Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs

Mitochondria-associated membranes (MAMs) are essential communication subdomains of the endoplasmic reticulum (ER) that interact with mitochondria. We previously demonstrated that, upon macroautophagy/autophagy induction, AMBRA1 is recruited to the BECN1 complex and relocalizes to MAMs, where it regu...

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Veröffentlicht in:	Autophagy 2021-09, Vol.17 (9), p.2528-2548
Hauptverfasser:	Manganelli, Valeria, Matarrese, Paola, Antonioli, Manuela, Gambardella, Lucrezia, Vescovo, Tiziana, Gretzmeier, Christine, Longo, Agostina, Capozzi, Antonella, Recalchi, Serena, Riitano, Gloria, Misasi, Roberta, Dengjel, Joern, Malorni, Walter, Fimia, Gian Maria, Sorice, Maurizio, Garofalo, Tina
Format:	Artikel
Sprache:	eng
Schlagworte:	AMBRA1 Autophagosomes - metabolism autophagy Autophagy - genetics ERLIN1 lipid rafts Lipids Mitochondria - metabolism mitochondria associated membranes Mitochondrial Membranes - metabolism Research Paper
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