Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity

Saturated fatty acid (SFA)-induced lipotoxicity is caused by the accumulation of reactive oxygen species (ROS), which is associated with damaged mitochondria. Moreover, lipotoxicity is crucial for the progression of nonalcoholic steatohepatitis (NASH). Autophagy is required for the clearance of prot...

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Veröffentlicht in:	Autophagy 2020-01, Vol.16 (1), p.86-105
Hauptverfasser:	Park, Jeong Su, Lee, Da Hyun, Lee, Yu Seol, Oh, Eunji, Bae, Kwang-Hee, Oh, Kyoung-Jin, Kim, Hyunmi, Bae, Soo Han
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Autophagy - genetics Autophagy - physiology Autophagy-Related Protein-1 Homolog - metabolism Cytoprotection - physiology Humans Intracellular Signaling Peptides and Proteins - metabolism KEAP1 (kelch like ECH-associated protein 1) Kelch-Like ECH-Associated Protein 1 - metabolism lipotoxicity NASH NF-E2-Related Factor 2 - metabolism Research Paper Sequestosome-1 Protein - metabolism SQSTM1/p62 (sequestosome 1) ULK1 (unc-51-like autophagy activating kinase 1)
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