Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells

Macroautophagy/autophagy is a cellular degradation pathway that delivers cytoplasmic material to lysosomes via double-membrane organelles called autophagosomes. Lipidation of ubiquitin-like LC3/GABARAP proteins on the autophagosome membrane is important for autophagy. The cysteine protease ATG4 exec...

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Veröffentlicht in:	Autophagy 2019-06, Vol.15 (6), p.976-997
Hauptverfasser:	Agrotis, Alexander, Pengo, Niccolo, Burden, Jemima J., Ketteler, Robin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Atg8 Autophagosomes - metabolism Autophagosomes - ultrastructure Autophagy - physiology Autophagy-Related Proteins - genetics Autophagy-Related Proteins - metabolism Caspase 3 - metabolism CLEM CRISPR Cysteine Endopeptidases - genetics Cysteine Endopeptidases - metabolism delipidation GABARAPL2 HEK293 Cells HeLa Cells Humans knockout Lysosomes - metabolism Lysosomes - ultrastructure Membrane Fusion - genetics Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Protein Isoforms Research Paper Sequestosome-1 Protein - metabolism
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