Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches
Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, an...
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| Veröffentlicht in: | Cell adhesion & migration 2024-12, Vol.18 (1), p.1-17 |
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| creator | Li, Canxuan Xiao, Yunfei Kong, Jianqiu Lai, Cong Chen, Zhiliang Li, Zhuohang Xie, Weibin |
| description | Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1's involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis. |
| doi_str_mv | 10.1080/19336918.2024.2335682 |
| format | Article |
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This pan-cancer study analyzed MICAL1 across 33 cancer types using bioinformatics and experiments. Dysregulated expression, diagnostic potential, and prognostic value were assessed. Associations with tumor characteristics, immune factors, and drug sensitivity were explored. Enrichment analysis revealed MICAL1's involvement in metastasis, angiogenesis, metabolism, and immune pathways. Functional experiments demonstrated its impact on renal carcinoma cells. These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis.</description><identifier>ISSN: 1933-6918</identifier><identifier>EISSN: 1933-6926</identifier><identifier>DOI: 10.1080/19336918.2024.2335682</identifier><identifier>PMID: 38555517</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Bioinformatics ; Calponins ; Carcinoma, Renal Cell - genetics ; Cell Movement ; Computational Biology ; Cytoskeleton ; Humans ; immune pathways ; Kidney Neoplasms - genetics ; MICAL1 ; Microfilament Proteins ; Mixed Function Oxygenases ; pan-cancer ; Research Paper ; tumor immune microenvironment</subject><ispartof>Cell adhesion & migration, 2024-12, Vol.18 (1), p.1-17</ispartof><rights>2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2024</rights><rights>2024 The Author(s). 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These findings position MICAL1 as a potential biomarker and therapeutic target in specific cancers, warranting further investigation into its role in cancer pathogenesis.</description><subject>Bioinformatics</subject><subject>Calponins</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Cell Movement</subject><subject>Computational Biology</subject><subject>Cytoskeleton</subject><subject>Humans</subject><subject>immune pathways</subject><subject>Kidney Neoplasms - genetics</subject><subject>MICAL1</subject><subject>Microfilament Proteins</subject><subject>Mixed Function Oxygenases</subject><subject>pan-cancer</subject><subject>Research Paper</subject><subject>tumor immune microenvironment</subject><issn>1933-6918</issn><issn>1933-6926</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU9v1DAQxSMEoqXwEUA-csnif3HsE6CqQKUiLnC2Js5411U2DnZS6LfHYbcresEXW-M3v3mjV1WvGd0wquk7ZoRQhukNp1xuuBCN0vxJdb7Wa2W4enp6M31Wvcj5ltJGM6WeV2dCN-Ww9rzaXQ2LCz3MYdySeYckxQFJ9OTr9eXHG0bCSCYYawejw0SWvMrCOOM2wYw96UIMo49pXwAuExh7gr8nTGGP4wwDgWlKEdwO88vqmYch46vjfVH9-HT1_fJLffPt8zqqdlKLuRYShOsUBWOU7pyTyngnW4195z3znWw0MsmwQ9U46g2XaHpPwYFppBOtuKiuD9w-wq2dihNI9zZCsH8LMW0tpGJ2QNsq8F61XBjXSemazsgeJWXYtt4o5wvr_YE1Ld0ee1d2SjA8gj7-GcPObuOdZdRoyTgthLdHQoo_F8yz3YfscBhgxLhkKyjnTcu4YkXaHKQuxZwT-tMcRu0auX2I3K6R22Pkpe_NvyZPXQ8ZF8GHg-CY1K-Yht7OcD_E5FMJNhQf_5_xB_m_vaU</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>Li, Canxuan</creator><creator>Xiao, Yunfei</creator><creator>Kong, Jianqiu</creator><creator>Lai, Cong</creator><creator>Chen, Zhiliang</creator><creator>Li, Zhuohang</creator><creator>Xie, Weibin</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20241231</creationdate><title>Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches</title><author>Li, Canxuan ; Xiao, Yunfei ; Kong, Jianqiu ; Lai, Cong ; Chen, Zhiliang ; Li, Zhuohang ; Xie, Weibin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-34a3cb60a9968bcc469fc478edbff1fb458e141ebe65c0f924e9df0aca954c373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Bioinformatics</topic><topic>Calponins</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Cell Movement</topic><topic>Computational Biology</topic><topic>Cytoskeleton</topic><topic>Humans</topic><topic>immune pathways</topic><topic>Kidney Neoplasms - genetics</topic><topic>MICAL1</topic><topic>Microfilament Proteins</topic><topic>Mixed Function Oxygenases</topic><topic>pan-cancer</topic><topic>Research Paper</topic><topic>tumor immune microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Canxuan</creatorcontrib><creatorcontrib>Xiao, Yunfei</creatorcontrib><creatorcontrib>Kong, Jianqiu</creatorcontrib><creatorcontrib>Lai, Cong</creatorcontrib><creatorcontrib>Chen, Zhiliang</creatorcontrib><creatorcontrib>Li, Zhuohang</creatorcontrib><creatorcontrib>Xie, Weibin</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Cell adhesion & migration</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Canxuan</au><au>Xiao, Yunfei</au><au>Kong, Jianqiu</au><au>Lai, Cong</au><au>Chen, Zhiliang</au><au>Li, Zhuohang</au><au>Xie, Weibin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches</atitle><jtitle>Cell adhesion & migration</jtitle><addtitle>Cell Adh Migr</addtitle><date>2024-12-31</date><risdate>2024</risdate><volume>18</volume><issue>1</issue><spage>1</spage><epage>17</epage><pages>1-17</pages><issn>1933-6918</issn><eissn>1933-6926</eissn><abstract>Molecule interacting with CasL 1 (MICAL1) is a crucial protein involved in cell motility, axon guidance, cytoskeletal dynamics, and gene transcription. 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| source | MEDLINE; DOAJ Directory of Open Access Journals; Access via Taylor & Francis (Open Access Collection); EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Bioinformatics Calponins Carcinoma, Renal Cell - genetics Cell Movement Computational Biology Cytoskeleton Humans immune pathways Kidney Neoplasms - genetics MICAL1 Microfilament Proteins Mixed Function Oxygenases pan-cancer Research Paper tumor immune microenvironment |
| title | Elucidating the role of MICAL1 in pan-cancer using integrated bioinformatics and experimental approaches |
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