Histone variant macroH2A1 rewires carbohydrate and lipid metabolism of hepatocellular carcinoma cells towards cancer stem cells

Hepatocellular carcinomas (HCCs) contain a sub-population of cancer stem cells (CSCs) that are responsible for tumor relapse, metastasis, and chemoresistance. We recently showed that loss of macroH2A1, a variant of the histone H2A and an epigenetic regulator of stem-cell function, in HCC leads to CS...

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Veröffentlicht in:	Epigenetics 2018-08, Vol.13 (8), p.829-845
Hauptverfasser:	Lo Re, Oriana, Douet, Julien, Buschbeck, Marcus, Fusilli, Caterina, Pazienza, Valerio, Panebianco, Concetta, Castracani, Carlo Castruccio, Mazza, Tommaso, Li Volti, Giovanni, Vinciguerra, Manlio
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer stem cells hepatocellular carcinoma Histone variants Research Paper
Online-Zugang:	Volltext
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