Battle of epigenetic proportions: comparing Illumina's EPIC methylation microarrays and TruSeq targeted bisulfite sequencing

DNA methylation microarrays have been the platform of choice for epigenome-wide association studies in epidemiology, but declining costs have rendered targeted bisulphite sequencing a feasible alternative. Nonetheless, the literature for researchers seeking guidance on which platform to choose is sp...

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Veröffentlicht in:	Epigenetics 2020-02, Vol.15 (1-2), p.174-182
Hauptverfasser:	Heiss, Jonathan A., Brennan, Kasey J., Baccarelli, Andrea A., Téllez-Rojo, Martha M., Estrada-Gutiérrez, Guadalupe, Wright, Robert O., Just, Allan C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult bisulphite sequencing Cohort Studies comparison of experimental platforms DNA Methylation Epigenome Epigenomics - methods Epigenomics - standards EWAS Female Genome-Wide Association Study - methods Genome-Wide Association Study - standards Humans Infant, Newborn microarray Research Paper Sensitivity and Specificity Sequence Analysis, DNA - methods Sequence Analysis, DNA - standards
Online-Zugang:	Volltext
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