Role of pancreatic enzymes in the development of multiple organ failure after shock
The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancre...
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| Veröffentlicht in: | Journal of organ dysfunction 2008, Vol.4 (3), p.161-167 |
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| container_title | Journal of organ dysfunction |
| container_volume | 4 |
| creator | Malinoski, Darren J. Barrios, Cristobol Kim, Hubert D. Acosta, Jose A. Schmid-Schonbein, Geert W. Hugli, Tony E. Coimbra, Raul Hoyt, David B. |
| description | The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death. |
| doi_str_mv | 10.1080/17471060801925288 |
| format | Article |
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The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.</description><identifier>ISSN: 1747-1060</identifier><identifier>EISSN: 1747-1079</identifier><identifier>DOI: 10.1080/17471060801925288</identifier><language>eng</language><publisher>Informa UK Ltd</publisher><subject>Inflammation ; pancreas ; pancreatic duct ligation ; proteases ; serine protease inhibitors ; shock</subject><ispartof>Journal of organ dysfunction, 2008, Vol.4 (3), p.161-167</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c265t-47f8bde287633f5acc0388a0dc06a65ca3734a59208dc485f88d825ca296eb2e3</citedby><cites>FETCH-LOGICAL-c265t-47f8bde287633f5acc0388a0dc06a65ca3734a59208dc485f88d825ca296eb2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/17471060801925288$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/17471060801925288$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids></links><search><creatorcontrib>Malinoski, Darren J.</creatorcontrib><creatorcontrib>Barrios, Cristobol</creatorcontrib><creatorcontrib>Kim, Hubert D.</creatorcontrib><creatorcontrib>Acosta, Jose A.</creatorcontrib><creatorcontrib>Schmid-Schonbein, Geert W.</creatorcontrib><creatorcontrib>Hugli, Tony E.</creatorcontrib><creatorcontrib>Coimbra, Raul</creatorcontrib><creatorcontrib>Hoyt, David B.</creatorcontrib><title>Role of pancreatic enzymes in the development of multiple organ failure after shock</title><title>Journal of organ dysfunction</title><description>The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.</description><subject>Inflammation</subject><subject>pancreas</subject><subject>pancreatic duct ligation</subject><subject>proteases</subject><subject>serine protease inhibitors</subject><subject>shock</subject><issn>1747-1060</issn><issn>1747-1079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kFtLxDAQhYMouK7-AN_yB6q59JKiLyLeYEHw8lxm04ntmjYlySrrr7dlRRBhn-ZwmG-Gcwg55eyMM8XOeZEWnOWj5KXIhFJ7ZDZ5CWdFuf-rc3ZIjkJYMZZKxvIZeX5yFqkzdIBee4TYaor916bDQNuexgZpjR9o3dBhH6fFbm1jO0yQf4OeGmjt2iMFE9HT0Dj9fkwODNiAJz9zTl5vb16u75PF493D9dUi0SLPYpIWRi1rFKrIpTQZaM2kUsBqzXLIMw2ykClkpWCq1qnKjFK1EqMvyhyXAuWc8O1d7V0IHk01-LYDv6k4q6ZWqn-tjMzllml743wHn87buoqwsc4bP3bQhkruwi_-4A2CjY0Gj9XKrX0_xt3x_BvhtXrm</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Malinoski, Darren J.</creator><creator>Barrios, Cristobol</creator><creator>Kim, Hubert D.</creator><creator>Acosta, Jose A.</creator><creator>Schmid-Schonbein, Geert W.</creator><creator>Hugli, Tony E.</creator><creator>Coimbra, Raul</creator><creator>Hoyt, David B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2008</creationdate><title>Role of pancreatic enzymes in the development of multiple organ failure after shock</title><author>Malinoski, Darren J. ; Barrios, Cristobol ; Kim, Hubert D. ; Acosta, Jose A. ; Schmid-Schonbein, Geert W. ; Hugli, Tony E. ; Coimbra, Raul ; Hoyt, David B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c265t-47f8bde287633f5acc0388a0dc06a65ca3734a59208dc485f88d825ca296eb2e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Inflammation</topic><topic>pancreas</topic><topic>pancreatic duct ligation</topic><topic>proteases</topic><topic>serine protease inhibitors</topic><topic>shock</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malinoski, Darren J.</creatorcontrib><creatorcontrib>Barrios, Cristobol</creatorcontrib><creatorcontrib>Kim, Hubert D.</creatorcontrib><creatorcontrib>Acosta, Jose A.</creatorcontrib><creatorcontrib>Schmid-Schonbein, Geert W.</creatorcontrib><creatorcontrib>Hugli, Tony E.</creatorcontrib><creatorcontrib>Coimbra, Raul</creatorcontrib><creatorcontrib>Hoyt, David B.</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of organ dysfunction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malinoski, Darren J.</au><au>Barrios, Cristobol</au><au>Kim, Hubert D.</au><au>Acosta, Jose A.</au><au>Schmid-Schonbein, Geert W.</au><au>Hugli, Tony E.</au><au>Coimbra, Raul</au><au>Hoyt, David B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of pancreatic enzymes in the development of multiple organ failure after shock</atitle><jtitle>Journal of organ dysfunction</jtitle><date>2008</date><risdate>2008</risdate><volume>4</volume><issue>3</issue><spage>161</spage><epage>167</epage><pages>161-167</pages><issn>1747-1060</issn><eissn>1747-1079</eissn><abstract>The gastrointestinal tract has been implicated as one of the main organ systems involved in the initiation of the acute inflammatory response that often follows shock. The exocrine functions of the pancreas include the secretion of digestive enzymes into the duodenal lumen. These intraluminal pancreatic enzymes may play a pivotal role in the pathogenesis of multiorgan failure after shock. This article reviews the literature surrounding the hypothesis that digestive enzymes produced by the pancreas are involved in the initiation of the systemic inflammatory response after shock and, ultimately, contribute to multiorgan failure and death.</abstract><pub>Informa UK Ltd</pub><doi>10.1080/17471060801925288</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of organ dysfunction, 2008, Vol.4 (3), p.161-167 |
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| language | eng |
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| source | Taylor & Francis:Master (3349 titles) |
| subjects | Inflammation pancreas pancreatic duct ligation proteases serine protease inhibitors shock |
| title | Role of pancreatic enzymes in the development of multiple organ failure after shock |
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