Target site antibiotic concentrations in orthopedic/trauma extremity surgery: is prophylactic cefazolin adequately dosed? A systematic review and meta-analysis

Background and purpose - The incidence of surgical site infections (SSIs) in trauma/orthopedic surgery varies between different body parts. Antibiotic prophylaxis (e.g., with cefazolin) lowers infection rates in closed fracture surgery and in primary arthroplasty. For prophylactic antibiotics to pre...

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Veröffentlicht in:	Acta orthopaedica 2019-03, Vol.90 (2), p.97-104
Hauptverfasser:	Sanders, Fay R K, Goslings, J Carel, Mathôt, Ron A A, Schepers, Tim
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic Prophylaxis - methods Biological Availability Cefazolin - pharmacology Drug Dosage Calculations Extremities - injuries Extremities - surgery Humans Orthopedic Procedures - adverse effects Orthopedic Procedures - methods Surgical Wound Infection - prevention & control Treatment Outcome
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