Introducing a bionanocomposite (Ultrasound-assisted synthesis of Ag nanoparticles embedded Aloe vera gel) for the treatment of cervical carcinoma
Regarding applied, facile, green chemical research, a bio-inspired approach is being reported for the sonochemical synthesis of Ag nanoparticles by Aloe vera gel extract as a natural reducing/stabilising and solid support agent without using any toxic and harmful reagent. The biosynthesized Ag NPs/A...
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Veröffentlicht in: | Journal of experimental nanoscience 2022-12, Vol.17 (1), p.617-630 |
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creator | Yan, Jing Karmakar, Bikash Zaki, Mohamed Samir A. Osman, Rihab Abdalla, Asim M. Shati, Ali A. El-kott, Attalla F. Yousef, Fatimah M. Aggad, Sarah S. Batiha, Gaber El-Saber |
description | Regarding applied, facile, green chemical research, a bio-inspired approach is being reported for the sonochemical synthesis of Ag nanoparticles by Aloe vera gel extract as a natural reducing/stabilising and solid support agent without using any toxic and harmful reagent. The biosynthesized Ag NPs/A. vera gel bionanocomposite was characterised by advanced physicochemical techniques like ultraviolet-visible (UV-Vis), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), X-ray Diffraction (XRD) and elemental mapping study. It has been established that Aloe vera gel-stabilized silver nanoparticles have a spherical shape with a mean diameter of around 35-40 nm. To investigate the antioxidant potentials of Ag NPs/A. vera gel, one of the common antioxidant techniques i.e. DPPH was used. The results of DPPH test proved the excellent antioxidant properties of Ag NPs/A. vera gel in comparison to the positive control used i.e. butylated hydroxytoluene. The IC
50
of Ag NPs/A. vera gel was 42 µg/mL in the antioxidant test. Thereafter, on having a significant IC
50
value in radical scavenging assay, we extended the bio-application of the desired nanocomposite in the anticancer study. To survey the cytotoxicity and anti-human cervical carcinoma effects of Ag NPs/A. vera gel, MTT assay was used on CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines. The IC50 of the Ag NPs/A. vera gel was 16, 13, 15 and 11 µg/mL against CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines, respectively. As mentioned, the Ag NPs/A. vera gel had significant antioxidant and anti-human cervical cancer effects. After approving the above results in the clinical trial studies, the Ag NPs/A. vera gel can be used as a chemotherapeutic drug for the treatment of several types of cervical cancers. According to the above results, the significant anti-cervical cancer effects of Ag NPs/A. vera gel are confirmed. |
doi_str_mv | 10.1080/17458080.2022.2134562 |
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50
of Ag NPs/A. vera gel was 42 µg/mL in the antioxidant test. Thereafter, on having a significant IC
50
value in radical scavenging assay, we extended the bio-application of the desired nanocomposite in the anticancer study. To survey the cytotoxicity and anti-human cervical carcinoma effects of Ag NPs/A. vera gel, MTT assay was used on CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines. The IC50 of the Ag NPs/A. vera gel was 16, 13, 15 and 11 µg/mL against CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines, respectively. As mentioned, the Ag NPs/A. vera gel had significant antioxidant and anti-human cervical cancer effects. After approving the above results in the clinical trial studies, the Ag NPs/A. vera gel can be used as a chemotherapeutic drug for the treatment of several types of cervical cancers. According to the above results, the significant anti-cervical cancer effects of Ag NPs/A. vera gel are confirmed.</description><identifier>ISSN: 1745-8080</identifier><identifier>EISSN: 1745-8099</identifier><identifier>DOI: 10.1080/17458080.2022.2134562</identifier><language>eng</language><publisher>Abingdon: Taylor & Francis</publisher><subject>Ag nanocomposite ; Aloe ; antioxidant ; Antioxidants ; cancer chemotherapy ; cervical ; Cervical cancer ; Chemical synthesis ; Electron microscopy ; Microscopy ; Nanocomposites ; Nanoparticles ; Photoelectrons ; Reagents ; Scavenging ; Silver ; Spectrum analysis ; Toxicity ; X ray photoelectron spectroscopy ; X-ray spectroscopy</subject><ispartof>Journal of experimental nanoscience, 2022-12, Vol.17 (1), p.617-630</ispartof><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2022</rights><rights>2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-bd50aa375ddeefea0091cc16d9d479f8d3f94649213f1042c67bcb55ebdd8b883</citedby><cites>FETCH-LOGICAL-c451t-bd50aa375ddeefea0091cc16d9d479f8d3f94649213f1042c67bcb55ebdd8b883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/17458080.2022.2134562$$EPDF$$P50$$Ginformaworld$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/17458080.2022.2134562$$EHTML$$P50$$Ginformaworld$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,861,2096,27483,27905,27906,59122,59123</link.rule.ids></links><search><creatorcontrib>Yan, Jing</creatorcontrib><creatorcontrib>Karmakar, Bikash</creatorcontrib><creatorcontrib>Zaki, Mohamed Samir A.</creatorcontrib><creatorcontrib>Osman, Rihab</creatorcontrib><creatorcontrib>Abdalla, Asim M.</creatorcontrib><creatorcontrib>Shati, Ali A.</creatorcontrib><creatorcontrib>El-kott, Attalla F.</creatorcontrib><creatorcontrib>Yousef, Fatimah M.</creatorcontrib><creatorcontrib>Aggad, Sarah S.</creatorcontrib><creatorcontrib>Batiha, Gaber El-Saber</creatorcontrib><title>Introducing a bionanocomposite (Ultrasound-assisted synthesis of Ag nanoparticles embedded Aloe vera gel) for the treatment of cervical carcinoma</title><title>Journal of experimental nanoscience</title><description>Regarding applied, facile, green chemical research, a bio-inspired approach is being reported for the sonochemical synthesis of Ag nanoparticles by Aloe vera gel extract as a natural reducing/stabilising and solid support agent without using any toxic and harmful reagent. The biosynthesized Ag NPs/A. vera gel bionanocomposite was characterised by advanced physicochemical techniques like ultraviolet-visible (UV-Vis), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), X-ray Diffraction (XRD) and elemental mapping study. It has been established that Aloe vera gel-stabilized silver nanoparticles have a spherical shape with a mean diameter of around 35-40 nm. To investigate the antioxidant potentials of Ag NPs/A. vera gel, one of the common antioxidant techniques i.e. DPPH was used. The results of DPPH test proved the excellent antioxidant properties of Ag NPs/A. vera gel in comparison to the positive control used i.e. butylated hydroxytoluene. The IC
50
of Ag NPs/A. vera gel was 42 µg/mL in the antioxidant test. Thereafter, on having a significant IC
50
value in radical scavenging assay, we extended the bio-application of the desired nanocomposite in the anticancer study. To survey the cytotoxicity and anti-human cervical carcinoma effects of Ag NPs/A. vera gel, MTT assay was used on CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines. The IC50 of the Ag NPs/A. vera gel was 16, 13, 15 and 11 µg/mL against CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines, respectively. As mentioned, the Ag NPs/A. vera gel had significant antioxidant and anti-human cervical cancer effects. After approving the above results in the clinical trial studies, the Ag NPs/A. vera gel can be used as a chemotherapeutic drug for the treatment of several types of cervical cancers. According to the above results, the significant anti-cervical cancer effects of Ag NPs/A. vera gel are confirmed.</description><subject>Ag nanocomposite</subject><subject>Aloe</subject><subject>antioxidant</subject><subject>Antioxidants</subject><subject>cancer chemotherapy</subject><subject>cervical</subject><subject>Cervical cancer</subject><subject>Chemical synthesis</subject><subject>Electron microscopy</subject><subject>Microscopy</subject><subject>Nanocomposites</subject><subject>Nanoparticles</subject><subject>Photoelectrons</subject><subject>Reagents</subject><subject>Scavenging</subject><subject>Silver</subject><subject>Spectrum analysis</subject><subject>Toxicity</subject><subject>X ray photoelectron spectroscopy</subject><subject>X-ray spectroscopy</subject><issn>1745-8080</issn><issn>1745-8099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>DOA</sourceid><recordid>eNp9UctuEzEUHSGQKIVPQLLEBhYT7Bk749kRVYVGqsSGrq1r-zo4mrGD7RTlM_hjPCTtktV96JxzH6dp3jO6YlTSz2zgQtZk1dGuW3Ws52LdvWiuln4r6Ti-fM4lfd28yXlPKedSDFfNn20oKdqj8WFHgGgfA4Ro4nyI2RckHx-mkiDHY7At5OxzQUvyKZSfWAsSHdnsyEI5QCreTJgJzhqtrbDNFJE8YgKyw-kTcTGRSiMlIZQZQ1nYBtOjNzARA6nuEGd427xyMGV8d4nXzcPX2x83d-3992_bm819a7hgpdVWUIB-EHUUOgRKR2YMW9vR8mF00vZu5Gs-1nc4Rnln1oM2WgjU1kotZX_dbM-6NsJeHZKfIZ1UBK_-NWLaqctJau2ENIJqYAI5SqaRQzdozoBxa4FWrQ9nrUOKv46Yi9rHYwp1fdUNXNJe1FBR4owyKeac0D1PZVQtTqonJ9XipLo4WXlfzjwf6g9n-B3TZFWB0xSTSxCMz6r_v8RfkbyoPQ</recordid><startdate>20221231</startdate><enddate>20221231</enddate><creator>Yan, Jing</creator><creator>Karmakar, Bikash</creator><creator>Zaki, Mohamed Samir A.</creator><creator>Osman, Rihab</creator><creator>Abdalla, Asim M.</creator><creator>Shati, Ali A.</creator><creator>El-kott, Attalla F.</creator><creator>Yousef, Fatimah M.</creator><creator>Aggad, Sarah S.</creator><creator>Batiha, Gaber El-Saber</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TC</scope><scope>7XB</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>JG9</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>DOA</scope></search><sort><creationdate>20221231</creationdate><title>Introducing a bionanocomposite (Ultrasound-assisted synthesis of Ag nanoparticles embedded Aloe vera gel) for the treatment of cervical carcinoma</title><author>Yan, Jing ; Karmakar, Bikash ; Zaki, Mohamed Samir A. ; Osman, Rihab ; Abdalla, Asim M. ; Shati, Ali A. ; El-kott, Attalla F. ; Yousef, Fatimah M. ; Aggad, Sarah S. ; Batiha, Gaber El-Saber</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-bd50aa375ddeefea0091cc16d9d479f8d3f94649213f1042c67bcb55ebdd8b883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Ag nanocomposite</topic><topic>Aloe</topic><topic>antioxidant</topic><topic>Antioxidants</topic><topic>cancer chemotherapy</topic><topic>cervical</topic><topic>Cervical cancer</topic><topic>Chemical synthesis</topic><topic>Electron microscopy</topic><topic>Microscopy</topic><topic>Nanocomposites</topic><topic>Nanoparticles</topic><topic>Photoelectrons</topic><topic>Reagents</topic><topic>Scavenging</topic><topic>Silver</topic><topic>Spectrum analysis</topic><topic>Toxicity</topic><topic>X ray photoelectron spectroscopy</topic><topic>X-ray spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yan, Jing</creatorcontrib><creatorcontrib>Karmakar, Bikash</creatorcontrib><creatorcontrib>Zaki, Mohamed Samir A.</creatorcontrib><creatorcontrib>Osman, Rihab</creatorcontrib><creatorcontrib>Abdalla, Asim M.</creatorcontrib><creatorcontrib>Shati, Ali A.</creatorcontrib><creatorcontrib>El-kott, Attalla F.</creatorcontrib><creatorcontrib>Yousef, Fatimah M.</creatorcontrib><creatorcontrib>Aggad, Sarah S.</creatorcontrib><creatorcontrib>Batiha, Gaber El-Saber</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Mechanical Engineering Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Materials Research Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of experimental nanoscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yan, Jing</au><au>Karmakar, Bikash</au><au>Zaki, Mohamed Samir A.</au><au>Osman, Rihab</au><au>Abdalla, Asim M.</au><au>Shati, Ali A.</au><au>El-kott, Attalla F.</au><au>Yousef, Fatimah M.</au><au>Aggad, Sarah S.</au><au>Batiha, Gaber El-Saber</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Introducing a bionanocomposite (Ultrasound-assisted synthesis of Ag nanoparticles embedded Aloe vera gel) for the treatment of cervical carcinoma</atitle><jtitle>Journal of experimental nanoscience</jtitle><date>2022-12-31</date><risdate>2022</risdate><volume>17</volume><issue>1</issue><spage>617</spage><epage>630</epage><pages>617-630</pages><issn>1745-8080</issn><eissn>1745-8099</eissn><abstract>Regarding applied, facile, green chemical research, a bio-inspired approach is being reported for the sonochemical synthesis of Ag nanoparticles by Aloe vera gel extract as a natural reducing/stabilising and solid support agent without using any toxic and harmful reagent. The biosynthesized Ag NPs/A. vera gel bionanocomposite was characterised by advanced physicochemical techniques like ultraviolet-visible (UV-Vis), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Energy Dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), X-ray Diffraction (XRD) and elemental mapping study. It has been established that Aloe vera gel-stabilized silver nanoparticles have a spherical shape with a mean diameter of around 35-40 nm. To investigate the antioxidant potentials of Ag NPs/A. vera gel, one of the common antioxidant techniques i.e. DPPH was used. The results of DPPH test proved the excellent antioxidant properties of Ag NPs/A. vera gel in comparison to the positive control used i.e. butylated hydroxytoluene. The IC
50
of Ag NPs/A. vera gel was 42 µg/mL in the antioxidant test. Thereafter, on having a significant IC
50
value in radical scavenging assay, we extended the bio-application of the desired nanocomposite in the anticancer study. To survey the cytotoxicity and anti-human cervical carcinoma effects of Ag NPs/A. vera gel, MTT assay was used on CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines. The IC50 of the Ag NPs/A. vera gel was 16, 13, 15 and 11 µg/mL against CC1-PI19, SiHa, HeLa and HNCF-PI52 cell lines, respectively. As mentioned, the Ag NPs/A. vera gel had significant antioxidant and anti-human cervical cancer effects. After approving the above results in the clinical trial studies, the Ag NPs/A. vera gel can be used as a chemotherapeutic drug for the treatment of several types of cervical cancers. According to the above results, the significant anti-cervical cancer effects of Ag NPs/A. vera gel are confirmed.</abstract><cop>Abingdon</cop><pub>Taylor & Francis</pub><doi>10.1080/17458080.2022.2134562</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Ag nanocomposite Aloe antioxidant Antioxidants cancer chemotherapy cervical Cervical cancer Chemical synthesis Electron microscopy Microscopy Nanocomposites Nanoparticles Photoelectrons Reagents Scavenging Silver Spectrum analysis Toxicity X ray photoelectron spectroscopy X-ray spectroscopy |
title | Introducing a bionanocomposite (Ultrasound-assisted synthesis of Ag nanoparticles embedded Aloe vera gel) for the treatment of cervical carcinoma |
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