Long non-coding RNA NEAT1_1 ameliorates TDP-43 toxicity in in vivo models of TDP-43 proteinopathy

Pathological changes involving TDP-43 protein ('TDP-43 proteinopathy') are typical for several neurodegenerative diseases, including frontotemporal lobar degeneration (FTLD). FTLD-TDP cases are characterized by increased binding of TDP-43 to an abundant lncRNA, NEAT1, in the cortex. Howeve...

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Veröffentlicht in:	RNA biology 2021-11, Vol.18 (11), p.1546-1554
Hauptverfasser:	Matsukawa, Koji, Kukharsky, Michail S., Park, Sei-Kyoung, Park, Sangeun, Watanabe, Naruaki, Iwatsubo, Takeshi, Hashimoto, Tadafumi, Liebman, Susan W., Shelkovnikova, Tatyana A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ALS Alzheimer's disease Amyotrophic Lateral Sclerosis - etiology Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Amyotrophic Lateral Sclerosis - prevention & control Animals Brain - metabolism Brain - pathology Brief Communication Disease Models, Animal DNA-Binding Proteins - toxicity drosophila Drosophila melanogaster frontotemporal dementia Frontotemporal Dementia - etiology Frontotemporal Dementia - metabolism Frontotemporal Dementia - pathology Frontotemporal Dementia - prevention & control FTLD FUS Humans Mice Mice, Inbred C57BL Mice, Transgenic NEAT1 Neuroblastoma - etiology Neuroblastoma - metabolism Neuroblastoma - pathology Neuroblastoma - prevention & control neurodegeneration proteinopathy Rapid Communication RNA, Long Noncoding - administration & dosage RNA, Long Noncoding - genetics Saccharomyces cerevisiae TDP-43 TDP-43 Proteinopathies - etiology TDP-43 Proteinopathies - metabolism TDP-43 Proteinopathies - pathology TDP-43 Proteinopathies - prevention & control yeast
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