Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells

Macroautophagy/autophagy inhibition is a novel anticancer therapeutic strategy, especially for tumors driven by mutant RAS. Here, we demonstrate that autophagy inhibition in RAS-mutated cells induces epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor invasion. This is a...

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Veröffentlicht in:	Autophagy 2019-05, Vol.15 (5), p.886-899
Hauptverfasser:	Wang, Yihua, Xiong, Hua, Liu, Dian, Hill, Charlotte, Ertay, Ayse, Li, Juanjuan, Zou, Yanmei, Miller, Paul, White, Eileen, Downward, Julian, Goldin, Robert D, Yuan, Xianglin, Lu, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Autophagy Autophagy - drug effects Autophagy - genetics Autophagy-Related Protein 5 - antagonists & inhibitors Autophagy-Related Protein 5 - genetics Autophagy-Related Proteins - antagonists & inhibitors Autophagy-Related Proteins - genetics Cell Line, Tumor EMT Epithelial-Mesenchymal Transition - drug effects Epithelial-Mesenchymal Transition - physiology Genes, ras - genetics HCT116 Cells Humans Mutation Neoplasm Invasiveness Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology NFKB/NF-0κB RAS Research Paper - Translational RNA, Small Interfering - pharmacology Sequestosome-1 Protein - antagonists & inhibitors Sequestosome-1 Protein - genetics SQSTM1/p62 Transcription Factor RelA - antagonists & inhibitors Transcription Factor RelA - genetics Ubiquitin-Conjugating Enzymes - antagonists & inhibitors Ubiquitin-Conjugating Enzymes - genetics Up-Regulation - drug effects
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