Similar molecular determinants on Rem mediate two distinct modes of inhibition of Ca V 1.2 channels

Rad/Rem/Rem2/Gem (RGK) proteins are Ras-like GTPases that potently inhibit all high-voltage-gated calcium (Ca 1/Ca 2) channels and are, thus, well-positioned to tune diverse physiological processes. Understanding how RGK proteins inhibit Ca channels is important for perspectives on their (patho)phys...

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Veröffentlicht in:	Channels (Austin, Tex.) Tex.), 2016-09, Vol.10 (5), p.379-394
Hauptverfasser:	Puckerin, Akil A, Chang, Donald D, Subramanyam, Prakash, Colecraft, Henry M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channels, L-Type - physiology Cells, Cultured Heart Ventricles - cytology HEK293 Cells Humans Male Monomeric GTP-Binding Proteins - physiology Myocytes, Cardiac - physiology Rats, Sprague-Dawley
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