Detection and partial characterization of antimutagenic compounds from white shrimp (Litopenaeus vannamei) cephalothorax
Mutations are the result of effects produced by mutagenic agents, which may be responsible for the generation of chronic-degenerative diseases such as cancer. The aim of this work was to detect and characterize compounds with antimutagenic activity in white shrimp (Litopenaeus vannamei) cephalothora...
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| Veröffentlicht in: | CYTA: journal of food 2024-12, Vol.22 (1) |
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| creator | Trujillo-Ruiz, Héctor-Enrique López-Saiz, Carmen-María García-Alegría, Alejandro-Monserrat Osuna-Ruiz, Idalia Santacruz-Ortega, Hisila Del Carmen Meza-Montenegro, María-Mercedes Maldonado-Escalante, Juan-Francisco Cruz-Ramirez, Susana-Gabriela Burgos Hernández, Armando |
| description | Mutations are the result of effects produced by mutagenic agents, which may be responsible for the generation of chronic-degenerative diseases such as cancer. The aim of this work was to detect and characterize compounds with antimutagenic activity in white shrimp (Litopenaeus vannamei) cephalothorax. A serial extraction was carried out where different organic solvents, and its biological activity was evaluated. The antioxidant capacity was evaluated by DPPH and ABTS assay, where the methanol and water-soluble extracts had the highest antioxidant capacity. Antimutagenicity was evaluated by the Ames test, where the methanol-soluble extract showed the highest antimutagenic activity. The methanolic extract was fractionated by open column chromatography, the fractions obtained were determined antioxidant and antimutagenic activity and the ability to protect DNA from oxidative damage. Fraction H27 provided DNA the highest protection against the damage caused by H
2
O
2
. Partial chemical-characterization of fraction H27 suggests the presence of aromatic, hydroxylated, unsaturated compounds. |
| doi_str_mv | 10.1080/19476337.2024.2315990 |
| format | Article |
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2
O
2
. Partial chemical-characterization of fraction H27 suggests the presence of aromatic, hydroxylated, unsaturated compounds.</description><identifier>ISSN: 1947-6337</identifier><identifier>ISSN: 1947-6345</identifier><identifier>EISSN: 1947-6345</identifier><identifier>DOI: 10.1080/19476337.2024.2315990</identifier><language>eng</language><publisher>Abingdon: Taylor & Francis</publisher><subject>Ames test ; antimutagenic ; antimutagenic activity ; Antimutagenicity ; Antioxidant ; antioxidant activity ; Antioxidants ; Aromatic compounds ; bioactivity ; Biological activity ; by-product ; Cancer ; Cephalothorax ; Chemical damage ; Chromatography ; Column chromatography ; Deoxyribonucleic acid ; DNA ; DNA damage ; Hydrogen peroxide ; hydroxylation ; Litopenaeus vannamei ; Metabolism ; Methanol ; mutagens ; Organic solvents ; shrimp ; Shrimps ; water solubility</subject><ispartof>CYTA: journal of food, 2024-12, Vol.22 (1)</ispartof><rights>2024 The Author(s). Published with license by Taylor & Francis Group, LLC. 2024</rights><rights>2024 The Author(s). Published with license by Taylor & Francis Group, LLC. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c432t-ac738342642106aa50a610c7c1092bd605a9d2ecc6c8b1551826b881665bea373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/19476337.2024.2315990$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/19476337.2024.2315990$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,860,2095,27481,27903,27904,59119,59120</link.rule.ids></links><search><creatorcontrib>Trujillo-Ruiz, Héctor-Enrique</creatorcontrib><creatorcontrib>López-Saiz, Carmen-María</creatorcontrib><creatorcontrib>García-Alegría, Alejandro-Monserrat</creatorcontrib><creatorcontrib>Osuna-Ruiz, Idalia</creatorcontrib><creatorcontrib>Santacruz-Ortega, Hisila Del Carmen</creatorcontrib><creatorcontrib>Meza-Montenegro, María-Mercedes</creatorcontrib><creatorcontrib>Maldonado-Escalante, Juan-Francisco</creatorcontrib><creatorcontrib>Cruz-Ramirez, Susana-Gabriela</creatorcontrib><creatorcontrib>Burgos Hernández, Armando</creatorcontrib><title>Detection and partial characterization of antimutagenic compounds from white shrimp (Litopenaeus vannamei) cephalothorax</title><title>CYTA: journal of food</title><description>Mutations are the result of effects produced by mutagenic agents, which may be responsible for the generation of chronic-degenerative diseases such as cancer. The aim of this work was to detect and characterize compounds with antimutagenic activity in white shrimp (Litopenaeus vannamei) cephalothorax. A serial extraction was carried out where different organic solvents, and its biological activity was evaluated. The antioxidant capacity was evaluated by DPPH and ABTS assay, where the methanol and water-soluble extracts had the highest antioxidant capacity. Antimutagenicity was evaluated by the Ames test, where the methanol-soluble extract showed the highest antimutagenic activity. The methanolic extract was fractionated by open column chromatography, the fractions obtained were determined antioxidant and antimutagenic activity and the ability to protect DNA from oxidative damage. Fraction H27 provided DNA the highest protection against the damage caused by H
2
O
2
. Partial chemical-characterization of fraction H27 suggests the presence of aromatic, hydroxylated, unsaturated compounds.</description><subject>Ames test</subject><subject>antimutagenic</subject><subject>antimutagenic activity</subject><subject>Antimutagenicity</subject><subject>Antioxidant</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Aromatic compounds</subject><subject>bioactivity</subject><subject>Biological activity</subject><subject>by-product</subject><subject>Cancer</subject><subject>Cephalothorax</subject><subject>Chemical damage</subject><subject>Chromatography</subject><subject>Column chromatography</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Hydrogen peroxide</subject><subject>hydroxylation</subject><subject>Litopenaeus vannamei</subject><subject>Metabolism</subject><subject>Methanol</subject><subject>mutagens</subject><subject>Organic 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Idalia</au><au>Santacruz-Ortega, Hisila Del Carmen</au><au>Meza-Montenegro, María-Mercedes</au><au>Maldonado-Escalante, Juan-Francisco</au><au>Cruz-Ramirez, Susana-Gabriela</au><au>Burgos Hernández, Armando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection and partial characterization of antimutagenic compounds from white shrimp (Litopenaeus vannamei) cephalothorax</atitle><jtitle>CYTA: journal of food</jtitle><date>2024-12-31</date><risdate>2024</risdate><volume>22</volume><issue>1</issue><issn>1947-6337</issn><issn>1947-6345</issn><eissn>1947-6345</eissn><abstract>Mutations are the result of effects produced by mutagenic agents, which may be responsible for the generation of chronic-degenerative diseases such as cancer. The aim of this work was to detect and characterize compounds with antimutagenic activity in white shrimp (Litopenaeus vannamei) cephalothorax. A serial extraction was carried out where different organic solvents, and its biological activity was evaluated. The antioxidant capacity was evaluated by DPPH and ABTS assay, where the methanol and water-soluble extracts had the highest antioxidant capacity. Antimutagenicity was evaluated by the Ames test, where the methanol-soluble extract showed the highest antimutagenic activity. The methanolic extract was fractionated by open column chromatography, the fractions obtained were determined antioxidant and antimutagenic activity and the ability to protect DNA from oxidative damage. Fraction H27 provided DNA the highest protection against the damage caused by H
2
O
2
. Partial chemical-characterization of fraction H27 suggests the presence of aromatic, hydroxylated, unsaturated compounds.</abstract><cop>Abingdon</cop><pub>Taylor & Francis</pub><doi>10.1080/19476337.2024.2315990</doi><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Taylor & Francis Open Access Journals; Alma/SFX Local Collection |
| subjects | Ames test antimutagenic antimutagenic activity Antimutagenicity Antioxidant antioxidant activity Antioxidants Aromatic compounds bioactivity Biological activity by-product Cancer Cephalothorax Chemical damage Chromatography Column chromatography Deoxyribonucleic acid DNA DNA damage Hydrogen peroxide hydroxylation Litopenaeus vannamei Metabolism Methanol mutagens Organic solvents shrimp Shrimps water solubility |
| title | Detection and partial characterization of antimutagenic compounds from white shrimp (Litopenaeus vannamei) cephalothorax |
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