain (MiaGB) consortium, demonstrating that the human virome signature significantly differs across the aging continuum (60s vs. 70s vs. 80+ years of age) in older adults. We observed that the predominant virome signature was enriched with bacteriophages, which change considerably with aging continuum. Analyses of interactions between phages and the host bacteriome suggest that lytic or temperate relationships change distinctly across the aging continuum, as well as cognitive impairment. Interestingly, the phage-bacteriome-metabolome interactions develop unique patterns that are distinctly linked to aging and cognitive dysfunction in older adults. The phage-bacteriome interactions affect bacterial metabolic pathways, potentially impacting older adults' health, including the risk of cognitive decline and dementia. Further comprehension of these studies could provide opportunities to target the microbiome by developing phage therapies to improve aging and brain health in older adults.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>39676708</pmid><doi>10.1080/19490976.2024.2431648</doi><orcidid>https://orcid.org/0000-0001-8794-0748</orcidid><orcidid>https://orcid.org/0000-0003-3276-8914</orcidid><orcidid>https://orcid.org/0000-0003-4504-1597</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Aging Bacteria - classification Bacteria - genetics Bacteria - isolation & purification Bacteria - metabolism Bacteria - virology Bacteriophages - classification Bacteriophages - genetics Bacteriophages - isolation & purification cognition Cognitive Dysfunction - microbiology Cognitive Dysfunction - virology dementia Female Gastrointestinal Microbiome gut Humans Male Metabolome microbiome Middle Aged phage Pilot Projects Research Paper Virome |
| title | Abnormalities in gut virome signatures linked with cognitive impairment in older adults |
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