SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer
Small nucleolar RNA host gene 7 (SNHG7) is a newly recognized oncogenic Long non-coding RNA (lncRNA) in most human cancers. In gastric cancer, SNHG7 has been suggested to enhance cell proliferation and suppressed apoptosis through down-regulating P15 and P16 expression, but the effect of SNHG7 on ga...
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| Veröffentlicht in: | Cell cycle (Georgetown, Tex.) Tex.), 2020-01, Vol.19 (1), p.142-152 |
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| creator | Zhang, Yangmei Yuan, Yuan Zhang, Youwei Cheng, Long Zhou, Xichang Chen, Kai |
| description | Small nucleolar RNA host gene 7 (SNHG7) is a newly recognized oncogenic Long non-coding RNA (lncRNA) in most human cancers. In gastric cancer, SNHG7 has been suggested to enhance cell proliferation and suppressed apoptosis through down-regulating P15 and P16 expression, but the effect of SNHG7 on gastric cancer cell migration and invasion was still unknown. In our study, we aimed to estimate the relationship between SNHG7 expression and clinical and pathological characteristics, and explore the effect of SNHG7 on gastric cancer cell migration and invasion. In our study, the levels of SNHG7 expression in gastric cancer tissues and cell lines were severally higher than in normal adjacent tissues and gastric mucosal epithelial cells. Moreover, high SNHG7 expression was positively correlated with TNM stage, depth of invasion, lymph-node metastasis and distant metastasis in gastric cancer patients. Furthermore, the multivariate Cox proportional hazard analysis further showed high SNHG7 expression was an independent poor prognostic factor for overall survival in gastric cancer patients. The studies in vitro revealed that SNHG7 directly binds to miR-34a and negatively regulates miR-34a expression, and SNHG7 enhances gastric cancer cell migration and invasion through suppressing miR-34a-Snail-EMT axis. In conclusion, SNHG7 functions as oncogenic lncRNA in gastric cancer and may be a potential therapeutic target for gastric cancer patients.
Abbreviations: lncRNA: Long non-coding RNA; SNHG7: Small nucleolar RNA host gene 7; EMT: Epithelial mesenchymal transition; TNM: Tumor-Lymph Node-Metastasis. |
| doi_str_mv | 10.1080/15384101.2019.1699753 |
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Abbreviations: lncRNA: Long non-coding RNA; SNHG7: Small nucleolar RNA host gene 7; EMT: Epithelial mesenchymal transition; TNM: Tumor-Lymph Node-Metastasis.</description><identifier>ISSN: 1538-4101</identifier><identifier>EISSN: 1551-4005</identifier><identifier>DOI: 10.1080/15384101.2019.1699753</identifier><identifier>PMID: 31814518</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Base Sequence ; Cell Line, Tumor ; Cell Movement - genetics ; Epithelial-Mesenchymal Transition - genetics ; Female ; gastric cancer ; Gene Expression Regulation, Neoplastic ; Humans ; lncRNA ; Male ; metastasis ; microRNA ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Middle Aged ; miR-43a ; Multivariate Analysis ; Neoplasm Invasiveness ; Prognosis ; Proportional Hazards Models ; Research Paper ; RNA, Long Noncoding - genetics ; RNA, Long Noncoding - metabolism ; Snail Family Transcription Factors - metabolism ; SNHG7 ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology</subject><ispartof>Cell cycle (Georgetown, Tex.), 2020-01, Vol.19 (1), p.142-152</ispartof><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019</rights><rights>2019 Informa UK Limited, trading as Taylor & Francis Group 2019 Informa UK Limited, trading as Taylor & Francis Group</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-13a7bb6edb1480479093707b64872b7a52b348d70b8e4f31e07fa0bb6432d2133</citedby><cites>FETCH-LOGICAL-c534t-13a7bb6edb1480479093707b64872b7a52b348d70b8e4f31e07fa0bb6432d2133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927713/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927713/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31814518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yangmei</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Zhang, Youwei</creatorcontrib><creatorcontrib>Cheng, Long</creatorcontrib><creatorcontrib>Zhou, Xichang</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><title>SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer</title><title>Cell cycle (Georgetown, Tex.)</title><addtitle>Cell Cycle</addtitle><description>Small nucleolar RNA host gene 7 (SNHG7) is a newly recognized oncogenic Long non-coding RNA (lncRNA) in most human cancers. In gastric cancer, SNHG7 has been suggested to enhance cell proliferation and suppressed apoptosis through down-regulating P15 and P16 expression, but the effect of SNHG7 on gastric cancer cell migration and invasion was still unknown. In our study, we aimed to estimate the relationship between SNHG7 expression and clinical and pathological characteristics, and explore the effect of SNHG7 on gastric cancer cell migration and invasion. In our study, the levels of SNHG7 expression in gastric cancer tissues and cell lines were severally higher than in normal adjacent tissues and gastric mucosal epithelial cells. Moreover, high SNHG7 expression was positively correlated with TNM stage, depth of invasion, lymph-node metastasis and distant metastasis in gastric cancer patients. Furthermore, the multivariate Cox proportional hazard analysis further showed high SNHG7 expression was an independent poor prognostic factor for overall survival in gastric cancer patients. The studies in vitro revealed that SNHG7 directly binds to miR-34a and negatively regulates miR-34a expression, and SNHG7 enhances gastric cancer cell migration and invasion through suppressing miR-34a-Snail-EMT axis. In conclusion, SNHG7 functions as oncogenic lncRNA in gastric cancer and may be a potential therapeutic target for gastric cancer patients.
Abbreviations: lncRNA: Long non-coding RNA; SNHG7: Small nucleolar RNA host gene 7; EMT: Epithelial mesenchymal transition; TNM: Tumor-Lymph Node-Metastasis.</description><subject>Base Sequence</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - genetics</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Female</subject><subject>gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>lncRNA</subject><subject>Male</subject><subject>metastasis</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Middle Aged</subject><subject>miR-43a</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Research Paper</subject><subject>RNA, Long Noncoding - genetics</subject><subject>RNA, Long Noncoding - metabolism</subject><subject>Snail Family Transcription Factors - metabolism</subject><subject>SNHG7</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><issn>1538-4101</issn><issn>1551-4005</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EoqXwE0A-csni8cfauSBQVVqkAhItZ2uSOFmjxC52Uui_x2G3FVw4zYzmeWdG8xLyEtgGmGFvQAkjgcGGM6g3sK1rrcQjcgxKQSUZU4_XXJhqhY7Is5y_M8aNruEpORJgQCowx8Rffb441xTb1o0u4ewyLdlIJz-UysdAMXTUh1vMazHvUlyGHU1uWMbSD0Mhv1ZCYnUV0I_V2adrir98LhI6YJ6Tb2mLoXXpOXnS45jdi0M8Id8-nF2fXlSXX84_nr6_rFol5FyBQN00W9c1IA2Tuma10Ew3W2k0bzQq3ghpOs0a42QvwDHdIysKKXjHQYgT8nY_92ZpJte1LswJR3uT_ITpzkb09t9O8Ds7xFu7rbnWfwa8PgxI8cfi8mwnn9enYHBxyZYLzstlAlhB1R5tU8w5uf5hDTC72mTvbbKrTfZgU9G9-vvGB9W9LwV4twd86GOa8GdMY2dnvBtj6lP5p88F_u-O3xuOobg</recordid><startdate>20200102</startdate><enddate>20200102</enddate><creator>Zhang, Yangmei</creator><creator>Yuan, Yuan</creator><creator>Zhang, Youwei</creator><creator>Cheng, Long</creator><creator>Zhou, Xichang</creator><creator>Chen, Kai</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20200102</creationdate><title>SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer</title><author>Zhang, Yangmei ; Yuan, Yuan ; Zhang, Youwei ; Cheng, Long ; Zhou, Xichang ; Chen, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-13a7bb6edb1480479093707b64872b7a52b348d70b8e4f31e07fa0bb6432d2133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Base Sequence</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - genetics</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Female</topic><topic>gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>lncRNA</topic><topic>Male</topic><topic>metastasis</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Middle Aged</topic><topic>miR-43a</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Research Paper</topic><topic>RNA, Long Noncoding - genetics</topic><topic>RNA, Long Noncoding - metabolism</topic><topic>Snail Family Transcription Factors - metabolism</topic><topic>SNHG7</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yangmei</creatorcontrib><creatorcontrib>Yuan, Yuan</creatorcontrib><creatorcontrib>Zhang, Youwei</creatorcontrib><creatorcontrib>Cheng, Long</creatorcontrib><creatorcontrib>Zhou, Xichang</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell cycle (Georgetown, Tex.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yangmei</au><au>Yuan, Yuan</au><au>Zhang, Youwei</au><au>Cheng, Long</au><au>Zhou, Xichang</au><au>Chen, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer</atitle><jtitle>Cell cycle (Georgetown, Tex.)</jtitle><addtitle>Cell Cycle</addtitle><date>2020-01-02</date><risdate>2020</risdate><volume>19</volume><issue>1</issue><spage>142</spage><epage>152</epage><pages>142-152</pages><issn>1538-4101</issn><eissn>1551-4005</eissn><abstract>Small nucleolar RNA host gene 7 (SNHG7) is a newly recognized oncogenic Long non-coding RNA (lncRNA) in most human cancers. In gastric cancer, SNHG7 has been suggested to enhance cell proliferation and suppressed apoptosis through down-regulating P15 and P16 expression, but the effect of SNHG7 on gastric cancer cell migration and invasion was still unknown. In our study, we aimed to estimate the relationship between SNHG7 expression and clinical and pathological characteristics, and explore the effect of SNHG7 on gastric cancer cell migration and invasion. In our study, the levels of SNHG7 expression in gastric cancer tissues and cell lines were severally higher than in normal adjacent tissues and gastric mucosal epithelial cells. Moreover, high SNHG7 expression was positively correlated with TNM stage, depth of invasion, lymph-node metastasis and distant metastasis in gastric cancer patients. Furthermore, the multivariate Cox proportional hazard analysis further showed high SNHG7 expression was an independent poor prognostic factor for overall survival in gastric cancer patients. The studies in vitro revealed that SNHG7 directly binds to miR-34a and negatively regulates miR-34a expression, and SNHG7 enhances gastric cancer cell migration and invasion through suppressing miR-34a-Snail-EMT axis. In conclusion, SNHG7 functions as oncogenic lncRNA in gastric cancer and may be a potential therapeutic target for gastric cancer patients.
Abbreviations: lncRNA: Long non-coding RNA; SNHG7: Small nucleolar RNA host gene 7; EMT: Epithelial mesenchymal transition; TNM: Tumor-Lymph Node-Metastasis.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>31814518</pmid><doi>10.1080/15384101.2019.1699753</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Base Sequence Cell Line, Tumor Cell Movement - genetics Epithelial-Mesenchymal Transition - genetics Female gastric cancer Gene Expression Regulation, Neoplastic Humans lncRNA Male metastasis microRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miR-43a Multivariate Analysis Neoplasm Invasiveness Prognosis Proportional Hazards Models Research Paper RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Snail Family Transcription Factors - metabolism SNHG7 Stomach Neoplasms - genetics Stomach Neoplasms - pathology |
| title | SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer |
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