Effects of β-conglycinin on growth performance, immunoglobulins and intestinal mucosal morphology in piglets
One of the main causes of allergic reactions in young animals is β -conglycinin, an antigenic glycoprotein found in soya beans. Therefore, the objective of the study was to investigate the effects of a prior immunisation with β -conglycinin on growth performance, serum immunoglobulin levels and inte...
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| Veröffentlicht in: | Archives of animal nutrition 2014-01, Vol.68 (3), p.186-195 |
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| creator | Wang, Xichun Geng, Fangfang Wu, Jinjie Kou, Yanan Xu, Shuliang Sun, Zhikuo Feng, Shibin Ma, Liangyou Luo, Ying |
| description | One of the main causes of allergic reactions in young animals is β -conglycinin, an antigenic glycoprotein found in soya beans. Therefore, the objective of the study was to investigate the effects of a prior immunisation with β -conglycinin on growth performance, serum immunoglobulin levels and intestinal histology in piglets. Forty piglets (7 d of age) were randomly divided into four groups of ten piglets each. Piglets of Groups Im and Im+S were immunised twice by hypodermic injection with β -conglycinin at 500 μg/kg body weight (BW) at day 7 and 21 of age. At day 23, Groups Im+S and S were intramuscularly injected with 5000 μg β -conglycinin per kg BW. The piglets of Group C received a physiological saline solution by hypodermic injection. All piglets were weaned at the age of 23 d and blood samples were taken on days 7, 21 and 35. At the end of the trial, five piglets per group were slaughtered and the intestine was collected for evaluating mucosal histology. Compared to Group C, in Group S the average daily gain (ADG), feed intake and gain:feed ratio were decreased (p |
| doi_str_mv | 10.1080/1745039X.2014.919733 |
| format | Article |
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Therefore, the objective of the study was to investigate the effects of a prior immunisation with β -conglycinin on growth performance, serum immunoglobulin levels and intestinal histology in piglets. Forty piglets (7 d of age) were randomly divided into four groups of ten piglets each. Piglets of Groups Im and Im+S were immunised twice by hypodermic injection with β -conglycinin at 500 μg/kg body weight (BW) at day 7 and 21 of age. At day 23, Groups Im+S and S were intramuscularly injected with 5000 μg β -conglycinin per kg BW. The piglets of Group C received a physiological saline solution by hypodermic injection. All piglets were weaned at the age of 23 d and blood samples were taken on days 7, 21 and 35. At the end of the trial, five piglets per group were slaughtered and the intestine was collected for evaluating mucosal histology. Compared to Group C, in Group S the average daily gain (ADG), feed intake and gain:feed ratio were decreased (p < 0.01), and serum levels of IgG and IgE were increased (p < 0.01). Furthermore, in this group the structure of duodenal and jejunal mucosa was severely damaged. But in Groups Im and Im+S the ADG was increased (p < 0.05), serum IgE levels were decreased (p < 0.01) and the intestinal mucosa was not damaged. The results suggest that prior immunisation with β -conglycinin can increase ADG and serum IgG levels and decrease serum IgE levels. Therefore, this method is also potentially able to protect the structural integrity of the intestinal mucosal epithelia and alleviate allergic reactions in piglets.</description><identifier>ISSN: 1477-2817</identifier><identifier>ISSN: 1745-039X</identifier><identifier>EISSN: 1477-2817</identifier><identifier>DOI: 10.1080/1745039X.2014.919733</identifier><identifier>PMID: 24870267</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>allergens ; Animal Feed - analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Antigens, Plant - immunology ; average daily gain ; beta-conglycinin ; blood serum ; body weight ; Diet - veterinary ; feed intake ; Food Hypersensitivity - prevention & control ; Food Hypersensitivity - veterinary ; Globulins - immunology ; Glycine max - immunology ; glycoproteins ; growth performance ; histology ; Immunization ; Immunization Schedule ; immunoglobulin E ; immunoglobulin G ; immunoglobulins ; Immunoglobulins - blood ; intestinal mucosa ; Intestinal Mucosa - drug effects ; jejunum ; mucosa ; piglets ; Seed Storage Proteins - immunology ; sodium chloride ; soya bean protein ; Soybean Proteins - immunology ; soybeans ; Swine - growth & development ; Swine - physiology ; Vaccines - immunology</subject><ispartof>Archives of animal nutrition, 2014-01, Vol.68 (3), p.186-195</ispartof><rights>2014 Taylor & Francis 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-d376ac567f2127cefe136f4223620f7f02488419196d24401b92280c70b5c9ca3</citedby><cites>FETCH-LOGICAL-c420t-d376ac567f2127cefe136f4223620f7f02488419196d24401b92280c70b5c9ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/1745039X.2014.919733$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/1745039X.2014.919733$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24870267$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xichun</creatorcontrib><creatorcontrib>Geng, Fangfang</creatorcontrib><creatorcontrib>Wu, Jinjie</creatorcontrib><creatorcontrib>Kou, Yanan</creatorcontrib><creatorcontrib>Xu, Shuliang</creatorcontrib><creatorcontrib>Sun, Zhikuo</creatorcontrib><creatorcontrib>Feng, Shibin</creatorcontrib><creatorcontrib>Ma, Liangyou</creatorcontrib><creatorcontrib>Luo, Ying</creatorcontrib><title>Effects of β-conglycinin on growth performance, immunoglobulins and intestinal mucosal morphology in piglets</title><title>Archives of animal nutrition</title><addtitle>Arch Anim Nutr</addtitle><description>One of the main causes of allergic reactions in young animals is β -conglycinin, an antigenic glycoprotein found in soya beans. Therefore, the objective of the study was to investigate the effects of a prior immunisation with β -conglycinin on growth performance, serum immunoglobulin levels and intestinal histology in piglets. Forty piglets (7 d of age) were randomly divided into four groups of ten piglets each. Piglets of Groups Im and Im+S were immunised twice by hypodermic injection with β -conglycinin at 500 μg/kg body weight (BW) at day 7 and 21 of age. At day 23, Groups Im+S and S were intramuscularly injected with 5000 μg β -conglycinin per kg BW. The piglets of Group C received a physiological saline solution by hypodermic injection. All piglets were weaned at the age of 23 d and blood samples were taken on days 7, 21 and 35. At the end of the trial, five piglets per group were slaughtered and the intestine was collected for evaluating mucosal histology. Compared to Group C, in Group S the average daily gain (ADG), feed intake and gain:feed ratio were decreased (p < 0.01), and serum levels of IgG and IgE were increased (p < 0.01). Furthermore, in this group the structure of duodenal and jejunal mucosa was severely damaged. But in Groups Im and Im+S the ADG was increased (p < 0.05), serum IgE levels were decreased (p < 0.01) and the intestinal mucosa was not damaged. The results suggest that prior immunisation with β -conglycinin can increase ADG and serum IgG levels and decrease serum IgE levels. Therefore, this method is also potentially able to protect the structural integrity of the intestinal mucosal epithelia and alleviate allergic reactions in piglets.</description><subject>allergens</subject><subject>Animal Feed - analysis</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Antigens, Plant - immunology</subject><subject>average daily gain</subject><subject>beta-conglycinin</subject><subject>blood serum</subject><subject>body weight</subject><subject>Diet - veterinary</subject><subject>feed intake</subject><subject>Food Hypersensitivity - prevention & control</subject><subject>Food Hypersensitivity - veterinary</subject><subject>Globulins - immunology</subject><subject>Glycine max - immunology</subject><subject>glycoproteins</subject><subject>growth performance</subject><subject>histology</subject><subject>Immunization</subject><subject>Immunization Schedule</subject><subject>immunoglobulin E</subject><subject>immunoglobulin G</subject><subject>immunoglobulins</subject><subject>Immunoglobulins - blood</subject><subject>intestinal mucosa</subject><subject>Intestinal Mucosa - drug effects</subject><subject>jejunum</subject><subject>mucosa</subject><subject>piglets</subject><subject>Seed Storage Proteins - immunology</subject><subject>sodium chloride</subject><subject>soya bean protein</subject><subject>Soybean Proteins - immunology</subject><subject>soybeans</subject><subject>Swine - growth & development</subject><subject>Swine - physiology</subject><subject>Vaccines - immunology</subject><issn>1477-2817</issn><issn>1745-039X</issn><issn>1477-2817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkctu1TAQhi0EoqXwBgi8ZEEO40vsZIWqqlykSiygEjvLx7FTI8cOdqLqvBYPwjPhQ1rEDlYz0nz_3H6EnhPYEejgDZG8BdZ_3VEgfNeTXjL2AJ0SLmVDOyIf_pWfoCelfANgjAn5GJ1Q3kmgQp6i6dI5a5aCk8M_fzQmxTEcjI8-4hTxmNPtcoNnm13Kk47GvsZ-mtaYxpD2a_CxYB0H7ONiy-KjDnhaTSrHmPJ8k0IaD7WKZz8Gu5Sn6JHTodhnd_EMXb-7_HLxobn69P7jxflVYziFpRmYFNq0QjpKqDTWWcKE45QyQcFJB3X_jpN6sxgo50D2PaUdGAn71vRGszP0aus75_R9raupyRdjQ9DRprUo0nKgjFJB_wNl0Lec9W1F-YaanErJ1qk5-0nngyKgjp6oe0_U0RO1eVJlL-4mrPvJDn9E9yZU4O0G-Pj7zbcph0Et-hBSdrl-3RfF_jHi5dbB6aT0mKvg-nMFBACBlnc9-wXqK6Vz</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Wang, Xichun</creator><creator>Geng, Fangfang</creator><creator>Wu, Jinjie</creator><creator>Kou, Yanan</creator><creator>Xu, Shuliang</creator><creator>Sun, Zhikuo</creator><creator>Feng, Shibin</creator><creator>Ma, Liangyou</creator><creator>Luo, Ying</creator><general>Taylor & Francis</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20140101</creationdate><title>Effects of β-conglycinin on growth performance, immunoglobulins and intestinal mucosal morphology in piglets</title><author>Wang, Xichun ; Geng, Fangfang ; Wu, Jinjie ; Kou, Yanan ; Xu, Shuliang ; Sun, Zhikuo ; Feng, Shibin ; Ma, Liangyou ; Luo, Ying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-d376ac567f2127cefe136f4223620f7f02488419196d24401b92280c70b5c9ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>allergens</topic><topic>Animal Feed - analysis</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Antigens, Plant - immunology</topic><topic>average daily gain</topic><topic>beta-conglycinin</topic><topic>blood serum</topic><topic>body weight</topic><topic>Diet - veterinary</topic><topic>feed intake</topic><topic>Food Hypersensitivity - prevention & control</topic><topic>Food Hypersensitivity - veterinary</topic><topic>Globulins - immunology</topic><topic>Glycine max - immunology</topic><topic>glycoproteins</topic><topic>growth performance</topic><topic>histology</topic><topic>Immunization</topic><topic>Immunization Schedule</topic><topic>immunoglobulin E</topic><topic>immunoglobulin G</topic><topic>immunoglobulins</topic><topic>Immunoglobulins - blood</topic><topic>intestinal mucosa</topic><topic>Intestinal Mucosa - drug effects</topic><topic>jejunum</topic><topic>mucosa</topic><topic>piglets</topic><topic>Seed Storage Proteins - immunology</topic><topic>sodium chloride</topic><topic>soya bean protein</topic><topic>Soybean Proteins - immunology</topic><topic>soybeans</topic><topic>Swine - growth & development</topic><topic>Swine - physiology</topic><topic>Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xichun</creatorcontrib><creatorcontrib>Geng, Fangfang</creatorcontrib><creatorcontrib>Wu, Jinjie</creatorcontrib><creatorcontrib>Kou, Yanan</creatorcontrib><creatorcontrib>Xu, Shuliang</creatorcontrib><creatorcontrib>Sun, Zhikuo</creatorcontrib><creatorcontrib>Feng, Shibin</creatorcontrib><creatorcontrib>Ma, Liangyou</creatorcontrib><creatorcontrib>Luo, Ying</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Archives of animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xichun</au><au>Geng, Fangfang</au><au>Wu, Jinjie</au><au>Kou, Yanan</au><au>Xu, Shuliang</au><au>Sun, Zhikuo</au><au>Feng, Shibin</au><au>Ma, Liangyou</au><au>Luo, Ying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of β-conglycinin on growth performance, immunoglobulins and intestinal mucosal morphology in piglets</atitle><jtitle>Archives of animal nutrition</jtitle><addtitle>Arch Anim Nutr</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>68</volume><issue>3</issue><spage>186</spage><epage>195</epage><pages>186-195</pages><issn>1477-2817</issn><issn>1745-039X</issn><eissn>1477-2817</eissn><abstract>One of the main causes of allergic reactions in young animals is β -conglycinin, an antigenic glycoprotein found in soya beans. Therefore, the objective of the study was to investigate the effects of a prior immunisation with β -conglycinin on growth performance, serum immunoglobulin levels and intestinal histology in piglets. Forty piglets (7 d of age) were randomly divided into four groups of ten piglets each. Piglets of Groups Im and Im+S were immunised twice by hypodermic injection with β -conglycinin at 500 μg/kg body weight (BW) at day 7 and 21 of age. At day 23, Groups Im+S and S were intramuscularly injected with 5000 μg β -conglycinin per kg BW. The piglets of Group C received a physiological saline solution by hypodermic injection. All piglets were weaned at the age of 23 d and blood samples were taken on days 7, 21 and 35. At the end of the trial, five piglets per group were slaughtered and the intestine was collected for evaluating mucosal histology. Compared to Group C, in Group S the average daily gain (ADG), feed intake and gain:feed ratio were decreased (p < 0.01), and serum levels of IgG and IgE were increased (p < 0.01). Furthermore, in this group the structure of duodenal and jejunal mucosa was severely damaged. But in Groups Im and Im+S the ADG was increased (p < 0.05), serum IgE levels were decreased (p < 0.01) and the intestinal mucosa was not damaged. The results suggest that prior immunisation with β -conglycinin can increase ADG and serum IgG levels and decrease serum IgE levels. Therefore, this method is also potentially able to protect the structural integrity of the intestinal mucosal epithelia and alleviate allergic reactions in piglets.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>24870267</pmid><doi>10.1080/1745039X.2014.919733</doi><tpages>10</tpages></addata></record> |
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| subjects | allergens Animal Feed - analysis Animal Nutritional Physiological Phenomena Animals Antigens, Plant - immunology average daily gain beta-conglycinin blood serum body weight Diet - veterinary feed intake Food Hypersensitivity - prevention & control Food Hypersensitivity - veterinary Globulins - immunology Glycine max - immunology glycoproteins growth performance histology Immunization Immunization Schedule immunoglobulin E immunoglobulin G immunoglobulins Immunoglobulins - blood intestinal mucosa Intestinal Mucosa - drug effects jejunum mucosa piglets Seed Storage Proteins - immunology sodium chloride soya bean protein Soybean Proteins - immunology soybeans Swine - growth & development Swine - physiology Vaccines - immunology |
| title | Effects of β-conglycinin on growth performance, immunoglobulins and intestinal mucosal morphology in piglets |
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